compound 57 [PMID: 20121197] [Ligand Id: 6550] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL597557
  • coagulation factor IX/Coagulation factor IX in Human [ChEMBL: CHEMBL2016] [GtoPdb: 2364] [UniProtKB: P00740]
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  • coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
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  • plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
coagulation factor IX/Coagulation factor IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2016] [GtoPdb: 2364] [UniProtKB: P00740]
ChEMBL Inhibition of human recombinant factor 9a by amidolytic assay B 8.7 pKi 2 nM Ki J. Med. Chem. (2010) 53: 1473-1482 [PMID:20121197]
GtoPdb - - 8.7 pIC50 2 nM IC50 J Med Chem (2010) 53: 1473-82 [PMID:20121197]
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL Inhibition of factor 10a by amidolytic assay B 6.23 pKi 583 nM Ki J. Med. Chem. (2010) 53: 1473-1482 [PMID:20121197]
plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749]
ChEMBL Inhibition of uPA B 6.13 pKi 733 nM Ki J. Med. Chem. (2010) 53: 1473-1482 [PMID:20121197]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]