S 17092 [Ligand Id: 6565] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1086968
  • prolyl endopeptidase/Prolyl endopeptidase in Human [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147]
  • prolyl endopeptidase/Prolyl endopeptidase in Rat [ChEMBL: CHEMBL4035] [GtoPdb: 2395] [UniProtKB: O70196]
  • 8.89
1 CHEMBL1086968_lig_chart_1 Prolyl endopeptidase HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147]
GtoPdb - - 8.8 pKi 1.5 nM Ki J Med Chem (2010) 53: 3423-38 [PMID:20058865]
ChEMBL Inhibition of human POP B 8.82 pKi 1.5 nM Ki J. Med. Chem. (2010) 53: 3423-3438 [PMID:20058865]
ChEMBL Inhibition of human POP using Z-Gly-Pro-7-AMC substrate B 8.82 pKi 1.5 nM Ki J. Med. Chem. (2016) 59: 4221-4234 [PMID:26619267]
ChEMBL Inhibition of human recombinant POP expressed in sEscherichia coli B 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 4360-4363 [PMID:18606544]
prolyl endopeptidase/Prolyl endopeptidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4035] [GtoPdb: 2395] [UniProtKB: O70196]
ChEMBL inhibition of rat cortex POP B 8.89 pKi 1.3 nM Ki J. Med. Chem. (2010) 53: 3423-3438 [PMID:20058865]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]