efalizumab [Ligand Id: 6593] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201575 (ANTI-CD11A, Efalizumab, HU1124, HU-1124, Raptiva)
  • integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) in Human [GtoPdb: 2451] [UniProtKB: P20701]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) in Human [GtoPdb: 2451] [UniProtKB: P20701]
GtoPdb Binding of humanized MHM24 to human CD11a on Jurkat cells. - 11.4 pKd 0 nM Kd US6703018. Method of treatment using humanized anti-CD11a antibodies. (2004)

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]