donepezil [Ligand Id: 6599] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL502 (Aricept, D-797, Donaz, Donepezil, E-2020)
  • Acetylcholinesterase in Torpedo californica [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
  • Acetylcholinesterase in Bovine [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Mouse [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836]
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Rat [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136]
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  • carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141]
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  • beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
  • Butyrylcholinesterase in Equus caballus [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9]
  • butyrylcholinesterase/Butyrylcholinesterase in Mouse [ChEMBL: CHEMBL2528] [GtoPdb: 2471] [UniProtKB: Q03311]
  • Butyrylcholinesterase in Rat [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1]
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  • choline O-acetyltransferase/Choline acetylase in Rat [ChEMBL: CHEMBL3945] [GtoPdb: 2480] [UniProtKB: P32738]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
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  • phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
ChEMBL In vitro inhibition of Torpedo californica acetylcholinesterase. B 7.32 pIC50 48 nM IC50 J. Med. Chem. (1999) 42: 730-741 [PMID:10052979]
ChEMBL Inhibition of Torpedo californica AChE (type VI-S) using acetylthiocholine iodide as substrate assessed as 5-thio-2-nitrobenzoate anion formation preincubated for 15 mins followed by substrate addition B 7.64 pIC50 23 nM IC50 Eur. J. Med. Chem. (2015) 103: 361-369 [PMID:26363872]
ChEMBL Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in Torpedo californica B 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 575-580 [PMID:9871563]
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Non competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysis B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2013) 21: 5451-5460 [PMID:23810675]
ChEMBL Non-competitive inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measured at 12 secs interval for 5 mins by Ellman's method B 7.42 pKi 38 nM Ki Eur J Med Chem (2017) 130: 440-457 [PMID:28282613]
ChEMBL Inhibition of electric eel AChE assessed as inhibition constant using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition measured for 5 mins by Dixon plot analysis B 7.79 pKi 16.4 nM Ki Eur J Med Chem (2019) 174: 116-129 [PMID:31029943]
ChEMBL Inhibition of electric eel AChE pre-incubated for 3 mins before acetylthiocholine substrate addition by Lineweaver-Burk plot B 8.37 pKi 4.24 nM Ki Eur. J. Med. Chem. (2015) 97: 181-189 [PMID:25969170]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins by Ellman method B 4.58 pIC50 26100 nM IC50 Bioorg. Med. Chem. (2015) 23: 2445-2457 [PMID:25868744]
ChEMBL Inhibition of electric eel AChE by Ellman's method B 5.14 pIC50 7230 nM IC50 Bioorg. Med. Chem. (2014) 22: 6163-6173 [PMID:25257911]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins under dark condition by Ellman's method B 5.55 pIC50 2800 nM IC50 Bioorg Med Chem (2019) 27: 4030-4040 [PMID:31378596]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured for 5 mins by Ellmans method B 6.66 pIC50 219.7 nM IC50 Eur J Med Chem (2016) 124: 1026-1040 [PMID:27783974]
ChEMBL Inhibition of Electrophorus electricus AChE by Ellman's method B 6.92 pIC50 120 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5075-5077 [PMID:19643609]
ChEMBL Inhibition of electric eel AchE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method B 6.92 pIC50 120 nM IC50 Eur. J. Med. Chem. (2014) 76: 314-331 [PMID:24589487]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method B 6.96 pIC50 110 nM IC50 Eur. J. Med. Chem. (2015) 94: 348-366 [PMID:25778991]
ChEMBL Inhibition of Electrophorus electricus brain AChE by Ellman's method B 6.96 pIC50 110 nM IC50 Bioorg. Med. Chem. (2008) 16: 8011-8021 [PMID:18701305]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman method B 6.96 pIC50 110 nM IC50 Bioorg. Med. Chem. (2015) 23: 911-923 [PMID:25678013]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured for 45 mins by Ellmans microplate assay B 7 pIC50 100 nM IC50 Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576]
ChEMBL Inhibition of electric eel AChE using ACTI as substrate preincubated for 29 mins followed by substrate addition measured at 1 min intervals for 10 mins by Ellman's assay B 7.02 pIC50 96 nM IC50 J Med Chem (2016) 59: 7683-7689 [PMID:27405689]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measured after 20 mins by Ellman's method B 7.05 pIC50 90 nM IC50 Bioorg Med Chem (2018) 26: 3696-3706 [PMID:29886083]
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate after 30 mins by Ellman's method B 7.05 pIC50 90 nM IC50 MedChemComm (2012) 3: 1098-1103
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate by Ellman's method B 7.1 pIC50 80 nM IC50 Eur J Med Chem (2019) 179: 680-693 [PMID:31280020]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mins by UV spectrophotometric analysis B 7.17 pIC50 67 nM IC50 Eur J Med Chem (2017) 139: 612-632 [PMID:28841514]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and measured for 10 mins by Ellman's method B 7.21 pIC50 62 nM IC50 Eur J Med Chem (2021) 212: 113124-113124 [PMID:33395623]
ChEMBL Inhibition of electric eel AChE using thiocholine iodide as substrate by Ellman's method B 7.22 pIC50 59.9 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 5212-5216 [PMID:26454504]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by modified Ellman's method B 7.24 pIC50 57 nM IC50 Bioorg. Med. Chem. (2016) 24: 2352-2359 [PMID:27083471]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method B 7.29 pIC50 51 nM IC50 Eur J Med Chem (2016) 123: 282-297 [PMID:27484514]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 2 mins followed by substrate addition and measured after 2 mins by Ellman's method B 7.3 pIC50 50 nM IC50 Bioorg Med Chem (2018) 26: 3812-3824 [PMID:29960728]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 5 mins followed by substrate addition measured after 180 secs by Ellman's method B 7.3 pIC50 50 nM IC50 Eur J Med Chem (2018) 157: 161-176 [PMID:30096650]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 8 mins followed by substrate addition by Ellman's method B 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (2016) 26: 5573-5579 [PMID:27769620]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method B 7.3 pIC50 50 nM IC50 Eur J Med Chem (2017) 127: 671-690 [PMID:27823887]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method B 7.31 pIC50 49 nM IC50 Eur J Med Chem (2019) 175: 2-19 [PMID:31055149]
ChEMBL Inhibition of electric eel Ache using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by Ellman method B 7.31 pIC50 49 nM IC50 Bioorg Med Chem (2019) 27: 3156-3166 [PMID:31176571]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every minute for 10 mins by DTNB-reagent based Ellman's method B 7.31 pIC50 49 nM IC50 Eur J Med Chem (2020) 207: 112761-112761 [PMID:32942070]
ChEMBL Inhibition of electric eel AChE using DTNB as substrate incubated for 5 mins prior to substrate addition measured after 2 mins by Ellman's method B 7.31 pIC50 49 nM IC50 Bioorg. Med. Chem. (2015) 23: 6389-6403 [PMID:26337018]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's method B 7.32 pIC50 48 nM IC50 Bioorg. Med. Chem. (2015) 23: 1135-1148 [PMID:25624107]
ChEMBL In vitro inhibition of electric eel acetylcholinesterase B 7.32 pIC50 48 nM IC50 J. Med. Chem. (2001) 44: 2707-2718 [PMID:11495583]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition measured up to 180 secs by Ellman's method B 7.32 pIC50 47.4 nM IC50 Eur J Med Chem (2017) 139: 48-59 [PMID:28797883]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by spectroscopy based Ellman's method B 7.33 pIC50 47 nM IC50 Eur J Med Chem (2017) 136: 36-51 [PMID:28478343]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins by Ellman's method B 7.38 pIC50 42 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 5576-5582 [PMID:26514744]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 5 mins by Ellman's method B 7.39 pIC50 41.1 nM IC50 Eur J Med Chem (2020) 185: 111785-111785 [PMID:31669851]
ChEMBL Inhibition of electric eel acetylcholinesterase using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method B 7.39 pIC50 41 nM IC50 Bioorg. Med. Chem. (2014) 22: 1355-1361 [PMID:24461494]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior to substrate addition by Ellman's method B 7.39 pIC50 40.74 nM IC50 Bioorg. Med. Chem. (2013) 21: 5451-5460 [PMID:23810675]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 6 mins followed by substrate addition measured up to 180 sec by Ellman's method B 7.4 pIC50 40.2 nM IC50 Eur J Med Chem (2017) 133: 184-196 [PMID:28388521]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior to substrate addition by Ellman's method B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. (2013) 21: 5451-5460 [PMID:23810675]
ChEMBL Inhibition of electric eel AChE using acetylcholine iodide as substrate incubated for 20 mins prior to substrate addition by Ellman method B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 2984-2989 [PMID:23562059]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition measured up to 180 secs by spectrophotometric-based Ellman's method B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. (2016) 24: 1528-1539 [PMID:26917219]
ChEMBL Inhibition of electric eel ACHE preincubated for 6 mins followed by addition of acetylcholine iodide as substrate by Ellman's method B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. (2016) 24: 4324-4338 [PMID:27460699]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method B 7.4 pIC50 40 nM IC50 Bioorg Med Chem (2017) 25: 1471-1480 [PMID:28126439]
ChEMBL Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate after 10 mins measured for every mins by Ellman's method B 7.4 pIC50 40 nM IC50 Eur J Med Chem (2019) 163: 116-135 [PMID:30503937]
ChEMBL Inhibition of electric eel AChE by Ellman's method B 7.41 pIC50 39 nM IC50 Bioorg Med Chem Lett (2020) 30: 127477-127477 [PMID:32781220]
ChEMBL Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's method B 7.41 pIC50 39 nM IC50 Eur J Med Chem (2017) 125: 736-750 [PMID:27721157]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's method B 7.41 pIC50 39 nM IC50 Bioorg. Med. Chem. (2016) 24: 3829-3841 [PMID:27353888]
ChEMBL Inhibition of electric eel AChE preincubated for 15 mins by Ellman's method B 7.42 pIC50 38.2 nM IC50 Eur. J. Med. Chem. (2014) 87: 429-439 [PMID:25282266]
ChEMBL Inhibition of electric eel AChE preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 2 mins by Ellman's method B 7.42 pIC50 38 nM IC50 Eur J Med Chem (2016) 119: 260-277 [PMID:27227482]
ChEMBL Inhibition of electric eel AchE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition and measured after 2 mins by Ellman's method B 7.42 pIC50 38 nM IC50 Bioorg Med Chem (2016) 24: 2777-2788 [PMID:27157006]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method B 7.42 pIC50 38 nM IC50 J. Med. Chem. (2013) 56: 9089-9099 [PMID:24160297]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method B 7.42 pIC50 38 nM IC50 Eur. J. Med. Chem. (2016) 107: 219-232 [PMID:26588065]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric analysis B 7.43 pIC50 37 nM IC50 Bioorg Med Chem (2017) 25: 2946-2955 [PMID:28454848]
ChEMBL Inhibition of electric eel acetylcholinesterase preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 60 to 120 mins by Ellmans method B 7.46 pIC50 35 nM IC50 MedChemComm (2016) 7: 990-998
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate challenge measured after 15 mins by Ellman's method B 7.48 pIC50 33 nM IC50 Bioorg. Med. Chem. (2014) 22: 2496-2507 [PMID:24657052]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition and measured for 180 secs by Ellman's method B 7.49 pIC50 32 nM IC50 RSC Med Chem (2020) 11: 225-233 [PMID:33479629]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured for 6 mins by Ellman's method B 7.51 pIC50 31 nM IC50 Bioorg Med Chem (2017) 25: 3980-3988 [PMID:28587871]
ChEMBL Inhibition of electric eel AChE assessed as reduction in production of H202 using acetylcholine as substrate incubated for 15 mins followed by substrate addition by horse radish peroxidase/Amplex red reagent based fluorescence assay B 7.52 pIC50 30 nM IC50 Eur J Med Chem (2019) 177: 221-234 [PMID:31151057]
ChEMBL Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method B 7.52 pIC50 30 nM IC50 Eur. J. Med. Chem. (2014) 78: 167-177 [PMID:24681981]
ChEMBL Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method B 7.52 pIC50 30 nM IC50 Eur. J. Med. Chem. (2014) 78: 43-53 [PMID:24675179]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins by Ellman's method B 7.54 pIC50 29 nM IC50 Bioorg Med Chem Lett (2020) 30: 126900-126900 [PMID:31882295]
ChEMBL Inhibition of electric eel AChE preincubated for 15 mins followed by acetylthiocholine iodide substrate addition measured for 5 mins by Ellman's spectrophotometric method B 7.54 pIC50 28.7 nM IC50 Bioorg Med Chem Lett (2016) 26: 5387-5394 [PMID:27789142]
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method B 7.56 pIC50 27.4 nM IC50 Eur J Med Chem (2017) 126: 762-775 [PMID:27951485]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method B 7.57 pIC50 27 nM IC50 Eur J Med Chem (2017) 135: 307-323 [PMID:28458136]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method B 7.57 pIC50 27 nM IC50 Eur J Med Chem (2021) 216: 113310-113310 [PMID:33667847]
ChEMBL Inhibition of Electrophorus electricus AChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method B 7.58 pIC50 26.4 nM IC50 Bioorg Med Chem (2020) 28: 115400-115400 [PMID:32146060]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method B 7.59 pIC50 26 nM IC50 Eur J Med Chem (2018) 147: 48-65 [PMID:29421570]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method B 7.59 pIC50 26 nM IC50 Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367]
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measured at 12 secs interval for 5 mins by Ellman's method B 7.59 pIC50 26 nM IC50 Eur J Med Chem (2017) 130: 440-457 [PMID:28282613]
ChEMBL Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay B 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 4462-4466 [PMID:22633691]
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method B 7.6 pIC50 25 nM IC50 Bioorg Med Chem (2021) 35: 116074-116074 [PMID:33640707]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition measured every minute for 5 mins by Ellman's method B 7.6 pIC50 25 nM IC50 Eur J Med Chem (2019) 174: 116-129 [PMID:31029943]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method B 7.6 pIC50 25 nM IC50 Eur J Med Chem (2019) 181: 111598-111598 [PMID:31415981]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method B 7.62 pIC50 24 nM IC50 Eur J Med Chem (2019) 161: 292-309 [PMID:30366255]
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method B 7.64 pIC50 23 nM IC50 Bioorg Med Chem (2018) 26: 1885-1895 [PMID:29500132]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by Ellman's method B 7.64 pIC50 23 nM IC50 Bioorg Med Chem (2018) 26: 4952-4962 [PMID:30190181]
ChEMBL Inhibition of electric eel AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate addition and measured after 15 mins by Ellman's method B 7.64 pIC50 23 nM IC50 Bioorg Med Chem (2019) 27: 2914-2922 [PMID:31128990]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method B 7.64 pIC50 23 nM IC50 Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method B 7.65 pIC50 22.6 nM IC50 Bioorg Med Chem (2017) 25: 1997-2009 [PMID:28237559]
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method B 7.65 pIC50 22.6 nM IC50 Bioorg Med Chem (2017) 25: 714-726 [PMID:27923535]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured for 1 min by DTNB reagent-based spectrophotometric analysis B 7.66 pIC50 22 nM IC50 Eur J Med Chem (2019) 182: 111613-111613 [PMID:31437780]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by spectrophotometer analysis B 7.66 pIC50 22 nM IC50 Eur. J. Med. Chem. (2014) 82: 536-544 [PMID:24941128]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured for 20 mins at 1 min interval by Ellman's method B 7.68 pIC50 21.08 nM IC50 Eur J Med Chem (2018) 150: 87-101 [PMID:29524731]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method B 7.68 pIC50 21 nM IC50 Bioorg Med Chem (2018) 26: 6115-6127 [PMID:30470598]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured upto 5 mins by Ellman's method B 7.68 pIC50 21 nM IC50 Eur J Med Chem (2019) 177: 414-424 [PMID:31158754]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 5 mins by spectrophotometric Ellman's method B 7.68 pIC50 21 nM IC50 J Med Chem (2016) 59: 6791-6806 [PMID:27347731]
ChEMBL Inhibition of electric eel recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and measured after 20 mins by Ellman's method B 7.68 pIC50 21 nM IC50 Eur J Med Chem (2021) 223: 113663-113663 [PMID:34198150]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition measured for 10 mins by Ellman's method B 7.69 pIC50 20.3 nM IC50 MedChemComm (2012) 3: 627-634
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 5 mins by spectrophotometry based Ellman method B 7.7 pIC50 20 nM IC50 Bioorg Med Chem Lett (2017) 27: 1179-1185 [PMID:28189420]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine chloride by spectrophotometry B 7.7 pIC50 20 nM IC50 MedChemComm (2013) 4: 925-931
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition by Ellman's method B 7.7 pIC50 20 nM IC50 Eur J Med Chem (2018) 152: 600-614 [PMID:29763808]
ChEMBL Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide substrate by Ellman's method-based spectrophotometric analysis B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 2380-2382 [PMID:27017111]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide incubated for 15 mins as substrate by Ellman's method B 7.72 pIC50 19 nM IC50 Bioorg Med Chem Lett (2019) 29: 126625-126625 [PMID:31444085]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's method B 7.72 pIC50 19 nM IC50 Bioorg Med Chem (2017) 25: 3006-3017 [PMID:28487125]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine as substrate incubated for 15 mins by Ellman's method B 7.72 pIC50 19 nM IC50 Bioorg Med Chem Lett (2017) 27: 5046-5052 [PMID:29033233]
ChEMBL Inhibition of electric eel AChE by Ellman's method B 7.72 pIC50 19 nM IC50 Eur J Med Chem (2020) 192: 112180-112180 [PMID:32131034]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins by Ellman's method B 7.72 pIC50 19 nM IC50 Bioorg Med Chem Lett (2017) 27: 5053-5059 [PMID:29033232]
ChEMBL Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in electric eel B 7.77 pIC50 17 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 575-580 [PMID:9871563]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 1 to 3 mins time interval by Ellman's method B 7.79 pIC50 16.3 nM IC50 MedChemComm (2017) 8: 1459-1467 [PMID:30108857]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured for 2 mins by Ellman's method B 7.8 pIC50 16