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ChEMBL ligand: CHEMBL502 (Aricept, D-797, Donaz, Donepezil, E-2020) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
ChEMBL | In vitro inhibition of Torpedo californica acetylcholinesterase. | B | 7.32 | pIC50 | 48 | nM | IC50 | J. Med. Chem. (1999) 42: 730-741 [PMID:10052979] |
ChEMBL | Inhibition of Torpedo californica AChE (type VI-S) using acetylthiocholine iodide as substrate assessed as 5-thio-2-nitrobenzoate anion formation preincubated for 15 mins followed by substrate addition | B | 7.64 | pIC50 | 23 | nM | IC50 | Eur. J. Med. Chem. (2015) 103: 361-369 [PMID:26363872] |
ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in Torpedo californica | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg. Med. Chem. Lett. (1998) 8: 575-580 [PMID:9871563] |
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
ChEMBL | Non competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Lineweaver-Burk plot analysis | B | 7.25 | pKi | 56 | nM | Ki | Bioorg. Med. Chem. (2013) 21: 5451-5460 [PMID:23810675] |
ChEMBL | Non-competitive inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measured at 12 secs interval for 5 mins by Ellman's method | B | 7.42 | pKi | 38 | nM | Ki | Eur J Med Chem (2017) 130: 440-457 [PMID:28282613] |
ChEMBL | Inhibition of electric eel AChE assessed as inhibition constant using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition measured for 5 mins by Dixon plot analysis | B | 7.79 | pKi | 16.4 | nM | Ki | Eur J Med Chem (2019) 174: 116-129 [PMID:31029943] |
ChEMBL | Inhibition of electric eel AChE pre-incubated for 3 mins before acetylthiocholine substrate addition by Lineweaver-Burk plot | B | 8.37 | pKi | 4.24 | nM | Ki | Eur. J. Med. Chem. (2015) 97: 181-189 [PMID:25969170] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins by Ellman method | B | 4.58 | pIC50 | 26100 | nM | IC50 | Bioorg. Med. Chem. (2015) 23: 2445-2457 [PMID:25868744] |
ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.14 | pIC50 | 7230 | nM | IC50 | Bioorg. Med. Chem. (2014) 22: 6163-6173 [PMID:25257911] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins under dark condition by Ellman's method | B | 5.55 | pIC50 | 2800 | nM | IC50 | Bioorg Med Chem (2019) 27: 4030-4040 [PMID:31378596] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured for 5 mins by Ellmans method | B | 6.66 | pIC50 | 219.7 | nM | IC50 | Eur J Med Chem (2016) 124: 1026-1040 [PMID:27783974] |
ChEMBL | Inhibition of Electrophorus electricus AChE by Ellman's method | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg. Med. Chem. Lett. (2009) 19: 5075-5077 [PMID:19643609] |
ChEMBL | Inhibition of electric eel AchE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 6.92 | pIC50 | 120 | nM | IC50 | Eur. J. Med. Chem. (2014) 76: 314-331 [PMID:24589487] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 6.96 | pIC50 | 110 | nM | IC50 | Eur. J. Med. Chem. (2015) 94: 348-366 [PMID:25778991] |
ChEMBL | Inhibition of Electrophorus electricus brain AChE by Ellman's method | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg. Med. Chem. (2008) 16: 8011-8021 [PMID:18701305] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman method | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg. Med. Chem. (2015) 23: 911-923 [PMID:25678013] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured for 45 mins by Ellmans microplate assay | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576] |
ChEMBL | Inhibition of electric eel AChE using ACTI as substrate preincubated for 29 mins followed by substrate addition measured at 1 min intervals for 10 mins by Ellman's assay | B | 7.02 | pIC50 | 96 | nM | IC50 | J Med Chem (2016) 59: 7683-7689 [PMID:27405689] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measured after 20 mins by Ellman's method | B | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem (2018) 26: 3696-3706 [PMID:29886083] |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate after 30 mins by Ellman's method | B | 7.05 | pIC50 | 90 | nM | IC50 | MedChemComm (2012) 3: 1098-1103 |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 7.1 | pIC50 | 80 | nM | IC50 | Eur J Med Chem (2019) 179: 680-693 [PMID:31280020] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mins by UV spectrophotometric analysis | B | 7.17 | pIC50 | 67 | nM | IC50 | Eur J Med Chem (2017) 139: 612-632 [PMID:28841514] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and measured for 10 mins by Ellman's method | B | 7.21 | pIC50 | 62 | nM | IC50 | Eur J Med Chem (2021) 212: 113124-113124 [PMID:33395623] |
ChEMBL | Inhibition of electric eel AChE using thiocholine iodide as substrate by Ellman's method | B | 7.22 | pIC50 | 59.9 | nM | IC50 | Bioorg. Med. Chem. Lett. (2015) 25: 5212-5216 [PMID:26454504] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by modified Ellman's method | B | 7.24 | pIC50 | 57 | nM | IC50 | Bioorg. Med. Chem. (2016) 24: 2352-2359 [PMID:27083471] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method | B | 7.29 | pIC50 | 51 | nM | IC50 | Eur J Med Chem (2016) 123: 282-297 [PMID:27484514] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 2 mins followed by substrate addition and measured after 2 mins by Ellman's method | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem (2018) 26: 3812-3824 [PMID:29960728] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 5 mins followed by substrate addition measured after 180 secs by Ellman's method | B | 7.3 | pIC50 | 50 | nM | IC50 | Eur J Med Chem (2018) 157: 161-176 [PMID:30096650] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 8 mins followed by substrate addition by Ellman's method | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 5573-5579 [PMID:27769620] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 7.3 | pIC50 | 50 | nM | IC50 | Eur J Med Chem (2017) 127: 671-690 [PMID:27823887] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 7.31 | pIC50 | 49 | nM | IC50 | Eur J Med Chem (2019) 175: 2-19 [PMID:31055149] |
ChEMBL | Inhibition of electric eel Ache using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by Ellman method | B | 7.31 | pIC50 | 49 | nM | IC50 | Bioorg Med Chem (2019) 27: 3156-3166 [PMID:31176571] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every minute for 10 mins by DTNB-reagent based Ellman's method | B | 7.31 | pIC50 | 49 | nM | IC50 | Eur J Med Chem (2020) 207: 112761-112761 [PMID:32942070] |
ChEMBL | Inhibition of electric eel AChE using DTNB as substrate incubated for 5 mins prior to substrate addition measured after 2 mins by Ellman's method | B | 7.31 | pIC50 | 49 | nM | IC50 | Bioorg. Med. Chem. (2015) 23: 6389-6403 [PMID:26337018] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 5 mins by Ellman's method | B | 7.32 | pIC50 | 48 | nM | IC50 | Bioorg. Med. Chem. (2015) 23: 1135-1148 [PMID:25624107] |
ChEMBL | In vitro inhibition of electric eel acetylcholinesterase | B | 7.32 | pIC50 | 48 | nM | IC50 | J. Med. Chem. (2001) 44: 2707-2718 [PMID:11495583] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition measured up to 180 secs by Ellman's method | B | 7.32 | pIC50 | 47.4 | nM | IC50 | Eur J Med Chem (2017) 139: 48-59 [PMID:28797883] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by spectroscopy based Ellman's method | B | 7.33 | pIC50 | 47 | nM | IC50 | Eur J Med Chem (2017) 136: 36-51 [PMID:28478343] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins by Ellman's method | B | 7.38 | pIC50 | 42 | nM | IC50 | Bioorg. Med. Chem. Lett. (2015) 25: 5576-5582 [PMID:26514744] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 5 mins by Ellman's method | B | 7.39 | pIC50 | 41.1 | nM | IC50 | Eur J Med Chem (2020) 185: 111785-111785 [PMID:31669851] |
ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 7.39 | pIC50 | 41 | nM | IC50 | Bioorg. Med. Chem. (2014) 22: 1355-1361 [PMID:24461494] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior to substrate addition by Ellman's method | B | 7.39 | pIC50 | 40.74 | nM | IC50 | Bioorg. Med. Chem. (2013) 21: 5451-5460 [PMID:23810675] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 6 mins followed by substrate addition measured up to 180 sec by Ellman's method | B | 7.4 | pIC50 | 40.2 | nM | IC50 | Eur J Med Chem (2017) 133: 184-196 [PMID:28388521] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior to substrate addition by Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg. Med. Chem. (2013) 21: 5451-5460 [PMID:23810675] |
ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as substrate incubated for 20 mins prior to substrate addition by Ellman method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 2984-2989 [PMID:23562059] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition measured up to 180 secs by spectrophotometric-based Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg. Med. Chem. (2016) 24: 1528-1539 [PMID:26917219] |
ChEMBL | Inhibition of electric eel ACHE preincubated for 6 mins followed by addition of acetylcholine iodide as substrate by Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg. Med. Chem. (2016) 24: 4324-4338 [PMID:27460699] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2017) 25: 1471-1480 [PMID:28126439] |
ChEMBL | Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate after 10 mins measured for every mins by Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Eur J Med Chem (2019) 163: 116-135 [PMID:30503937] |
ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 7.41 | pIC50 | 39 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127477-127477 [PMID:32781220] |
ChEMBL | Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's method | B | 7.41 | pIC50 | 39 | nM | IC50 | Eur J Med Chem (2017) 125: 736-750 [PMID:27721157] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's method | B | 7.41 | pIC50 | 39 | nM | IC50 | Bioorg. Med. Chem. (2016) 24: 3829-3841 [PMID:27353888] |
ChEMBL | Inhibition of electric eel AChE preincubated for 15 mins by Ellman's method | B | 7.42 | pIC50 | 38.2 | nM | IC50 | Eur. J. Med. Chem. (2014) 87: 429-439 [PMID:25282266] |
ChEMBL | Inhibition of electric eel AChE preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 2 mins by Ellman's method | B | 7.42 | pIC50 | 38 | nM | IC50 | Eur J Med Chem (2016) 119: 260-277 [PMID:27227482] |
ChEMBL | Inhibition of electric eel AchE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition and measured after 2 mins by Ellman's method | B | 7.42 | pIC50 | 38 | nM | IC50 | Bioorg Med Chem (2016) 24: 2777-2788 [PMID:27157006] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method | B | 7.42 | pIC50 | 38 | nM | IC50 | J. Med. Chem. (2013) 56: 9089-9099 [PMID:24160297] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 7.42 | pIC50 | 38 | nM | IC50 | Eur. J. Med. Chem. (2016) 107: 219-232 [PMID:26588065] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric analysis | B | 7.43 | pIC50 | 37 | nM | IC50 | Bioorg Med Chem (2017) 25: 2946-2955 [PMID:28454848] |
ChEMBL | Inhibition of electric eel acetylcholinesterase preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 60 to 120 mins by Ellmans method | B | 7.46 | pIC50 | 35 | nM | IC50 | MedChemComm (2016) 7: 990-998 |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate challenge measured after 15 mins by Ellman's method | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg. Med. Chem. (2014) 22: 2496-2507 [PMID:24657052] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition and measured for 180 secs by Ellman's method | B | 7.49 | pIC50 | 32 | nM | IC50 | RSC Med Chem (2020) 11: 225-233 [PMID:33479629] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured for 6 mins by Ellman's method | B | 7.51 | pIC50 | 31 | nM | IC50 | Bioorg Med Chem (2017) 25: 3980-3988 [PMID:28587871] |
ChEMBL | Inhibition of electric eel AChE assessed as reduction in production of H202 using acetylcholine as substrate incubated for 15 mins followed by substrate addition by horse radish peroxidase/Amplex red reagent based fluorescence assay | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2019) 177: 221-234 [PMID:31151057] |
ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur. J. Med. Chem. (2014) 78: 167-177 [PMID:24681981] |
ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur. J. Med. Chem. (2014) 78: 43-53 [PMID:24675179] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins by Ellman's method | B | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126900-126900 [PMID:31882295] |
ChEMBL | Inhibition of electric eel AChE preincubated for 15 mins followed by acetylthiocholine iodide substrate addition measured for 5 mins by Ellman's spectrophotometric method | B | 7.54 | pIC50 | 28.7 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 5387-5394 [PMID:27789142] |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 7.56 | pIC50 | 27.4 | nM | IC50 | Eur J Med Chem (2017) 126: 762-775 [PMID:27951485] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 7.57 | pIC50 | 27 | nM | IC50 | Eur J Med Chem (2017) 135: 307-323 [PMID:28458136] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 7.57 | pIC50 | 27 | nM | IC50 | Eur J Med Chem (2021) 216: 113310-113310 [PMID:33667847] |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method | B | 7.58 | pIC50 | 26.4 | nM | IC50 | Bioorg Med Chem (2020) 28: 115400-115400 [PMID:32146060] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | B | 7.59 | pIC50 | 26 | nM | IC50 | Eur J Med Chem (2018) 147: 48-65 [PMID:29421570] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method | B | 7.59 | pIC50 | 26 | nM | IC50 | Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367] |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measured at 12 secs interval for 5 mins by Ellman's method | B | 7.59 | pIC50 | 26 | nM | IC50 | Eur J Med Chem (2017) 130: 440-457 [PMID:28282613] |
ChEMBL | Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay | B | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg. Med. Chem. Lett. (2012) 22: 4462-4466 [PMID:22633691] |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem (2021) 35: 116074-116074 [PMID:33640707] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition measured every minute for 5 mins by Ellman's method | B | 7.6 | pIC50 | 25 | nM | IC50 | Eur J Med Chem (2019) 174: 116-129 [PMID:31029943] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method | B | 7.6 | pIC50 | 25 | nM | IC50 | Eur J Med Chem (2019) 181: 111598-111598 [PMID:31415981] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 7.62 | pIC50 | 24 | nM | IC50 | Eur J Med Chem (2019) 161: 292-309 [PMID:30366255] |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem (2018) 26: 1885-1895 [PMID:29500132] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by Ellman's method | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem (2018) 26: 4952-4962 [PMID:30190181] |
ChEMBL | Inhibition of electric eel AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate addition and measured after 15 mins by Ellman's method | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem (2019) 27: 2914-2922 [PMID:31128990] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 7.65 | pIC50 | 22.6 | nM | IC50 | Bioorg Med Chem (2017) 25: 1997-2009 [PMID:28237559] |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 7.65 | pIC50 | 22.6 | nM | IC50 | Bioorg Med Chem (2017) 25: 714-726 [PMID:27923535] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured for 1 min by DTNB reagent-based spectrophotometric analysis | B | 7.66 | pIC50 | 22 | nM | IC50 | Eur J Med Chem (2019) 182: 111613-111613 [PMID:31437780] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by spectrophotometer analysis | B | 7.66 | pIC50 | 22 | nM | IC50 | Eur. J. Med. Chem. (2014) 82: 536-544 [PMID:24941128] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured for 20 mins at 1 min interval by Ellman's method | B | 7.68 | pIC50 | 21.08 | nM | IC50 | Eur J Med Chem (2018) 150: 87-101 [PMID:29524731] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem (2018) 26: 6115-6127 [PMID:30470598] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured upto 5 mins by Ellman's method | B | 7.68 | pIC50 | 21 | nM | IC50 | Eur J Med Chem (2019) 177: 414-424 [PMID:31158754] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 5 mins by spectrophotometric Ellman's method | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2016) 59: 6791-6806 [PMID:27347731] |
ChEMBL | Inhibition of electric eel recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and measured after 20 mins by Ellman's method | B | 7.68 | pIC50 | 21 | nM | IC50 | Eur J Med Chem (2021) 223: 113663-113663 [PMID:34198150] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition measured for 10 mins by Ellman's method | B | 7.69 | pIC50 | 20.3 | nM | IC50 | MedChemComm (2012) 3: 627-634 |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 5 mins by spectrophotometry based Ellman method | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1179-1185 [PMID:28189420] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride by spectrophotometry | B | 7.7 | pIC50 | 20 | nM | IC50 | MedChemComm (2013) 4: 925-931 |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition by Ellman's method | B | 7.7 | pIC50 | 20 | nM | IC50 | Eur J Med Chem (2018) 152: 600-614 [PMID:29763808] |
ChEMBL | Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide substrate by Ellman's method-based spectrophotometric analysis | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg. Med. Chem. Lett. (2016) 26: 2380-2382 [PMID:27017111] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide incubated for 15 mins as substrate by Ellman's method | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126625-126625 [PMID:31444085] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's method | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem (2017) 25: 3006-3017 [PMID:28487125] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine as substrate incubated for 15 mins by Ellman's method | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5046-5052 [PMID:29033233] |
ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 7.72 | pIC50 | 19 | nM | IC50 | Eur J Med Chem (2020) 192: 112180-112180 [PMID:32131034] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins by Ellman's method | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 5053-5059 [PMID:29033232] |
ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in electric eel | B | 7.77 | pIC50 | 17 | nM | IC50 | Bioorg. Med. Chem. Lett. (1998) 8: 575-580 [PMID:9871563] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 1 to 3 mins time interval by Ellman's method | B | 7.79 | pIC50 | 16.3 | nM | IC50 | MedChemComm (2017) 8: 1459-1467 [PMID:30108857] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured for 2 mins by Ellman's method | B | 7.8 | pIC50 | 16 |