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ChEMBL ligand: CHEMBL574003 (HQL-79) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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H-PGDS/Hematopoietic prostaglandin D synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5879] [GtoPdb: 1381] [UniProtKB: O60760] | ||||||||
ChEMBL | Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uM | B | 4.13 | pIC50 | 73900 | nM | IC50 | J. Med. Chem. (2010) 53: 5536-5548 [PMID:20684598] |
ChEMBL | Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay | B | 5.42 | pIC50 | 3800 | nM | IC50 | J. Med. Chem. (2010) 53: 5536-5548 [PMID:20684598] |
GtoPdb | - | - | 5.5 | pIC50 | - | - | - | J Biol Chem (2006) 281: 15277-86 [PMID:16547010] |
ChEMBL | Inhibition of human H-PGDS expressed in Escherichia coli BL21 assessed as rate of glutathione-chloro-dinitro benzene conjugation | B | 5.74 | pIC50 | 1800 | nM | IC50 | Eur. J. Med. Chem. (2010) 45: 447-454 [PMID:19939518] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]