HQL-79 [Ligand Id: 6662] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL574003 (HQL-79)
  • H-PGDS/Hematopoietic prostaglandin D synthase in Human [ChEMBL: CHEMBL5879] [GtoPdb: 1381] [UniProtKB: O60760]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
H-PGDS/Hematopoietic prostaglandin D synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5879] [GtoPdb: 1381] [UniProtKB: O60760]
ChEMBL Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uM B 4.13 pIC50 73900 nM IC50 J. Med. Chem. (2010) 53: 5536-5548 [PMID:20684598]
ChEMBL Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay B 5.42 pIC50 3800 nM IC50 J. Med. Chem. (2010) 53: 5536-5548 [PMID:20684598]
GtoPdb - - 5.5 pIC50 - - - J Biol Chem (2006) 281: 15277-86 [PMID:16547010]
ChEMBL Inhibition of human H-PGDS expressed in Escherichia coli BL21 assessed as rate of glutathione-chloro-dinitro benzene conjugation B 5.74 pIC50 1800 nM IC50 Eur. J. Med. Chem. (2010) 45: 447-454 [PMID:19939518]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]