myriocin [Ligand Id: 6664] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL55076 (Myriocin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| serine palmitoyltransferase long chain base subunit 1/Serine palmitoyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250343] [GtoPdb: 2509] [UniProtKB: O15269] | ||||||||
| ChEMBL | Inhibition of SPT1 in human MCF7 cells assessed as suppression of 14C-serine incorporation into ceramide incubated for 2 hrs in presence of 4-HPR | B | 7.31 | pEC50 | 49.5 | nM | EC50 | J Med Chem (2016) 59: 5904-5910 [PMID:27213958] |
| serine palmitoyltransferase long chain base subunit 1 in Mouse [GtoPdb: 2509] [UniProtKB: O35704] | ||||||||
| GtoPdb | - | - | 9.55 | pKi | 0.28 | nM | Ki | Biochem Biophys Res Commun (1995) 211: 396-403 [PMID:7794249] |
| serine palmitoyltransferase long chain base subunit 2/Serine palmitoyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250344] [GtoPdb: 2510] [UniProtKB: O15270] | ||||||||
| ChEMBL | Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substrate addition measured after 15 mins by mass spectrometric analysis | B | 9.89 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem (2018) 26: 2452-2465 [PMID:29669694] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
