CCG-203971 [Ligand Id: 6763] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2398678 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Transforming protein RhoA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6052] [UniProtKB: P61586] | ||||||||
| ChEMBL | Inhibition of RhoC-mediated pathway in human PC3 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay | B | 5.19 | pIC50 | 6400 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3826-3832 [PMID:23707258] |
| ChEMBL | Inhibition of RhoC-mediated pathway in human SK-Mel-147 cells assessed as inhibition of SRE-regulated gene transcription by luciferase reporter gene assay | B | 5.28 | pIC50 | 5300 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3826-3832 [PMID:23707258] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
