brinzolamide [Ligand Id: 6797] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL220491 (Brinzolamide, Azopt, AL-4862)
  • AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
  • This target only has 1 pki data point
1 CHEMBL220491_lig_chart_1 AGAP002992-PA Anopheles gambiae
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  • Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
2 CHEMBL220491_lig_chart_2 Alpha carbonic anhydrase Stylophora pistillata
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  • Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
  • This target only has 1 pki data point
3 CHEMBL220491_lig_chart_3 Astrosclerin-3 Astrosclera willeyana
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  • Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
  • This target only has 1 pki data point
4 CHEMBL220491_lig_chart_4 Carbonate dehydratase Sulfurihydrogenibium sp. (strain YO3AOP1)
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  • Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
  • Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
  • Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
  • Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
  • Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
5 CHEMBL220491_lig_chart_5 Carbonic anhydrase Mycobacterium tuberculosisStylophora pistillataCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Candida glabrata CBS 138Saccharomyces cerevisiae S288c
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  • Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
6 CHEMBL220491_lig_chart_6 Carbonic anhydrase 1 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
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  • Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
  • This target only has 1 pki data point
7 CHEMBL220491_lig_chart_7 Carbonic anhydrase 15 Mouse
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  • Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
  • This target only has 1 pki data point
8 CHEMBL220491_lig_chart_8 Carbonic anhydrase 2 Cryptococcus neoformans var. grubii
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  • Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
  • This target only has 1 pki data point
9 CHEMBL220491_lig_chart_9 Carbonic anhydrase, alpha family Thiomicrospira crunogena (strain XCL-2)
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
10 CHEMBL220491_lig_chart_10 Carbonic anhydrase I Human
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
11 CHEMBL220491_lig_chart_11 Carbonic anhydrase II Human
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
  • Carbonic anhydrase IV in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
12 CHEMBL220491_lig_chart_12 Carbonic anhydrase IV HumanBovine
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
13 CHEMBL220491_lig_chart_13 Carbonic anhydrase IX Human
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
14 CHEMBL220491_lig_chart_14 Carbonic anhydrase VA Human
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15 CHEMBL220491_lig_chart_15 Carbonic anhydrase VB Human
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16 CHEMBL220491_lig_chart_16 Carbonic anhydrase VI Human
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
17 CHEMBL220491_lig_chart_17 Carbonic anhydrase VII Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
18 CHEMBL220491_lig_chart_18 Carbonic anhydrase XII Human
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
19 CHEMBL220491_lig_chart_19 Carbonic anhydrase XIII HumanMouse
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
20 CHEMBL220491_lig_chart_20 Carbonic anhydrase XIV Human
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  • Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
  • This target only has 1 pki data point
21 CHEMBL220491_lig_chart_21 Delta carbonic anhydrase Thalassiosira weissflogii
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  • PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
  • This target only has 1 pki data point
22 CHEMBL220491_lig_chart_22 PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Mycobacterium tuberculosis
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  • Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
23 CHEMBL220491_lig_chart_23 Uncharacterized protein Rv1284/MT1322 Mycobacterium tuberculosis
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 7.5 pKi 31.4 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay B 7.32 pKi 48.2 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay B 7.32 pKi 48.2 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 6.56 pKi 278 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay B 7.91 pKi 12.3 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay B 6.9 pKi 127 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay B 6.77 pKi 169 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay B 5.96 pKi 1095 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 5.96 pKi 1095 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 5.36 pKi 4350 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 2647-2652 [PMID:23511020]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay B 6.94 pKi 114 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL Inhibition of Helicobacter pylori recombinant CA B 6.61 pKi 246 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay B 6.68 pKi 210 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay B 7.21 pKi 61 nM Ki J. Med. Chem. (2009) 52: 646-654 [PMID:19193158]
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
ChEMBL Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 7.06 pKi 87 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay B 8.38 pKi 4.2 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay B 4.35 pKi 45000 nM Ki Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2015) 23: 526-531 [PMID:25533402]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
ChEMBL Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis B 4.35 pKi 45000 nM Ki Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 4.35 pKi 45000 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL Inhibition of human recombinant CA1 B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method B 4.35 pKi 45000 nM Ki J. Med. Chem. (2007) 50: 381-388 [PMID:17228881]
ChEMBL Inhibition of human carbonic anhydrase 1 B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method B 4.35 pKi 45000 nM Ki J. Med. Chem. (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay B 4.35 pKi 45000 nM Ki J. Med. Chem. (2009) 52: 646-654 [PMID:19193158]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay B 4.35 pKi 45000 nM Ki J. Med. Chem. (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
ChEMBL Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay B 4.35 pKi 45000 nM Ki J. Med. Chem. (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2014) 22: 1586-1595 [PMID:24513184]
GtoPdb - - 4.35 pKi 45000 nM Ki Bioorg. Med. Chem. (2013) 21: 5973-82 [PMID:23965175]
ChEMBL Inhibition of human cloned CA1 by CO2 hydration method B 6.35 pKi 450 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay B 6.35 pKi 450 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL Inhibition of human cloned CA1 by CO2 hydration method B 6.35 pKi 450 nM Ki J. Med. Chem. (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL Inhibition of human cloned CA1 by CO2 hydration method B 7.82 pKi 15 nM Ki J. Med. Chem. (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL Inhibition of human recombinant isozyme CA1 by CO2 hydration method B 7.82 pKi 15 nM Ki J. Med. Chem. (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL Inhibitory activity against human recombinant carbonic anhydrase I (CA1) B 8.49 pKi 3.2 nM Ki J. Med. Chem. (1999) 42: 3690-3700 [PMID:10479300]
ChEMBL Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II) by esterase method B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2003) 13: 837-840 [PMID:12617903]
ChEMBL Compound was evaluated for binding affinity against human carbonic anhydrase II (hCA -II) B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1787-1791 [PMID:11425561]
ChEMBL Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method. B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL Inhibitory activity against Human Carbonic anhydrase II B 8.52 pKi 3 nM Ki J. Med. Chem. (2002) 45: 1466-1476 [PMID:11906288]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Binding affinity against Carbonic anhydrase II B 9.89 pKd -9.89 - Log Kd J. Med. Chem. (2002) 45: 2770-2780 [PMID:12061879]
ChEMBL Binding affinity to human carbonic anhydrase 2 incubated for 1 hr using labeled BODIPY558/568-acetazolamide as tracer by fluorescence polarization tight binding assay B 10.05 pKd 0.09 nM Kd J. Med. Chem. (2015) 58: 2821-2833 [PMID:25728019]
ChEMBL Inhibitory activity against human recombinant carbonic anhydrase II (CA2) B 7.34 pKi 45.3 nM Ki J. Med. Chem. (1999) 42: 3690-3700 [PMID:10479300]
ChEMBL Compound was evaluated for binding affinity against bovine carbonic anhydrase IV (bCA IV) B 7.35 pKi 45 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 1787-1791 [PMID:11425561]
ChEMBL Inhibition of human recombinant isozyme CA2 by CO2 hydration method B 8.05 pKi 9 nM Ki J. Med. Chem. (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL Inhibition of human cloned CA2 by CO2 hydration method B 8.05 pKi 9 nM Ki J. Med. Chem. (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL Inhibition of human carbonic anhydrase2 preincubated for 15 mins by stopped-flow CO2 hydration assay B 8.49 pKi 3.2 nM Ki Bioorg. Med. Chem. (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL Inhibitory activity against human recombinant carbonic anhydrase II B 8.49 pKi 3.2 nM Ki J. Med. Chem. (1999) 42: 2641-2650 [PMID:10411484]
ChEMBL Inhibitory activity against human carbonic anhydrase II B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL Inhibitory activity against cytosolic human carbonic anhydrase II B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 579-584 [PMID:15664816]
ChEMBL Ki value against human carbonic anhydrase II B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 971-976 [PMID:15686895]
ChEMBL Ki value against human carbonic anhydrase II (hCA II) B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 963-969 [PMID:15686894]
ChEMBL Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21 B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL Inhibitory constant against human Carbonic anhydrase II B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL Inhibitory activity against human recombinant cytosolic CA2 B 8.52 pKi 3 nM Ki J. Med. Chem. (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay B 8.52 pKi 3 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL Inhibition of human recombinant CA2 B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL Inhibition of human cloned CA2 by stopped-flow CO2 hydration method B 8.52 pKi 3 nM Ki J. Med. Chem. (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method B 8.52 pKi 3 nM Ki J. Med. Chem. (2007) 50: 381-388 [PMID:17228881]
ChEMBL Inhibition of human cloned CA2 by CO2 hydration method B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL Inhibition of human carbonic anhydrase 2 B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL Inhibition of human cloned CA2 by CO2 hydration method B 8.52 pKi 3 nM Ki J. Med. Chem. (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay B 8.52 pKi 3 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay B 8.52 pKi