methazolamide [Ligand Id: 6828] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1335656
  • carbonic anhydrase 1 in Human [GtoPdb: 2597] [UniProtKB: P00915]
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  • carbonic anhydrase 14 in Human [GtoPdb: 2598] [UniProtKB: Q9ULX7]
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  • carbonic anhydrase 4 in Human [GtoPdb: 2599] [UniProtKB: P22748]
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  • carbonic anhydrase 12 in Human [GtoPdb: 2747] [UniProtKB: O43570]
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  • carbonic anhydrase 7 in Human [GtoPdb: 2749] [UniProtKB: P43166]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
carbonic anhydrase 1 in Human [GtoPdb: 2597] [UniProtKB: P00915]
GtoPdb - - 7.48 pKi 33 nM Ki Bioorg Med Chem Lett (2005) 15: 3828-33 [PMID:16039848];
Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]
carbonic anhydrase 14 in Human [GtoPdb: 2598] [UniProtKB: Q9ULX7]
GtoPdb - - 7.57 pKi 27 nM Ki Bioorg Med Chem Lett (2005) 15: 3828-33 [PMID:16039848]
carbonic anhydrase 4 in Human [GtoPdb: 2599] [UniProtKB: P22748]
GtoPdb - - 7.62 pKi 24 nM Ki Bioorg Med Chem Lett (2005) 15: 3828-33 [PMID:16039848]
carbonic anhydrase 12 in Human [GtoPdb: 2747] [UniProtKB: O43570]
GtoPdb - - 8.47 pKi 3.4 nM Ki Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]
carbonic anhydrase 7 in Human [GtoPdb: 2749] [UniProtKB: P43166]
GtoPdb - - 8.68 pKi 2.1 nM Ki Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]