nateglinide [Ligand Id: 6833] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL783 (Starlix, DJN-608, Nateglinide, AY-4166, SDZ DJN 608, A-4166, SDZ-DJN-608, Starsis)
  • Peptide transporter 2/Oligopeptide transporter, kidney isoform in Rat [ChEMBL: CHEMBL3325] [GtoPdb: 985] [UniProtKB: Q63424]
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Peptide transporter 2/Oligopeptide transporter, kidney isoform in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3325] [GtoPdb: 985] [UniProtKB: Q63424]
ChEMBL TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT2-expressing LLC-PK1 cells F 4.15 pIC50 70000 nM IC50 Eur. J. Pharmacol. (2000) 392: 11-17 [PMID:10748266]
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
ChEMBL Inhibition of rat Oat1 expressed in Xenopus oocytes B 5.04 pKi 9200 nM Ki Bioorg. Med. Chem. (2011) 19: 3320-3340 [PMID:21571536]
ChEMBL TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes F 5.04 pKi 9200 nM Ki Eur. J. Pharmacol. (2000) 398: 193-197 [PMID:10854830]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]