pemetrexed [Ligand Id: 6837] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1201258
  • dihydrofolate reductase in Human [GtoPdb: 2603] [UniProtKB: P00374]
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  • phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase in Mouse [GtoPdb: 2612] [UniProtKB: Q64737]
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  • thymidylate synthetase in Human [GtoPdb: 2642] [UniProtKB: P04818]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dihydrofolate reductase in Human [GtoPdb: 2603] [UniProtKB: P00374]
GtoPdb - - 8.15 pKi 7 nM Ki J Med Chem (2005) 48: 5329-36 [PMID:16078850];
Adv Enzyme Regul (1998) 38: 135-52 [PMID:9762351]
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase in Mouse [GtoPdb: 2612] [UniProtKB: Q64737]
GtoPdb - - 5.03 pKi 9300 nM Ki Adv Enzyme Regul (1998) 38: 135-52 [PMID:9762351]
thymidylate synthetase in Human [GtoPdb: 2642] [UniProtKB: P04818]
GtoPdb - - 6.96 pKi 109 nM Ki Adv Enzyme Regul (1998) 38: 135-52 [PMID:9762351]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]