ChEMBL ligand: CHEMBL1201258
dihydrofolate reductase in Human [GtoPdb: 2603] [UniProtKB: P00374] There should be some charts here, you may need to enable JavaScript!
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase in Mouse [GtoPdb: 2612] [UniProtKB: Q64737] There should be some charts here, you may need to enable JavaScript!
thymidylate synthetase in Human [GtoPdb: 2642] [UniProtKB: P04818] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
dihydrofolate reductase in Human [GtoPdb: 2603] [UniProtKB: P00374]
GtoPdb	-	-	8.15	pKi	7	nM	Ki	J Med Chem (2005) 48: 5329-36 [PMID:16078850]; Adv Enzyme Regul (1998) 38: 135-52 [PMID:9762351]
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase in Mouse [GtoPdb: 2612] [UniProtKB: Q64737]
GtoPdb	-	-	5.03	pKi	9300	nM	Ki	Adv Enzyme Regul (1998) 38: 135-52 [PMID:9762351]
thymidylate synthetase in Human [GtoPdb: 2642] [UniProtKB: P04818]
GtoPdb	-	-	6.96	pKi	109	nM	Ki	Adv Enzyme Regul (1998) 38: 135-52 [PMID:9762351]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]