azilsartan [Ligand Id: 6901] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL57242 (Azilsartan, TAK-536)
  • Angiotensin II type 1a (AT-1a) receptor in Bovine [ChEMBL: CHEMBL3374] [UniProtKB: P25104]
  • This target only has 0 pki data point
  • 0
1 CHEMBL57242_lig_chart_1 Angiotensin II type 1a (AT-1a) receptor Bovine
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  • AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
  • This target only has 0 pki data point
  • 0
2 CHEMBL57242_lig_chart_2 AT1 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin II type 1a (AT-1a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3374] [UniProtKB: P25104]
ChEMBL Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M B 6.38 pIC50 420 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 1903-1908
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
GtoPdb - - 8.13 pIC50 7.4 nM IC50 Clin Ther (2014) 36: 711-21 [PMID:24742498];
Hypertens Res (2014) 37: 852-7 [PMID:24739538]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]