trichostatin A [Ligand Id: 7005] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL99 (GNF-Pf-1011, ANTIBIOTIC A-300, Trichostatin(s), A-300-I, Trichostatin)
There should be some charts here, you may need to enable JavaScript!
  • Histone deacetylase in Plasmodium falciparum [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
  • histone deacetylase 1/Histone deacetylase 1 in Mouse [ChEMBL: CHEMBL4001] [GtoPdb: 2658] [UniProtKB: O09106]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 11/Histone deacetylase 11 in Human [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379Q9Y618]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 5/Histone deacetylase 5 in Human [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6]
  • histone deacetylase 5/Histone deacetylase 5 in Mouse [ChEMBL: CHEMBL2768] [GtoPdb: 2660] [UniProtKB: Q9Z2V6]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
  • histone deacetylase 6/Histone deacetylase 6 in Mouse [ChEMBL: CHEMBL2878] [GtoPdb: 2618] [UniProtKB: Q9Z2V5]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 7/Histone deacetylase 7 in Human [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4]
There should be some charts here, you may need to enable JavaScript!
  • Histone deacetylase 8 in Schistosoma mansoni [ChEMBL: CHEMBL3797017] [UniProtKB: A5H660]
  • histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
  • histone deacetylase 8/Histone deacetylase 8 in Mouse [ChEMBL: CHEMBL2347] [GtoPdb: 2619] [UniProtKB: Q8VH37]
There should be some charts here, you may need to enable JavaScript!
  • histone deacetylase 9/Histone deacetylase 9 in Human [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Histone deacetylase-like amidohydrolase in Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) [ChEMBL: CHEMBL6017] [UniProtKB: Q70I53]
There should be some charts here, you may need to enable JavaScript!
  • Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
There should be some charts here, you may need to enable JavaScript!
  • sirtuin 6/NAD-dependent protein deacetylase sirtuin-6 in Human [ChEMBL: CHEMBL2163182] [GtoPdb: 2712] [UniProtKB: Q8N6T7]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [UniProtKB: P13726]
ChEMBL Inhibition of LPS-induced tissue factor activity in human PBMC preincubated for 4 hrs assessed after 5 hrs of LPS challenge by one stage clotting assay B 7.3 pIC50 50 nM IC50 J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
ChEMBL Inhibition of IL-1-beta-induced tissue factor activity in human PBMC preincubated for 4 hrs assessed after 5 hrs of IL1-beta challenge by one stage clotting assay B 7.3 pIC50 50 nM IC50 J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
ChEMBL Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay B 7.52 pIC50 30 nM IC50 J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
ChEMBL Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay B 7.7 pIC50 20 nM IC50 J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
ChEMBL Inhibition of IL-1-beta-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of IL1-beta challenge by one stage clotting assay B 7.7 pIC50 20 nM IC50 J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
ChEMBL Inhibition of HOSCN-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of HOSCN challenge by one stage clotting assay B 7.7 pIC50 20 nM IC50 J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
Histone deacetylase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7]
ChEMBL Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells B 9.22 pIC50 0.6 nM IC50 J. Med. Chem. (2009) 52: 2185-2187 [PMID:19317450]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL Inhibition of human recombinant HDAC1 by Michaelis-Menten equation analysis B 9.06 pKi 0.87 nM Ki ACS Med. Chem. Lett. (2013) 4: 757-761 [PMID:24900743]
ChEMBL Inhibition of recombinant HDAC1 B 9.64 pKi 0.23 nM Ki Eur. J. Med. Chem. (2010) 45: 2095-2116 [PMID:20223566]
ChEMBL Inhibition of human HDAC1 B 9.7 pKi 0.2 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of human HDAC1 B 9.7 pKi 0.2 nM Ki Bioorg. Med. Chem. (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL Inhibition of HDAC1 (unknown origin) B 9.7 pKi 0.2 nM Ki Eur J Med Chem (2018) 158: 620-706 [PMID:30245394]
GtoPdb - - 9.7 pKi 0.2 nM Ki Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1) B 4.6 pIC50 >25000 nM IC50 J. Med. Chem. (2003) 46: 820-830 [PMID:12593661]
ChEMBL Inhibition of HDAC1 by fluorescence assay B 5.41 pIC50 3900 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1218-1221 [PMID:21256006]
ChEMBL Inhibition of HDAC1 expressed in 293T cells B 6.72 pIC50 190 nM IC50 Bioorg. Med. Chem. (2008) 16: 437-445 [PMID:17900911]
ChEMBL Inhibition of human HDAC1 expressed in 293T cells B 7.44 pIC50 36.6 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 2982-2984 [PMID:18397826]
ChEMBL Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate by fluorimetric assay B 7.49 pIC50 32 nM IC50 Eur J Med Chem (2019) 162: 321-333 [PMID:30448419]
ChEMBL Inhibition of HDAC1 B 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 1558-1561 [PMID:17257837]
ChEMBL Inhibition of human HDAC1 using RHKKAc as substrate by fluorescence assay B 7.6 pIC50 24.9 nM IC50 Eur J Med Chem (2019) 162: 612-630 [PMID:30476825]
ChEMBL Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate measured after 30 mins by fluorescence assay B 7.64 pIC50 23 nM IC50 Eur J Med Chem (2018) 158: 620-706 [PMID:30245394]
ChEMBL Inhibition of HDAC1 (unknown origin) assessed as inhibition of fluorogenic peptide deacetylation B 7.64 pIC50 23 nM IC50 Bioorg Med Chem Lett (2016) 26: 5222-5228 [PMID:27717544]
ChEMBL Inhibition of human HDAC1 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. (2014) 22: 3850-3855 [PMID:24997578]
ChEMBL Inhibition of HDAC1 B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 997-999 [PMID:20045316]
ChEMBL Inhibition of HDAC1 by fluorimetric assay B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 6770-6772 [PMID:23021104]
ChEMBL Inhibition of HDAC1 B 7.68 pIC50 21 nM IC50 J. Med. Chem. (2006) 49: 4809-4812 [PMID:16884291]
ChEMBL Inhibition of human recombinant HDAC1 expressed in NIH3T3 cells B 7.68 pIC50 21 nM IC50 J. Med. Chem. (2007) 50: 5425-5438 [PMID:17929798]
ChEMBL Inhibitory concentration against histone deacetylase 1 B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 4427-4431 [PMID:16137884]
ChEMBL Inhibition of human histone deacetylase 1 prepared from 293T cells B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 5343-5346 [PMID:15454224]
ChEMBL Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence assay B 7.72 pIC50 19 nM IC50 Bioorg Med Chem (2018) 26: 1920-1928 [PMID:29519604]
ChEMBL Inhibition of HDAC1 in human SHSY5Y cells using MOCPAC as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis B 7.73 pIC50 18.8 nM IC50 Bioorg Med Chem Lett (2016) 26: 4955-4959 [PMID:27650925]
ChEMBL Inhibition of human HDAC1 B 7.8 pIC50 16 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 4895-4900 [PMID:17588744]
ChEMBL Inhibition of HDAC1 by fluorescent activity assay B 7.8 pIC50 16 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 5735-5738 [PMID:21875796]
ChEMBL Inhibition of human recombinant GST-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using MOCPAC as substrate after 4 hrs by UHPLC-ESI-MS/MS analysis B 7.8 pIC50 15.7 nM IC50 Bioorg Med Chem Lett (2016) 26: 4955-4959 [PMID:27650925]
ChEMBL Inhibition of human KDAC1 using [3H]acetyl histone H4 peptide substrate incubated for 60 mins by scintillation counting method B 7.82 pIC50 15 nM IC50 J. Med. Chem. (2016) 59: 1613-1633 [PMID:26681404]
ChEMBL Inhibition of HDAC1 (unknown origin) using Fluor de Lys substrate by fluorescence assay relative to control B 7.9 pIC50 12.5 nM IC50 Eur J Med Chem (2019) 168: 110-122 [PMID:30802729]
ChEMBL Inhibition of HDAC1 (unknown origin) using RHKK(Ac)AMC as substrate after 1 to 2 hrs by fluorescence assay B 7.91 pIC50 12.44 nM IC50 Eur J Med Chem (2018) 143: 2005-2014 [PMID:29150335]
ChEMBL Inhibition of human HDAC1 after 30 mins by fluorescence assay B 7.92 pIC50 12 nM IC50 J. Nat. Prod. (2012) 75: 285-289 [PMID:22276693]
ChEMBL Inhibition of human HDAC1 by ELISA B 7.92 pIC50 12 nM IC50 Eur J Med Chem (2018) 148: 73-85 [PMID:29454918]
ChEMBL Inhibition of human HDAC1 using RHKKAc peptide as substrate B 7.92 pIC50 12 nM IC50 J Med Chem (2018) 61: 7087-7102 [PMID:30028616]
ChEMBL Inhibition of HDAC1 by fluorometric assay B 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 6200-6204 [PMID:22932316]
ChEMBL Inhibition of human HDAC1 by fluorescence assay B 7.96 pIC50 10.9 nM IC50 J. Med. Chem. (2013) 56: 427-436 [PMID:23252603]
ChEMBL Inhibition of recombinant human HDAC1 using Cbz-Lys(TFAc)-AMC as substrate by fluorometric analysis B 8 pIC50 10 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 7067-7070 [PMID:20947351]
ChEMBL Inhibition of recombinant human HDAC1 using RHK-K(Ac) as substrate by homogeneous fluorescence release assay B 8 pIC50 10 nM IC50 Eur J Med Chem (2019) 161: 277-291 [PMID:30366254]
ChEMBL Inhibition of HDAC1 B 8 pIC50 9.9 nM IC50 Bioorg. Med. Chem. (2010) 18: 3925-3933 [PMID:20452226]
ChEMBL Inhibition of HDAC1 (unknown origin) using RHKK(Ac) fluorogenic acetylated peptide substrate by fluorometric assay B 8.04 pIC50 9.2 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 4320-4324 [PMID:26264503]
ChEMBL Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by substrate addition and further incubated for 2 hrs by fluorescence assay B 8.05 pIC50 9 nM IC50 J Med Chem (2019) 62: 8557-8577 [PMID:31414801]
ChEMBL Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 insect cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay B 8.05 pIC50 9 nM IC50 J Med Chem (2020) 63: 4256-4292 [PMID:32212730]
ChEMBL Inhibition of recombinant human HDAC1 by fluorimetry B 8.07 pIC50 8.5 nM IC50 J. Med. Chem. (2016) 59: 655-670 [PMID:26705137]
ChEMBL Inhibition of human recombinant HDAC1 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins B 8.09 pIC50 8.22 nM IC50 J. Med. Chem. (2011) 54: 4350-4364 [PMID:21548582]
ChEMBL Inhibition of human HDAC1 using RHKKAc as substrate by fluorescence assay B 8.11 pIC50 7.7 nM IC50 ACS Med Chem Lett (2017) 8: 510-515 [PMID:28523102]
ChEMBL Inhibition of HDAC1 (unknown origin) after 15 mins by fluorescence assay B 8.13 pIC50 7.4 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 5497-5501 [PMID:25455492]
ChEMBL Inhibition of human HDAC1 using fluorogenic tetrapeptide RHKKAc as substrate B 8.15 pIC50 7.12 nM IC50 Eur. J. Med. Chem. (2014) 79: 251-259 [PMID:24742384]
ChEMBL Inhibition of human HDAC1 by fluorimetric assay B 8.15 pIC50 7.12 nM IC50 J. Med. Chem. (2010) 53: 8387-8399 [PMID:21073160]
ChEMBL Inhibition of human HDAC1 B 8.15 pIC50 7 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2346-2349 [PMID:19285395]
ChEMBL Inhibition of human HDAC1 using RHKK(Ac) as substrate B 8.16 pIC50 6.9 nM IC50 Eur J Med Chem (2018) 150: 667-677 [PMID:29567459]
ChEMBL Inhibition of recombinant human HDAC1 using fluorogenic substrate by fluorescence assay B 8.16 pIC50 6.89 nM IC50 Eur J Med Chem (2017) 125: 1268-1278 [PMID:27886544]
ChEMBL HDAC enzyme inhibitionAssay: HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48 and Perez-Balado et al., 2007, J. Med. Chem., 50:2497-2505. Inhibition assays using nuclear extract were performed essentially as described in Herman et al., 2006, Nat. Chem. Biol., 2:551-558. Briefly, the purified HDACs or nuclear extract were incubated with an acetylated substrate in the absence of the compound to be assayed and with increasing concentrations of the compound. The rate of substrate deacetylation was measured under each condition, and half-maximal inhibitory concentration with regard to each HDAC was determined by standard means. B 8.17 pIC50 6.7 nM IC50 US-9265734-B2. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors (2016)
ChEMBL Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay B 8.18 pIC50 6.57 nM IC50 Eur. J. Med. Chem. (2016) 116: 126-135 [PMID:27060764]
ChEMBL Inhibition of human HDAC1 using Arg-His-Lys-Lys (Ac) as substrate incubated for 2 hrs by fluorescence assay B 8.21 pIC50 6.22 nM IC50 Eur J Med Chem (2019) 184: 111755-111755 [PMID:31627059]
ChEMBL Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3651-3656 [PMID:19457659]
ChEMBL Inhibition of HDAC1 B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 1926-1930 [PMID:22321215]
ChEMBL Inhibition of HADC1 (unknown origin) B 8.22 pIC50 6 nM IC50 J Med Chem (2020) 63: 23-39 [PMID:31415174]
ChEMBL Inhibition of human recombinant HDAC1 expressed in baculovirus/sf9 cells using RHKKAc as substrate B 8.3 pIC50 5 nM IC50 J. Med. Chem. (2013) 56: 6775-6791 [PMID:23905680]
ChEMBL Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate B 8.3 pIC50 5 nM IC50 J. Med. Chem. (2012) 55: 9891-9899 [PMID:23009203]
ChEMBL In vitro inhibition of partially purified recombinant human Histone deacetylase 1 B 8.3 pIC50 5 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 2847-2850 [PMID:11597413]
ChEMBL Inhibitory concentration against recombinant human Histone deacetylase 1 B 8.3 pIC50 5 nM IC50 J. Med. Chem. (2003) 46: 5097-5116 [PMID:14613312]
ChEMBL Inhibition against partially purified human histone deacetylase 1 (HDAC-1) B 8.3 pIC50 5 nM IC50 J. Med. Chem. (2002) 45: 2877-2885 [PMID:12061890]
ChEMBL Inhibition of human recombinant HDAC1 using p53 residues 379-382 (RHKKAc) as substrate B 8.31 pIC50 4.9 nM IC50 Bioorg. Med. Chem. (2013) 21: 5339-5354 [PMID:23820574]
ChEMBL Inhibition of HDAC1 (unknown origin) after 30 mins by fluorometric analysis B 8.37 pIC50 4.3 nM IC50 Bioorg. Med. Chem. (2013) 21: 4201-4209 [PMID:23719282]
ChEMBL Inhibition of HDAC1 B 8.4 pIC50 4 nM IC50 J. Med. Chem. (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL Inhibition of HDAC1 after 17 hrs B 8.4 pIC50 4 nM IC50 J. Med. Chem. (2008) 51: 4370-4373 [PMID:18642892]
ChEMBL Inhibition of HDAC1 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs B 8.4 pIC50 4 nM IC50 J. Med. Chem. (2010) 53: 1347-1356 [PMID:20055418]
ChEMBL Inhibition of human recombinant HDAC1 after 30 mins by fluorimetric assay B 8.48 pIC50 3.3 nM IC50 J. Med. Chem. (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL Inhibition of human HDAC1 using rhodamine as substrate after 1 hrs by fluorescence assay B 8.52 pIC50 3 nM IC50 Bioorg. Med. Chem. (2011) 19: 4626-4634 [PMID:21723733]
ChEMBL Inhibition of HDAC1 by in vitro deacetylation assay B 8.52 pIC50 3 nM IC50 Nat. Chem. Biol. (2010) 6: 25-33 [PMID:19966789]
ChEMBL Inhibition of human HDAC1 in presence of dithiothreitol by HDAC fluorescent assay B 8.64 pIC50 2.3 nM IC50 Eur. J. Med. Chem. (2012) 52: 111-122 [PMID:22465091]
ChEMBL Inhibition of recombinant full-length human HDAC1 using RHKK(Ac) as substrate measured after 2 hrs by fluorescence assay B 8.67 pIC50 2.14 nM IC50 Eur J Med Chem (2018) 158: 620-706 [PMID:30245394]
ChEMBL Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method B 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. (2015) 23: 6785-6793 [PMID:26481659]
ChEMBL Inhibition of human HDAC1 expressed in 293T cells B 8.72 pIC50 1.9 nM IC50 Bioorg. Med. Chem. (2007) 15: 7830-7839 [PMID:17881232]
ChEMBL Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay B 9.17 pIC50 0.68 nM IC50 ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL Inhibition of HDAC1 B 9.82 pIC50 0.15 nM IC50 Bioorg. Med. Chem. (2010) 18: 4103-4110 [PMID:20472442]
ChEMBL Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells. B 5.22 pEC50 6000 nM EC50 J. Med. Chem. (2003) 46: 4826-4829 [PMID:14584932]
ChEMBL Concentration of compound required for acetylation of histone-4 in human T24 cancer cells F 6 pEC50 1000 nM EC50 Bioorg. Med. Chem. Lett. (2001) 11: 2847-2850 [PMID:11597413]
histone deacetylase 1/Histone deacetylase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4001] [GtoPdb: 2658] [UniProtKB: O09106]
ChEMBL Binding affinity towards HDAC1 (Histone deacetylase 1) in mouse A20 cells, expressed as binding constant (pKi) B 8.97 pKi 1.07 nM Ki J. Med. Chem. (2002) 45: 1778-1784 [PMID:11960489]
ChEMBL Inhibitory activity against histone deacetylases (HDAC1) prepared from mouse melanoma B16/BL6 cells B 7.72 pIC50 19 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 2427-2431 [PMID:15109626]
ChEMBL In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells B 8.7 pIC50 2 nM IC50 J. Med. Chem. (2002) 45: 1778-1784 [PMID:11960489]
ChEMBL Inhibition of mouse Histone deacetylase 1 (HDAC1) receptor B 8.7 pIC50 2 nM IC50 J. Med. Chem. (2004) 47: 1351-1359 [PMID:14998325]
ChEMBL Inhibition of mouse HDAC1 B 8.7 pIC50 2 nM IC50 J. Med. Chem. (2004) 47: 1351-1359 [PMID:14998325]
ChEMBL Inhibition of mouse HDAC1 B 8.74 pIC50 1.8 nM IC50 J. Med. Chem. (2006) 49: 6046-6056 [PMID:17004718]
ChEMBL Inhibition of mouse liver HDAC1 B 8.74 pIC50 1.8 nM IC50 J. Med. Chem. (2008) 51: 1505-1529 [PMID:18247554]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
ChEMBL