ChEMBL ligand: CHEMBL505121
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993] There should be some charts here, you may need to enable JavaScript!
E1A binding protein p300/Histone acetyltransferase p300 in Human [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472] There should be some charts here, you may need to enable JavaScript!
lysine acetyltransferase 2B in Human [GtoPdb: 2737] [UniProtKB: Q92831] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
ChEMBL	Inhibition of recombinant Tip60 (1-513) expressed in Escherichia coli BL21 (DE3) by liquid scintillation	B	4.53	pIC50	29750	nM	IC50	Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310]
E1A binding protein p300/Histone acetyltransferase p300 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
ChEMBL	Inhibition of p300 (unknown origin)	B	7.72	pKi	19	nM	Ki	Medchemcomm (2012) 3: 135-161
ChEMBL	Inhibition of recombinant p300	B	6.01	pIC50	980	nM	IC50	Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310]
GtoPdb	-	-	6.3	pIC50	500	nM	IC50	Mol Cell (2000) 5: 589-95 [PMID:10882143]
ChEMBL	Inhibition of N-terminal His-tagged human recombinant p300 catalytic domain (1284-1673 residues) using histone H4-8 peptide and [14C]acetyl CoA as substrate pretreated with enzyme and H4-8 peptide for 10 mins followed by [14C]acetyl CoA addition for 5 to 10 mins by phosphor-imaging analysis	B	6.3	pIC50	500	nM	IC50	J Med Chem (2020) 63: 4716-4731 [PMID:32314924]
ChEMBL	Inhibition of full length recombinant human FLAG-tagged p300 expressed in baculovirus expression system using histone substrate incubated for 10 mins by radiometric gel assay	B	6.3	pIC50	500	nM	IC50	J Med Chem (2016) 59: 1249-1270 [PMID:26701186]
ChEMBL	Inhibition of recombinant FLAG-tagged human P300 expressed in Baculovirus expression system using histone peptide as substrate after 10 mins in presence of [14C]-acetyl CoA by phosphorimaging analysis	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2018) 26: 5397-5407 [PMID:30297119]
ChEMBL	Inhibition of recombinant human p300 using [14C]acetyl-CoA as substrate measured after 10 mins by phosphor imaging analysis	B	6.3	pIC50	500	nM	IC50	J Med Chem (2020) 63: 1337-1360 [PMID:31910017]
ChEMBL	Inhibition of recombinant full length p300 (unknown origin) using N-terminal H4-20 peptide substrate incubated for 7 mins by radiometric gel assay in presence of [14C]acetyl-CoA	B	7.3	pIC50	50	nM	IC50	J Med Chem (2016) 59: 1249-1270 [PMID:26701186]
ChEMBL	Inhibition of human recombinant C-terminal GST-tagged p300 (1195 to 1673 residues) expressed in competent Escherichia coli DH5alpha cells using histone substrate after 30 mins by scintillation counting method in presence of [3H]acetyl-CoA	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2016) 59: 1249-1270 [PMID:26701186]
lysine acetyltransferase 2B in Human [GtoPdb: 2737] [UniProtKB: Q92831]
GtoPdb	-	-	3.7	pIC50	200000	nM	IC50	Mol Cell (2000) 5: 589-95 [PMID:10882143]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]