zonisamide [Ligand Id: 7047] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL750 (PD-110843, Zonisamide, CI-912, Zonegran, AD-810)
  • AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
  • This target only has 1 pki data point
1 CHEMBL750_lig_chart_1 AGAP002992-PA Anopheles gambiae
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  • Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
2 CHEMBL750_lig_chart_2 Alpha carbonic anhydrase Stylophora pistillata
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  • Amine oxidase [flavin-containing] in Danio rerio [ChEMBL: CHEMBL1681610] [UniProtKB: Q6NSN2]
  • This target only has 1 pki data point
3 CHEMBL750_lig_chart_3 Amine oxidase [flavin-containing] Danio rerio
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  • Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
  • This target only has 1 pki data point
4 CHEMBL750_lig_chart_4 Astrosclerin-3 Astrosclera willeyana
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  • Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
  • This target only has 1 pki data point
5 CHEMBL750_lig_chart_5 Carbonate dehydratase Sulfurihydrogenibium sp. (strain YO3AOP1)
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  • Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
  • Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
  • Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
  • Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
  • Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
6 CHEMBL750_lig_chart_6 Carbonic anhydrase Mycobacterium tuberculosisStylophora pistillataCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Candida glabrata CBS 138Saccharomyces cerevisiae S288c
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  • Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
7 CHEMBL750_lig_chart_7 Carbonic anhydrase 1 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
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8 CHEMBL750_lig_chart_8 Carbonic anhydrase 15 Mouse
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  • Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
9 CHEMBL750_lig_chart_9 Carbonic anhydrase 2 Cryptococcus neoformans var. grubii
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  • Carbonic anhydrase 3 in Bovine [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4]
  • This target only has 1 pki data point
10 CHEMBL750_lig_chart_10 Carbonic anhydrase 3 Bovine
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  • Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
  • This target only has 1 pki data point
11 CHEMBL750_lig_chart_11 Carbonic anhydrase, alpha family Thiomicrospira crunogena (strain XCL-2)
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
12 CHEMBL750_lig_chart_12 Carbonic anhydrase I Human
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
13 CHEMBL750_lig_chart_13 Carbonic anhydrase II Human
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
14 CHEMBL750_lig_chart_14 Carbonic anhydrase IV Human
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
15 CHEMBL750_lig_chart_15 Carbonic anhydrase IX Human
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
16 CHEMBL750_lig_chart_16 Carbonic anhydrase VA Human
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17 CHEMBL750_lig_chart_17 Carbonic anhydrase VB Human
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18 CHEMBL750_lig_chart_18 Carbonic anhydrase VI Human
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
19 CHEMBL750_lig_chart_19 Carbonic anhydrase VII Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
20 CHEMBL750_lig_chart_20 Carbonic anhydrase XII Human
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
  • This target only has 1 pki data point
21 CHEMBL750_lig_chart_21 Carbonic anhydrase XIII Human
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
22 CHEMBL750_lig_chart_22 Carbonic anhydrase XIV Human
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  • Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
  • This target only has 1 pki data point
23 CHEMBL750_lig_chart_23 Delta carbonic anhydrase Thalassiosira weissflogii
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24 CHEMBL750_lig_chart_24 Monoamine oxidase B HumanRat
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  • PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
  • This target only has 1 pki data point
25 CHEMBL750_lig_chart_25 PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Mycobacterium tuberculosis
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  • Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
  • This target only has 1 pki data point
26 CHEMBL750_lig_chart_26 Uncharacterized protein Rv1284/MT1322 Mycobacterium tuberculosis
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 6.58 pKi 263 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay B 6.59 pKi 259 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay B 6.59 pKi 259 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Amine oxidase [flavin-containing] in Danio rerio (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681610] [UniProtKB: Q6NSN2]
ChEMBL Competitive inhibition of zebrafish MAO by spectrophotometry B 4.51 pKi 30800 nM Ki J. Med. Chem. (2011) 54: 909-912 [PMID:21175212]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 6.78 pKi 165 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay B 6.85 pKi 140 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay B 6.06 pKi 876 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay B 6.19 pKi 645 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay B 6.03 pKi 942 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 6.03 pKi 942 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay B 6.03 pKi 940 nM Ki J. Med. Chem. (2011) 54: 1682-1692 [PMID:21332115]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 6.94 pKi 114 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 2647-2652 [PMID:23511020]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay B 6.97 pKi 106 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay B 6.64 pKi 231 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL Inhibition of Helicobacter pylori recombinant CA B 6.66 pKi 218 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay B 6.2 pKi 634 nM Ki J. Med. Chem. (2009) 52: 646-654 [PMID:19193158]
ChEMBL Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assay B 6.2 pKi 634 nM Ki J. Med. Chem. (2010) 53: 850-854 [PMID:20028100]
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
ChEMBL Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 6.01 pKi 971 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay B 6.01 pKi 970 nM Ki J. Med. Chem. (2011) 54: 1682-1692 [PMID:21332115]
Carbonic anhydrase 3 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4]
ChEMBL Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis B 5.07 pKi 8510 nM Ki Eur. J. Med. Chem. (2012) 49: 68-73 [PMID:22245047]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay B 6.39 pKi 411 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis B 4.83 pKi 14800 nM Ki Eur. J. Med. Chem. (2012) 49: 68-73 [PMID:22245047]
ChEMBL Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate B 4.83 pKi 14800 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 1352-1357 [PMID:22230050]
GtoPdb - - 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2013) 21: 5973-82 [PMID:23965175]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method B 7.25 pKi 56 nM Ki J. Med. Chem. (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2009) 52: 646-654 [PMID:19193158]
ChEMBL Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL Inhibition of human cloned CA1 by CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 4624-4627 [PMID:18644716]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL Inhibition of human cloned CA1 by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2010) 53: 850-854 [PMID:20028100]
ChEMBL Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
ChEMBL Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL Inhibition of human recombinant full length CA1 preincubated for 15 mins by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2011) 19: 7003-7007 [PMID:22041171]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL Inhibition of human recombinant full length CA1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2015) 23: 526-531 [PMID:25533402]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
ChEMBL Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis B 7.25 pKi 56 nM Ki Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 7.25 pKi 56 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay B 7.25 pKi 56 nM Ki Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL Inhibition of human recombinant CA1 B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human carbonic anhydrase 2 B 7.32 pKd 47.6 nM Kd Bioorg. Med. Chem. (2007) 15: 4152-4158 [PMID:17420132]
ChEMBL Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assay B 5.17 pKi 6800 nM Ki J. Med. Chem. (2008) 51: 2518-2521 [PMID:18363349]
ChEMBL Inhibitory effect on human Carbonic anhydrase II B 5.37 pKi 4300 nM Ki J. Med. Chem. (2002) 45: 312-320 [PMID:11784136]
ChEMBL Inhibition of human carbonic anhydrase 2 esterase activity using 4-nitrophenylacetate as substrate B 5.97 pKi 1070 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis B 5.97 pKi 1070 nM Ki Eur. J. Med. Chem. (2012) 49: 68-73 [PMID:22245047]
ChEMBL Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 6.52 pKi 303 nM Ki Bioorg. Med. Chem. (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 7.17 pKi 68.1 nM Ki Bioorg. Med. Chem. (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method after 1 hr of incubation B 7.45 pKi 35.2 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 2315-2320 [PMID:15837316]
ChEMBL Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 7.46 pKi 35 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay B 7.46