zonisamide [Ligand Id: 7047] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL750 (AD-810, CI-912, Excegran, N03AX15, PD-110843, Zonegran, Zonisade, Zonisamide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] | ||||||||
| ChEMBL | Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.58 | pKi | 263 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] | ||||||||
| ChEMBL | Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay | B | 6.59 | pKi | 259 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay | B | 6.59 | pKi | 259 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Amine oxidase [flavin-containing] in Danio rerio (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681610] [UniProtKB: Q6NSN2] | ||||||||
| ChEMBL | Competitive inhibition of zebrafish MAO by spectrophotometry | B | 4.51 | pKi | 30800 | nM | Ki | J Med Chem (2011) 54: 909-912 [PMID:21175212] |
| Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] | ||||||||
| ChEMBL | Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 6.78 | pKi | 165 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] | ||||||||
| ChEMBL | Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 6.85 | pKi | 140 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] | ||||||||
| ChEMBL | Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay | B | 6.06 | pKi | 876 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] | ||||||||
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 6.19 | pKi | 645 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] | ||||||||
| ChEMBL | Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay | B | 6.03 | pKi | 942 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 6.03 | pKi | 942 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| ChEMBL | Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay | B | 6.03 | pKi | 940 | nM | Ki | J Med Chem (2011) 54: 1682-1692 [PMID:21332115] |
| Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] | ||||||||
| ChEMBL | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | B | 6.94 | pKi | 114 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020] |
| Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay | B | 6.97 | pKi | 106 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] | ||||||||
| ChEMBL | Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay | B | 6.64 | pKi | 231 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of Helicobacter pylori recombinant CA | B | 6.66 | pKi | 218 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay | B | 6.2 | pKi | 634 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assay | B | 6.2 | pKi | 634 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] | ||||||||
| ChEMBL | Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 6.01 | pKi | 971 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| ChEMBL | Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay | B | 6.01 | pKi | 970 | nM | Ki | J Med Chem (2011) 54: 1682-1692 [PMID:21332115] |
| Carbonic anhydrase 3 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4] | ||||||||
| ChEMBL | Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis | B | 5.07 | pKi | 8510 | nM | Ki | Eur J Med Chem (2012) 49: 68-73 [PMID:22245047] |
| Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] | ||||||||
| ChEMBL | Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 6.39 | pKi | 411 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate | B | 4.83 | pKi | 14800 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis | B | 4.83 | pKi | 14800 | nM | Ki | Eur J Med Chem (2012) 49: 68-73 [PMID:22245047] |
| ChEMBL | Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay | B | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2021) 64: 3100-3114 [PMID:33721499] |
| GtoPdb | - | - | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of human cloned CA1 by CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4624-4627 [PMID:18644716] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481] |
| ChEMBL | Inhibition of human cloned CA1 by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2009) 52: 6421-6432 [PMID:19827837] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| ChEMBL | Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369] |
| ChEMBL | Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2011) 54: 1682-1692 [PMID:21332115] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2011) 54: 3977-3981 [PMID:21506569] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant full length CA1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2011) 19: 7003-7007 [PMID:22041171] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human recombinant full length CA1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2012) 55: 3891-3899 [PMID:22443141] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human recombinant CA1 | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 2 | B | 7.32 | pKd | 47.6 | nM | Kd | Bioorg Med Chem (2007) 15: 4152-4158 [PMID:17420132] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assay | B | 5.17 | pKi | 6800 | nM | Ki | J Med Chem (2008) 51: 2518-2521 [PMID:18363349] |
| ChEMBL | Inhibitory effect on human Carbonic anhydrase II | B | 5.37 | pKi | 4300 | nM | Ki | J Med Chem (2002) 45: 312-320 [PMID:11784136] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis | B | 5.97 | pKi | 1070 | nM | Ki | Eur J Med Chem (2012) 49: 68-73 [PMID:22245047] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 esterase activity using 4-nitrophenylacetate as substrate | B | 5.97 | pKi | 1070 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050] |
| ChEMBL | Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 6.52 | pKi | 303 | nM | Ki | Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980] |
| ChEMBL | Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 7.17 | pKi | 68.1 | nM | Ki | Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980] |
| ChEMBL | Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method after 1 hr of incubation | B | 7.45 | pKi | 35.2 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2315-2320 [PMID:15837316] |
| ChEMBL | Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of human cloned CA2 by CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4624-4627 [PMID:18644716] |
| ChEMBL | Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481] |
| ChEMBL | Inhibition of human cloned CA2 by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2009) 52: 6421-6432 [PMID:19827837] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369] |
| ChEMBL | Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2011) 54: 1682-1692 [PMID:21332115] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2011) 54: 3977-3981 [PMID:21506569] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant full length CA2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2011) 19: 7003-7007 [PMID:22041171] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| ChEMBL | Inhibition of human recombinant full length CA2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2012) 55: 3891-3899 [PMID:22443141] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA2 | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556] |
| ChEMBL | Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay | B | 7.98 | pKi | 10.4 | nM | Ki | J Med Chem (2021) 64: 3100-3114 [PMID:33721499] |
| ChEMBL | Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method | B | 7.99 | pKi | 10.3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2315-2320 [PMID:15837316] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 4 esterase activity using 4-nitrophenylacetate as substrate | B | 4.42 | pKi | 38450 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050] |
| ChEMBL | Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis | B | 4.42 | pKi | 38450 | nM | Ki | Eur J Med Chem (2012) 49: 68-73 [PMID:22245047] |
| ChEMBL | Inhibition of truncated human cloned membrane-associated carbonic anhydrase 4 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 5.07 | pKi | 8590 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571] |
| ChEMBL | Inhibition of human recombinant CA4 by stopped flow CO2 hydrase assay | B | 5.07 | pKi | 8590 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay | B | 8.29 | pKi | 5.1 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.29 | pKi | 5.1 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibitory constant against catalytic domain of human carbonic anhydrase IX | B | 8.29 | pKi | 5.1 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay | B | 8.29 | pKi | 5.1 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assay | B | 8.29 | pKi | 5.1 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| ChEMBL | Inhibition of human CA9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.29 | pKi | 5.1 | nM | Ki | Bioorg Med Chem (2011) 19: 7003-7007 [PMID:22041171] |
| ChEMBL | Inhibition of human recombinant CA9 catalytic domain-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | B | 8.29 | pKi | 5.1 | nM | Ki | J Med Chem (2012) 55: 3891-3899 [PMID:22443141] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay | B | 8.3 | pKi | 5 | nM | Ki | J Med Chem (2006) 49: 5544-5551 [PMID:16942027] |
| ChEMBL | Inhibition of human cloned CA9 catalytic domain by stopped flow CO2 hydration assay | B | 8.3 | pKi | 5 | nM | Ki | J Med Chem (2009) 52: 6421-6432 [PMID:19827837] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 5A | B | 7.69 | pKd | 20.6 | nM | Kd | Bioorg Med Chem (2007) 15: 4152-4158 [PMID:17420132] |
| ChEMBL | Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5A pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.7 | pKi | 20000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571] |
| ChEMBL | Inhibition of human recombinant CA5A by CO2 hydration assay | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4624-4627 [PMID:18644716] |
| ChEMBL | Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5A by stopped-flow CO2 hydration assay | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481] |
| ChEMBL | Inhibition of human recombinant CA5A by stopped flow CO2 hydrase assay | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| ChEMBL | Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5B preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 2.22 | pKi | 6033000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571] |
| ChEMBL | Inhibition of human recombinant CA5B by CO2 hydration assay | B | 5.22 | pKi | 6033 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4624-4627 [PMID:18644716] |
| ChEMBL | Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5B by stopped-flow CO2 hydration assay | B | 5.22 | pKi | 6033 | nM | Ki | Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481] |
| ChEMBL | Inhibition of human recombinant CA5B by stopped flow CO2 hydrase assay | B | 5.22 | pKi | 6033 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| ChEMBL | Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay | B | 5.22 | pKi | 6033 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 6 esterase activity using 4-nitrophenylacetate as substrate | B | 5.62 | pKi | 2420 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050] |
| ChEMBL | Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis | B | 5.62 | pKi | 2420 | nM | Ki | Eur J Med Chem (2012) 49: 68-73 [PMID:22245047] |
| ChEMBL | Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay | B | 7.05 | pKi | 89 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assay | B | 7.05 | pKi | 89 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| GtoPdb | - | - | 6.93 | pKi | 117 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay | B | 6.93 | pKi | 117 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method | B | 6.93 | pKi | 117 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663] |
| ChEMBL | Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assay | B | 6.93 | pKi | 117 | nM | Ki | J Med Chem (2011) 54: 3977-3981 [PMID:21506569] |
| ChEMBL | Inhibition of human recombinant full length CA7-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | B | 6.93 | pKi | 117 | nM | Ki | J Med Chem (2012) 55: 3891-3899 [PMID:22443141] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.93 | pKi | 117 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 6.93 | pKi | 117 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.93 | pKi | 117 | nM | Ki | Eur J Med Chem (2014) 71: 105-111 [PMID:24287559] |
| ChEMBL | Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2021) 64: 3100-3114 [PMID:33721499] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibitory constant against catalytic domain of human carbonic anhydrase XII | B | 4.96 | pKi | 11000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibition of human cloned CA12 catalytic domain by stopped flow CO2 hydration assay | B | 4.96 | pKi | 11000 | nM | Ki | J Med Chem (2009) 52: 6421-6432 [PMID:19827837] |
| ChEMBL | Inhibition of human recombinant CA12 by stopped flow CO2 hydrase assay | B | 4.96 | pKi | 11000 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 4.96 | pKi | 11000 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay | B | 4.96 | pKi | 11000 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| GtoPdb | - | - | 4.96 | pKi | 11000 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay | B | 8.42 | pKi | 3.8 | nM | Ki | J Med Chem (2021) 64: 3100-3114 [PMID:33721499] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] | ||||||||
| ChEMBL | Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay | B | 6.37 | pKi | 430 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay | B | 5.28 | pKi | 5250 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibition of human recombinant CA14 by stopped flow CO2 hydrase assay | B | 5.28 | pKi | 5250 | nM | Ki | J Med Chem (2010) 53: 850-854 [PMID:20028100] |
| ChEMBL | Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assay | B | 5.28 | pKi | 5250 | nM | Ki | J Med Chem (2011) 54: 3977-3981 [PMID:21506569] |
| ChEMBL | Inhibition of human recombinant full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 5.28 | pKi | 5250 | nM | Ki | Bioorg Med Chem (2011) 19: 7003-7007 [PMID:22041171] |
| ChEMBL | Inhibition of human recombinant full length CA14-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay | B | 5.28 | pKi | 5250 | nM | Ki | J Med Chem (2012) 55: 3891-3899 [PMID:22443141] |
| Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] | ||||||||
| ChEMBL | Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.39 | pKi | 404 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] | ||||||||
| ChEMBL | Competitive inhibition of human MAO B by spectrophotometry | B | 5.51 | pKi | 3100 | nM | Ki | J Med Chem (2011) 54: 909-912 [PMID:21175212] |
| Monoamine oxidase B in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3050] [GtoPdb: 2490] [UniProtKB: Q8BW75] | ||||||||
| ChEMBL | Inhibition of MAO-B in mouse brain assessed as reduction in H2O2 production incubated for 30 mins using benzylamine as substrate by Amplex red reagent based fluorescence assay | B | 4.61 | pIC50 | 24800 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 126677-126677 [PMID:31537422] |
| Monoamine oxidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643] | ||||||||
| ChEMBL | Competitive inhibition of rat MAO B by spectrophotometry | B | 5.54 | pKi | 2900 | nM | Ki | J Med Chem (2011) 54: 909-912 [PMID:21175212] |
| PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay | B | 6.68 | pKi | 210 | nM | Ki | J Med Chem (2011) 54: 1682-1692 [PMID:21332115] |
| Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay | B | 4.54 | pKi | 28680 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
