Ca2+ [Ligand Id: 707] activity data from GtoPdb

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  • CaS receptor in Human [GtoPdb: 54] [UniProtKB: P41180]
  • CaS receptor in Mouse [GtoPdb: 54] [UniProtKB: Q9QY96]
  • CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 CaS receptor HumanMouseRat
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  • KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 KCa2.1 Human
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  • KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
  • KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 KCa2.2 HumanRat
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  • KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
  • KCa2.3 in Rat [GtoPdb: 383] [UniProtKB: P70605]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 KCa2.3 HumanRat
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  • KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554]
  • This target only has 0 pki data point
  • 0
5 _lig_chart_5 KCa3.1 Human
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  • KNa1.1 in Mouse [GtoPdb: 385] [UniProtKB: Q6ZPR4]
  • This target only has 0 pki data point
  • 0
6 _lig_chart_6 KNa1.1 Mouse
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  • TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62]
  • TRPC5 in Mouse [GtoPdb: 490] [UniProtKB: Q9QX29]
  • This target only has 0 pki data point
  • 0
7 _lig_chart_7 TRPC5 HumanMouse
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  • TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43]
  • This target only has 0 pki data point
  • 0
8 _lig_chart_8 TRPM4 Human
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  • TRPM5 in Mouse [GtoPdb: 497] [UniProtKB: Q9JJH7]
  • This target only has 0 pki data point
  • 0
9 _lig_chart_9 TRPM5 Mouse
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  • TRPM6 in Human [GtoPdb: 498] [UniProtKB: Q9BX84]
  • This target only has 0 pki data point
  • 0
10 _lig_chart_10 TRPM6 Human
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  • TRPP1 in Human [GtoPdb: 504] [UniProtKB: Q13563]
  • This target only has 0 pki data point
  • 0
11 _lig_chart_11 TRPP1 Human
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  • ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
  • This target only has 0 pki data point
  • 0
12 _lig_chart_12 ZAC Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CaS receptor in Human [GtoPdb: 54] [UniProtKB: P41180]
GtoPdb - - 2.4 pKd - - - J Biol Chem (1995) 270: 2755-63 [PMID:7531693]
CaS receptor in Mouse [GtoPdb: 54] [UniProtKB: Q9QY96]
GtoPdb - - 2.5 pKd - - - J Biol Chem (2005) 280: 40201-9 [PMID:16199532]
CaS receptor in Rat [GtoPdb: 54] [UniProtKB: P48442]
GtoPdb - - 2.5 pKd - - - Proc Natl Acad Sci USA (1995) 92: 131-5 [PMID:7816802]
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb - - 6.52 pEC50 300 nM EC50 Science (1996) 273: 1709-14 [PMID:8781233];
Nature (1998) 395: 503-7 [PMID:9774106]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb - - 6.5 pEC50 - - - Nature (1998) 395: 503-7 [PMID:9774106];
J Biol Chem (2005) 280: 41404-11 [PMID:16239218];
J Biol Chem (2000) 275: 39954-63 [PMID:10991935]
KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604]
GtoPdb - - 6.4 pEC50 - - - Science (1996) 273: 1709-14 [PMID:8781233];
J Gen Physiol (1998) 111: 565-81 [PMID:9524139]
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
GtoPdb - - 6.5 pEC50 - - - Nature (1998) 395: 503-7 [PMID:9774106];
Br J Pharmacol (2007) 151: 655-65 [PMID:17486140];
Mol Pharmacol (2004) 65: 788-801 [PMID:14978258]
KCa2.3 in Rat [GtoPdb: 383] [UniProtKB: P70605]
GtoPdb - - 6.2 pEC50 - - - Am J Physiol, Cell Physiol (2001) 280: C836-42 [PMID:11245600]
KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554]
GtoPdb - - 7 pEC50 - - - Proc Natl Acad Sci USA (1997) 94: 11651-6 [PMID:9326665];
Proc Natl Acad Sci USA (1997) 94: 11013-8 [PMID:9380751];
Am J Physiol, Cell Physiol (2000) 278: C570-81 [PMID:10712246];
J Biol Chem (1997) 272: 32723-6 [PMID:9407042];
J Gen Physiol (1993) 102: 601-30 [PMID:7505804]
KNa1.1 in Mouse [GtoPdb: 385] [UniProtKB: Q6ZPR4]
GtoPdb - - 6.5 pIC50 - - - J Gen Physiol (2006) 127: 205-15 [PMID:16446508]
TRPC5 in Human [GtoPdb: 490] [UniProtKB: Q9UL62]
GtoPdb - - 6.2 pEC50 635 nM EC50
TRPC5 in Mouse [GtoPdb: 490] [UniProtKB: Q9QX29]
GtoPdb - - 6 pEC50 - - - J Gen Physiol (2009) 133: 525-46 [PMID:19398778];
J Biol Chem (2009) 284: 34423-32 [PMID:19815560]
TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43]
GtoPdb - - 6.3 pEC50 500 nM EC50 J Biol Chem (2005) 280: 6423-33 [PMID:15590641];
EMBO J (2006) 25: 467-78 [PMID:16424899];
Mol Pharmacol (2006) 69: 1413-20 [PMID:16407466];
J Physiol (Lond.) (2004) 560: 753-65 [PMID:15331675]
TRPM5 in Mouse [GtoPdb: 497] [UniProtKB: Q9JJH7]
GtoPdb - - 6.2 pEC50 700 nM EC50 Cell Calcium (2005) 37: 267-78 [PMID:15670874];
Curr Biol (2003) 13: 1153-8 [PMID:12842017];
Proc Natl Acad Sci USA (2003) 100: 15160-5 [PMID:14657398]
TRPM6 in Human [GtoPdb: 498] [UniProtKB: Q9BX84]
GtoPdb - - 5.32 pIC50 4800 nM IC50
TRPP1 in Human [GtoPdb: 504] [UniProtKB: Q13563]
GtoPdb - - 6 pEC50 - - - Nat Cell Biol (2002) 4: 191-7 [PMID:11854751]
ZAC in Human [GtoPdb: 587] [UniProtKB: Q401N2]
GtoPdb - - 2.03 pIC50 - - - Biochem Pharmacol (2016) 103: 109-17 [PMID:26872532]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.