norgestimate [Ligand Id: 7091] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1200934 (Dexnorgestrel acetime, Norgestimate, NSC-759159, ORF 10131, ORF-10131, RWJ 10131, RWJ-10131)
  • TRPC3 in Human [GtoPdb: 488] [UniProtKB: Q13507]
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  • TRPC6 in Human [GtoPdb: 491] [UniProtKB: Q9Y210]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPC3 in Human [GtoPdb: 488] [UniProtKB: Q13507]
GtoPdb Norgestimate-induced inhibition of hTRPC3-mediated Ca2+ entry in transfected CHO cells stimulated with the OAG diacylglycerol analog. - 5.52 pKi 3000 nM Ki PLoS ONE (2012) 7: e35393 [PMID:22530015]
TRPC6 in Human [GtoPdb: 491] [UniProtKB: Q9Y210]
GtoPdb Norgestimate-induced inhibition of hTRPC6-mediated Ca2+ entry in transfected HEK-FITR cells stimulated with the OAG diacylglycerol analog. - 5.28 pIC50 5200 nM IC50 PLoS ONE (2012) 7: e35393 [PMID:22530015]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]