amlexanox [Ligand Id: 7113] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1096 (Amlexanox, AA-673, CHX-3673, Aphthasol)
  • GPR35/G-protein coupled receptor 35 in Human [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
  • This target only has 0 pki data point
1 CHEMBL1096_lig_chart_1 G-protein coupled receptor 35 Human
There should be some charts here, you may need to enable JavaScript!
  • inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
  • This target only has 0 pki data point
2 CHEMBL1096_lig_chart_2 Inhibitor of nuclear factor kappa B kinase epsilon subunit Human
There should be some charts here, you may need to enable JavaScript!
  • TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
  • This target only has 0 pki data point
3 CHEMBL1096_lig_chart_3 Serine/threonine-protein kinase TBK1 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay B 5.4 pEC50 4000 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
ChEMBL Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay B 5.29 pIC50 5128.61 nM IC50 Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002]
ChEMBL Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay B 5.29 pIC50 5100 nM IC50 Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002]
GtoPdb Inhibition of substrate phosphorylation. - 6 pIC50 1000 nM IC50 Nat. Med. (2013) 19: 313-21 [PMID:23396211]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
GtoPdb Inhibition of substrate phosphorylation. - 6 pIC50 1000 nM IC50 Nat. Med. (2013) 19: 313-21 [PMID:23396211]
ChEMBL Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay B 6.07 pIC50 851.14 nM IC50 Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002]
ChEMBL Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay B 6.07 pIC50 850 nM IC50 Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]