ChEMBL ligand: CHEMBL1096 (CHX 3673, Amlexanox, AA-673, CHX-3673, Aphthasol)
GPR35/G-protein coupled receptor 35 in Human [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] This target only has 0 pki data point 0 1 CHEMBL1096_lig_chart_1 G-protein coupled receptor 35 Human There should be some charts here, you may need to enable JavaScript!
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] This target only has 0 pki data point 0 2 CHEMBL1096_lig_chart_2 Inhibitor of nuclear factor kappa B kinase epsilon subunit Human There should be some charts here, you may need to enable JavaScript!
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] This target only has 0 pki data point 0 3 CHEMBL1096_lig_chart_3 Replicase polyprotein 1ab Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) There should be some charts here, you may need to enable JavaScript!
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] This target only has 0 pki data point 0 4 CHEMBL1096_lig_chart_4 Serine/threonine-protein kinase TBK1 Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL	Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay	B	5.4	pEC50	4000	nM	EC50	J Med Chem (2017) 60: 362-372 [PMID:27976894]
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
ChEMBL	Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay	B	5.29	pIC50	5128.61	nM	IC50	Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002]
ChEMBL	Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay	B	5.29	pIC50	5100	nM	IC50	Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002]
GtoPdb	Inhibition of substrate phosphorylation.	-	6	pIC50	1000	nM	IC50	Nat Med (2013) 19: 313-21 [PMID:23396211]
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7]
ChEMBL	MERS_3CL Pro protease inhibition IC50 by FRET kind of response from peptide substrate	F	5	pIC50	>10000	nM	IC50	Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
GtoPdb	Inhibition of substrate phosphorylation.	-	6	pIC50	1000	nM	IC50	Nat Med (2013) 19: 313-21 [PMID:23396211]
ChEMBL	Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay	B	6.07	pIC50	851.14	nM	IC50	Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002]
ChEMBL	Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay	B	6.07	pIC50	850	nM	IC50	Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]