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ChEMBL ligand: CHEMBL1096 (Amlexanox, AA-673, CHX-3673, Aphthasol) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] | ||||||||
ChEMBL | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay | B | 5.4 | pEC50 | 4000 | nM | EC50 | J Med Chem (2017) 60: 362-372 [PMID:27976894] |
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
ChEMBL | Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay | B | 5.29 | pIC50 | 5128.61 | nM | IC50 | Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002] |
ChEMBL | Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay | B | 5.29 | pIC50 | 5100 | nM | IC50 | Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002] |
GtoPdb | Inhibition of substrate phosphorylation. | - | 6 | pIC50 | 1000 | nM | IC50 | Nat. Med. (2013) 19: 313-21 [PMID:23396211] |
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] | ||||||||
GtoPdb | Inhibition of substrate phosphorylation. | - | 6 | pIC50 | 1000 | nM | IC50 | Nat. Med. (2013) 19: 313-21 [PMID:23396211] |
ChEMBL | Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay | B | 6.07 | pIC50 | 851.14 | nM | IC50 | Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002] |
ChEMBL | Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence of [gamma-33P]-ATP by radiometric kinase assay | B | 6.07 | pIC50 | 850 | nM | IC50 | Bioorg Med Chem (2018) 26: 5443-5461 [PMID:30270002] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]