apraclonidine [Ligand Id: 7117] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL647 (Iopidine, Iopidine 1%, Apraclonidine)
  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
1 CHEMBL647_lig_chart_1 Alpha-2a adrenergic receptor Human
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328]
  • This target only has 1 pki data point
2 CHEMBL647_lig_chart_2 Alpha-2b adrenergic receptor Rat
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
3 CHEMBL647_lig_chart_3 Alpha-2c adrenergic receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
GtoPdb - - 8.5 pKi 2.9 nM Ki J. Med. Chem. (1996) 39: 3533-8 [PMID:8784451]
ChEMBL Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamster ovary (CHO) cells B 8.54 pKi 2.9 nM Ki J. Med. Chem. (1996) 39: 3533-3538 [PMID:8784451]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328]
ChEMBL Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ovary (CHO) cells B 8.32 pKi 4.8 nM Ki J. Med. Chem. (1996) 39: 3533-3538 [PMID:8784451]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
GtoPdb - - 7.52 pKi 30 nM Ki J. Med. Chem. (1996) 39: 3533-8 [PMID:8784451]
ChEMBL Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cells B 7.52 pKi 30 nM Ki J. Med. Chem. (1996) 39: 3533-3538 [PMID:8784451]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]