chlorthalidone [Ligand Id: 7147] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1055 (Chlortalidone, Chlortalidonum, Chlorthalidone, G-33182, Hygroton, Natriuran, NSC-69200, Phthalamudine, Thalitone) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method | B | 6.46 | pKi | 348 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| GtoPdb | - | - | 6.46 | pKi | 348 | nM | Ki | |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method | B | 6.86 | pKi | 138 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| ChEMBL | DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) | B | 6.17 | pIC50 | 677 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA3 by stopped-flow CO2 hydration method | B | 4.96 | pKi | 11000 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method | B | 6.71 | pKi | 196 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| GtoPdb | - | - | 6.71 | pKi | 196 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-21 [PMID:19119014] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method | B | 7.64 | pKi | 23 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method | B | 6.04 | pKi | 917 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method | B | 5.87 | pKi | 1347 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| GtoPdb | - | - | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-21 [PMID:19119014] |
| ChEMBL | Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method | B | 8.35 | pKi | 4.5 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| GtoPdb | - | - | 8.35 | pKi | 4.5 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-21 [PMID:19119014] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| GtoPdb | - | - | 5.38 | pKi | 4130 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-21 [PMID:19119014] |
| ChEMBL | Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method | B | 5.38 | pKi | 4130 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
