chlorthalidone [Ligand Id: 7147] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1055 (Thalitone, G-33182, NSC-69200, Hygroton, Chlortalidone, Chlorthalidone)
  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
1 CHEMBL1055_lig_chart_1 Carbonic anhydrase I Human
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
  • This target only has 1 pki data point
2 CHEMBL1055_lig_chart_2 Carbonic anhydrase II Human
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  • Carbonic anhydrase III in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
  • This target only has 1 pki data point
3 CHEMBL1055_lig_chart_3 Carbonic anhydrase III Human
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
4 CHEMBL1055_lig_chart_4 Carbonic anhydrase IV Human
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
  • This target only has 1 pki data point
5 CHEMBL1055_lig_chart_5 Carbonic anhydrase IX Human
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
  • This target only has 1 pki data point
6 CHEMBL1055_lig_chart_6 Carbonic anhydrase VA Human
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  • Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
  • This target only has 1 pki data point
7 CHEMBL1055_lig_chart_7 Carbonic anhydrase VB Human
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  • Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
  • This target only has 1 pki data point
8 CHEMBL1055_lig_chart_8 Carbonic anhydrase VI Human
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
9 CHEMBL1055_lig_chart_9 Carbonic anhydrase VII Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
10 CHEMBL1055_lig_chart_10 Carbonic anhydrase XII Human
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
  • This target only has 1 pki data point
11 CHEMBL1055_lig_chart_11 Carbonic anhydrase XIII Mouse
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
12 CHEMBL1055_lig_chart_12 Carbonic anhydrase XIV Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method B 6.46 pKi 348 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
GtoPdb - - 6.46 pKi 348 nM Ki
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method B 6.86 pKi 138 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) B 6.17 pIC50 677 nM IC50 DrugMatrix in vitro pharmacology data
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL Inhibition of human recombinant full length CA3 by stopped-flow CO2 hydration method B 4.96 pKi 11000 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method B 6.71 pKi 196 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
GtoPdb - - 6.71 pKi 196 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-21 [PMID:19119014]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method B 7.64 pKi 23 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method B 6.04 pKi 917 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method B 8.05 pKi 9 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method B 5.87 pKi 1347 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
GtoPdb - - 8.55 pKi 2.8 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-21 [PMID:19119014]
ChEMBL Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method B 8.55 pKi 2.8 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method B 8.35 pKi 4.5 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
GtoPdb - - 8.35 pKi 4.5 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-21 [PMID:19119014]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method B 7.82 pKi 15 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
GtoPdb - - 5.38 pKi 4130 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-21 [PMID:19119014]
ChEMBL Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method B 5.38 pKi 4130 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]