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ChEMBL ligand: CHEMBL1055 (Thalitone, G-33182, NSC-69200, Hygroton, Chlortalidone, Chlorthalidone) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
ChEMBL | Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method | B | 6.46 | pKi | 348 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
GtoPdb | - | - | 6.46 | pKi | 348 | nM | Ki | |
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
ChEMBL | Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method | B | 6.86 | pKi | 138 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
ChEMBL | DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) | B | 6.17 | pIC50 | 677 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
ChEMBL | Inhibition of human recombinant full length CA3 by stopped-flow CO2 hydration method | B | 4.96 | pKi | 11000 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
ChEMBL | Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method | B | 6.71 | pKi | 196 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
GtoPdb | - | - | 6.71 | pKi | 196 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-21 [PMID:19119014] |
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
ChEMBL | Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method | B | 7.64 | pKi | 23 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
ChEMBL | Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method | B | 6.04 | pKi | 917 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
ChEMBL | Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method | B | 8.05 | pKi | 9 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
ChEMBL | Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method | B | 5.87 | pKi | 1347 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
GtoPdb | - | - | 8.55 | pKi | 2.8 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-21 [PMID:19119014] |
ChEMBL | Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
ChEMBL | Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method | B | 8.35 | pKi | 4.5 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
GtoPdb | - | - | 8.35 | pKi | 4.5 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-21 [PMID:19119014] |
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
ChEMBL | Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
GtoPdb | - | - | 5.38 | pKi | 4130 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-21 [PMID:19119014] |
ChEMBL | Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method | B | 5.38 | pKi | 4130 | nM | Ki | Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]