chlorthalidone | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

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chlorthalidone
Ligand Activity Charts

chlorthalidone [Ligand Id: 7147] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1055 (Thalitone, G-33182, NSC-69200, Hygroton, Chlortalidone, Chlorthalidone)
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase III in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method	B	6.46	pKi	348	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
GtoPdb	-	-	6.46	pKi	348	nM	Ki
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method	B	6.86	pKi	138	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA))	B	6.17	pIC50	677	nM	IC50	DrugMatrix in vitro pharmacology data
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL	Inhibition of human recombinant full length CA3 by stopped-flow CO2 hydration method	B	4.96	pKi	11000	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method	B	6.71	pKi	196	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
GtoPdb	-	-	6.71	pKi	196	nM	Ki	Bioorg Med Chem (2009) 17: 1214-21 [PMID:19119014]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method	B	7.64	pKi	23	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method	B	6.04	pKi	917	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method	B	8.05	pKi	9	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method	B	5.87	pKi	1347	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
GtoPdb	-	-	8.55	pKi	2.8	nM	Ki	Bioorg Med Chem (2009) 17: 1214-21 [PMID:19119014]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method	B	8.55	pKi	2.8	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method	B	8.35	pKi	4.5	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
GtoPdb	-	-	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem (2009) 17: 1214-21 [PMID:19119014]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method	B	7.82	pKi	15	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
GtoPdb	-	-	5.38	pKi	4130	nM	Ki	Bioorg Med Chem (2009) 17: 1214-21 [PMID:19119014]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method	B	5.38	pKi	4130	nM	Ki	Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]