calindol [Ligand Id: 719] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1801356 (Calindol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CaS receptor in Human [GtoPdb: 54] [UniProtKB: P41180] | ||||||||
| GtoPdb | - | - | 6.5 | pKd | - | - | - |
Bioorg Med Chem Lett (2004) 14: 3345-9 [PMID:15149704]; J Biol Chem (2004) 279: 18990-7 [PMID:14976203] |
| CaS receptor/Calcium sensing receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2516] [GtoPdb: 54] [UniProtKB: P48442] | ||||||||
| ChEMBL | Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one assay | F | 6.88 | pEC50 | 132 | nM | EC50 | Bioorg Med Chem (2016) 24: 554-569 [PMID:26752095] |
| ChEMBL | Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one assay | F | 6.88 | pEC50 | 131.83 | nM | EC50 | Bioorg Med Chem (2016) 24: 554-569 [PMID:26752095] |
| GPRC6 receptor in Mouse [GtoPdb: 55] [UniProtKB: Q8K4Z6] | ||||||||
| GtoPdb | This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference). | - | 5 | pIC50 | ~10000 | nM | IC50 | Cell Calcium (2009) 46: 323-32 [PMID:19836834] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
