L-serine [Ligand Id: 726] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL11298 (L-serine, NSC-118365, Serine)
  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
  • This target only has 0 pki data point
  • 0
1 CHEMBL11298_lig_chart_1 Acetylcholinesterase Electrophorus electricus
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  • Amino acid transporter in Rat [ChEMBL: CHEMBL3562161] [UniProtKB: Q9Z1J7]
  • This target only has 0 pki data point
  • 0
2 CHEMBL11298_lig_chart_2 Amino acid transporter Rat
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  • Asc-type amino acid transporter 1 in Rat [ChEMBL: CHEMBL4105976] [GtoPdb: 901] [UniProtKB: P63116]
  • This target only has 0 pki data point
  • 0
3 CHEMBL11298_lig_chart_3 Asc-type amino acid transporter 1 Rat
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  • Cholinesterase in Equus caballus [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
  • This target only has 0 pki data point
  • 0
4 CHEMBL11298_lig_chart_4 Cholinesterase Equus caballus
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  • Gamma-glutamyltranspeptidase 1 in Rat [ChEMBL: CHEMBL2943] [UniProtKB: P07314]
  • This target only has 1 pki data point
  • 4.3
5 CHEMBL11298_lig_chart_5 Gamma-glutamyltranspeptidase 1 Rat
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  • Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8]
  • This target only has 1 pki data point
  • 1.54
6 CHEMBL11298_lig_chart_6 Proton-coupled amino acid transporter 1 Human
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  • GPRC6 receptor in Human [GtoPdb: 55] [UniProtKB: Q5T6X5]
  • This target only has 0 pki data point
  • 0
7 CHEMBL11298_lig_chart_7 GPRC6 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 30 mins by Ellman's method B 7.82 pIC50 15 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2654-2656 [PMID:25980913]
Amino acid transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3562161] [UniProtKB: Q9Z1J7]
ChEMBL Inhibition of ASCT2 mediated [3H]-L-serine uptake in rat hippocampal astrocytes after 5 mins by beta counting analysis B 4.03 pIC50 94000 nM IC50 US-8741955-B2. D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders (null)
ChEMBL Inhibition of ASCT2 mediated [3H]-D-serine uptake in rat hippocampal astrocytes B 4.24 pIC50 57900 nM IC50 US-8741955-B2. D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders (null)
Asc-type amino acid transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105976] [GtoPdb: 901] [UniProtKB: P63116]
ChEMBL Inhibition of asc-1 mediated [3H]-D-serine uptake in P2 fraction of rat forebrain synaptosomes after 4 mins by beta scintillation counting B 5.02 pIC50 9600 nM IC50 US-8741955-B2. D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders (null)
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL Inhibition of equine serum butyrylcholinesterase using butyrylthiocholineidioide as substrate preincubated for 20 mins followed by substrate addition measured for 30 mins by Ellman's method B 7.8 pIC50 16 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 2654-2656 [PMID:25980913]
Gamma-glutamyltranspeptidase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2943] [UniProtKB: P07314]
ChEMBL Inhibition of Rattus norvegicus Wistar (rat) rat Gamma-glutamyltranspeptidase using L-gamma-glutamyl-p-nitroanilide as substrate incubated for 15 min prior to substrate addition by spectrophotometric analysis B 4.3 pKi 50000 nM Ki Med Chem Res (2004) 13: 707-723
Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8]
ChEMBL Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting B 1.54 pKi -1.54 mM pKi Bioorg. Med. Chem. (2011) 19: 6409-6418 [PMID:21955456]
GPRC6 receptor in Human [GtoPdb: 55] [UniProtKB: Q5T6X5]
GtoPdb - - 3.2 pEC50 - - - Mol Pharmacol (2005) 67: 589-97 [PMID:15576628]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]