suprofen [Ligand Id: 7298] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL956 (NSC-303611, P-(2-thenoyl)hydratropic acid, P-2-thenoylhydratropic acid, Profenal, R-25061, R-25,061, Racemic suprofen, Srendam, Sulproltin, Suprofen, Sutoprofen, TN-762, Topalgic)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
GtoPdb - - 6.25 pIC50 560 nM IC50 Bioorg Med Chem Lett (2008) 18: 4655-7 [PMID:18667313]
ChEMBL Inhibition of COX1 in human whole blood B 6.25 pIC50 560 nM IC50 Bioorg Med Chem Lett (2008) 18: 4655-4657 [PMID:18667313]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 5.56 pIC50 2750 nM IC50 Bioorg Med Chem Lett (2008) 18: 4655-7 [PMID:18667313]
ChEMBL Inhibition of COX2 in human whole blood B 5.56 pIC50 2750 nM IC50 Bioorg Med Chem Lett (2008) 18: 4655-4657 [PMID:18667313]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]