ChEMBL ligand: CHEMBL1520 (BAY-389456, BAY38-9456, Levitra, Vardenafil, Vivanza)
Kv4.3/A-type voltage-gated potassium channel KCND3 in Human [ChEMBL: CHEMBL1964] [GtoPdb: 554] [UniProtKB: Q9UK17] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 10A/cAMP and cAMP-inhibited cGMP 3`,5`-cyclic phosphodiesterase 10A in Human [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 2A/cGMP-dependent 3`,5`-cyclic phosphodiesterase in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/cGMP-specific 3`,5`-cyclic phosphodiesterase in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 11A/Dual 3`,5`-cyclic-AMP and -GMP phosphodiesterase 11A in Human [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 9A/High affinity cGMP-specific 3`,5`-cyclic phosphodiesterase 9A in Human [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083] There should be some charts here, you may need to enable JavaScript!
Cav1.2/Voltage-dependent L-type calcium channel subunit alpha-1C in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] There should be some charts here, you may need to enable JavaScript!
Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv4.3/A-type voltage-gated potassium channel KCND3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1964] [GtoPdb: 554] [UniProtKB: Q9UK17]
ChEMBL	Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWorks Quattro automated patch clamp platform	F	4.1	pIC50	79432.82	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]
phosphodiesterase 10A/cAMP and cAMP-inhibited cGMP 3`,5`-cyclic phosphodiesterase 10A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4409] [GtoPdb: 1310] [UniProtKB: Q9Y233]
ChEMBL	Inhibition of PDE10 (unknown origin) using FAM-cGMP and FAM-cAMP as substrate after 60 mins by fluorescence assay	B	6.06	pIC50	880	nM	IC50	Eur J Med Chem (2013) 60: 285-294 [PMID:23313637]
ChEMBL	Inhibitory concentration against human phosphodiesterase 10	B	6.1	pIC50	790	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2365-2369 [PMID:15837326]
phosphodiesterase 2A/cGMP-dependent 3`,5`-cyclic phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL	Inhibition of human phosphodiesterase 2	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2365-2369 [PMID:15837326]
ChEMBL	Inhibition of PDE2 (unknown origin) using FAM-cGMP and FAM-cAMP as substrate after 60 mins by fluorescence assay	B	5.51	pIC50	3100	nM	IC50	Eur J Med Chem (2013) 60: 285-294 [PMID:23313637]
phosphodiesterase 5A/cGMP-specific 3`,5`-cyclic phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL	Inhibition of human phosphodiesterase 5	B	9	pKi	1	nM	Ki	J Med Chem (2005) 48: 3449-3462 [PMID:15887951]
ChEMBL	Inhibition of PDE5 (unknown origin)	B	9.15	pKi	0.7	nM	Ki	Eur J Med Chem (2018) 158: 767-780 [PMID:30245400]
ChEMBL	Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assay	B	9	pIC50	1	nM	IC50	Eur J Med Chem (2013) 60: 285-294 [PMID:23313637]
ChEMBL	Inhibition of recombinant human PDE5A	B	9.05	pIC50	0.89	nM	IC50	J Med Chem (2016) 59: 8967-9004 [PMID:27606546]
ChEMBL	Inhibition of PDE5A (unknown origin)	B	9.05	pIC50	0.89	nM	IC50	Eur J Med Chem (2018) 150: 506-524 [PMID:29549837]
ChEMBL	Inhibition of PDE5	B	9.15	pIC50	0.71	nM	IC50	Bioorg Med Chem (2008) 16: 7599-7606 [PMID:18656371]
ChEMBL	Inhibition of Phosphodiesterase 5 from human platelets	B	9.15	pIC50	0.7	nM	IC50	J Med Chem (2003) 46: 457-460 [PMID:12570368]
ChEMBL	Inhibition of PDE5 (unknown origin)	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2018) 61: 6421-6467 [PMID:29620890]
ChEMBL	Inhibition of human phosphodiesterase 5	B	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2365-2369 [PMID:15837326]
GtoPdb	-	-	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2365-9 [PMID:15837326]
ChEMBL	Inhibition of PDE5A1 (unknwon origin) using [3H]cGMP as substrate after 30 mins by SPA	B	9.77	pIC50	0.17	nM	IC50	J Med Chem (2018) 61: 1001-1018 [PMID:29293004]
ChEMBL	Inhibition of human platelets derived PDE5 using [3H]-cGMP as substrate incubated for 60 min by scintillation proximity assay	B	10.54	pIC50	0.03	nM	IC50	J Med Chem (2020) 63: 14243-14275 [PMID:32870008]
phosphodiesterase 11A/Dual 3`,5`-cyclic-AMP and -GMP phosphodiesterase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2717] [GtoPdb: 1311] [UniProtKB: Q9HCR9]
ChEMBL	Inhibition of PDE11 (unknown origin) using FAM-cGMP and FAM-cAMP as substrate after 60 mins by fluorescence assay	B	6.62	pIC50	240	nM	IC50	Eur J Med Chem (2013) 60: 285-294 [PMID:23313637]
ChEMBL	Inhibition of human phosphodiesterase 11	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2365-2369 [PMID:15837326]
phosphodiesterase 9A/High affinity cGMP-specific 3`,5`-cyclic phosphodiesterase 9A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3535] [GtoPdb: 1309] [UniProtKB: O76083]
ChEMBL	Inhibition of PDE9 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assay	B	6.17	pIC50	680	nM	IC50	Eur J Med Chem (2013) 60: 285-294 [PMID:23313637]
ChEMBL	Inhibition of Phosphodiesterase 9	B	6.34	pIC50	460	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2365-2369 [PMID:15837326]
Cav1.2/Voltage-dependent L-type calcium channel subunit alpha-1C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
ChEMBL	Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automated patch clamp platform	F	4.8	pIC50	15848.93	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]
Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform	F	4.1	pIC50	79432.82	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]
ChEMBL	Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay	F	4.5	pIC50	31622.78	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]