florbetapir [Ligand Id: 7344] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1774461 (18f-av45, (18F)AV-45, 18F-AV-45, Amyvid, Av45 f-18, AV-45 F-18, Florbetapir (18f), Florbetapir(18-f), Florbetapir f 18, Florbetapir f-18, Florbetapir, f-18) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
| ChEMBL | Binding affinity to human amyloid beta plaque | B | 8.54 | pKi | 2.9 | nM | Ki | ACS Med Chem Lett (2012) 3: 265-267 [PMID:24936237] |
| ChEMBL | Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain by competitive binding assay | B | 8.54 | pKi | 2.87 | nM | Ki | J Med Chem (2010) 53: 933-941 [PMID:19845387] |
| ChEMBL | Binding affinity to amyloid beta aggregates in postmortem human Alzheimer's disease brain homogenates after 2 hrs by gamma counting | B | 8.54 | pKi | 2.87 | nM | Ki | ACS Med Chem Lett (2011) 2: 673-677 [PMID:24900362] |
| ChEMBL | Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease patient brain homogenates after 1 hr | B | 8.54 | pKi | 2.87 | nM | Ki | J Med Chem (2011) 54: 8085-8098 [PMID:22011144] |
| ChEMBL | Binding affinity to amyloid beta (1-42) aggregates in human Alzheimer's disease brain sections | B | 8.54 | pKi | 2.87 | nM | Ki | J Med Chem (2012) 55: 883-892 [PMID:22236086] |
| ChEMBL | Displacement of [125I]IMPY from amyloid beta in brain homogenate of Alzheimer's disease patient after 2 hrs by gamma counting analysis | B | 8.54 | pKi | 2.87 | nM | Ki | Bioorg Med Chem (2013) 21: 3708-3714 [PMID:23673220] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
