florbetapir [Ligand Id: 7344] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1774461 (18f-av45, (18F)AV-45, 18F-AV-45, Amyvid, Av45 f-18, AV-45 F-18, Florbetapir (18f), Florbetapir(18-f), Florbetapir f 18, Florbetapir f-18, Florbetapir, f-18)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Binding affinity to human amyloid beta plaque B 8.54 pKi 2.9 nM Ki ACS Med Chem Lett (2012) 3: 265-267 [PMID:24936237]
ChEMBL Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain by competitive binding assay B 8.54 pKi 2.87 nM Ki J Med Chem (2010) 53: 933-941 [PMID:19845387]
ChEMBL Binding affinity to amyloid beta aggregates in postmortem human Alzheimer's disease brain homogenates after 2 hrs by gamma counting B 8.54 pKi 2.87 nM Ki ACS Med Chem Lett (2011) 2: 673-677 [PMID:24900362]
ChEMBL Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease patient brain homogenates after 1 hr B 8.54 pKi 2.87 nM Ki J Med Chem (2011) 54: 8085-8098 [PMID:22011144]
ChEMBL Binding affinity to amyloid beta (1-42) aggregates in human Alzheimer's disease brain sections B 8.54 pKi 2.87 nM Ki J Med Chem (2012) 55: 883-892 [PMID:22236086]
ChEMBL Displacement of [125I]IMPY from amyloid beta in brain homogenate of Alzheimer's disease patient after 2 hrs by gamma counting analysis B 8.54 pKi 2.87 nM Ki Bioorg Med Chem (2013) 21: 3708-3714 [PMID:23673220]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]