rilapladib [Ligand Id: 7376] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2104981 (Rilapladib, SB-659032)
  • PLA2-G7/LDL-associated phospholipase A2 in Human [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
PLA2-G7/LDL-associated phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3514] [GtoPdb: 1432] [UniProtKB: Q13093]
ChEMBL Inhibition of LpPLA2 (unknown origin) B 9.6 pIC50 0.25 nM IC50 ACS Med Chem Lett (2017) 8: 43-48 [PMID:28105273]
GtoPdb - - 9.64 pIC50 0.23 nM IC50 Curr Opin Lipidol (2009) 20: 415-20 [PMID:19667981]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]