ilomastat [Ligand Id: 7409] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL19611 (Ilomastat)
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  • MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
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  • MMP12/Matrix metalloproteinase 12 in Human [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900]
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  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
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  • MMP15/Matrix metalloproteinase 15 in Human [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511]
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  • MMP16/Matrix metalloproteinase 16 in Human [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512]
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  • MMP17/Matrix metalloproteinase 17 in Human [ChEMBL: CHEMBL2937] [GtoPdb: 1641] [UniProtKB: Q9ULZ9]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • MMP26/Matrix metalloproteinase 26 in Human [ChEMBL: CHEMBL4707] [GtoPdb: 1648] [UniProtKB: Q9NRE1]
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  • MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
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  • MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADAM10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5028] [GtoPdb: 1658] [UniProtKB: O14672]
ChEMBL Inhibition of ADAM10 B 6.58 pIC50 263 nM IC50 J. Med. Chem. (2009) 52: 5732-5747 [PMID:19715320]
GtoPdb Measured in an in vitro assay. - 8.09 pIC50 8.1 nM IC50 Bioorg Med Chem Lett (2004) 14: 6071-4 [PMID:15546732]
ChEMBL In vitro inhibition of A disintegrin and metalloprotease domain 10 (ADAM10) B 8.09 pIC50 8.1 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 6071-6074 [PMID:15546732]
ADAM12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5030] [GtoPdb: 1660] [UniProtKB: O43184]
ChEMBL Inhibition of A disintegrin and metalloprotease domain 12 (ADAM12) binding in cell based assay B 8.23 pIC50 5.93 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 6071-6074 [PMID:15546732]
GtoPdb Measured in a cell-based assay. - 8.23 pIC50 5.93 nM IC50 Bioorg Med Chem Lett (2004) 14: 6071-4 [PMID:15546732]
ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536]
ChEMBL Inhibition of TACE B 7.88 pIC50 13.1 nM IC50 J. Med. Chem. (2009) 52: 5732-5747 [PMID:19715320]
GtoPdb Measured in an in vitro assay. - 8.12 pIC50 7.5 nM IC50 Bioorg Med Chem Lett (2004) 14: 6071-4 [PMID:15546732]
ChEMBL In vitro inhibition of A disintegrin and metalloprotease domain 17 (ADAM17, TACE) B 8.12 pIC50 7.5 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 6071-6074 [PMID:15546732]
ADAM9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5982] [GtoPdb: 1657] [UniProtKB: Q13443]
ChEMBL Inhibition of ADAM9 B 7.25 pIC50 56.3 nM IC50 J. Med. Chem. (2009) 52: 5732-5747 [PMID:19715320]
GtoPdb Measured in an in vitro assay. - 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2004) 14: 6071-4 [PMID:15546732]
ChEMBL In vitro inhibition of A disintegrin and metalloprotease domain 9 (ADAM9) B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 6071-6074 [PMID:15546732]
ADAMTS4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173]
ChEMBL Inhibition of human recombinant ADAMTS4 expressed in HEk293 cells using FAM-AEwLQGRPISIAK-TAMRA as substrate measured for 15 mins by fluorometric analysis B 6.32 pIC50 480 nM IC50 Eur. J. Med. Chem. (2013) 62: 379-394 [PMID:23376997]
ADAMTS5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0]
ChEMBL Inhibition of human recombinant ADAMTS5 expressed in HEK293 cells using Abz-TESEwSRGAIY-Dpa-KK as substrate measured for 2 hrs by fluorometric analysis B 6.3 pIC50 500 nM IC50 Eur. J. Med. Chem. (2013) 62: 379-394 [PMID:23376997]
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL Evaluated for inhibitory activity against Human fibroblast collagenase (HFC) B 8.7 pKi 2 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 337-342
ChEMBL Inhibition of human fibroblast collagenase, matrix metalloprotease-1 B 8.7 pKi 2 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 349-352
GtoPdb - - 8.22 pIC50 6 nM IC50 Bioorg Med Chem Lett (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibition of matrix metalloprotease-1 (MMP-1) B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibitory activity against MMP1 B 8.22 pIC50 6 nM IC50 J. Med. Chem. (2006) 49: 456-458 [PMID:16420030]
ChEMBL Inhibition of MMP1 B 8.48 pIC50 3.3 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
ChEMBL Inhibition of human recombinant MMP1 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition measured every 15 secs for 15 mins by fluorometric analysis B 8.48 pIC50 3.3 nM IC50 Eur. J. Med. Chem. (2013) 62: 379-394 [PMID:23376997]
ChEMBL Inhibition of matrix metalloprotease-1 B 8.52 pIC50 3 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 1783-1786 [PMID:12729664]
ChEMBL Inhibition of human recombinant interstitial collagenase MMP-1 at 100 uM B 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 1637-1642
ChEMBL Inhibition of MMP1 B 8.82 pIC50 1.5 nM IC50 Bioorg. Med. Chem. (2007) 15: 4753-4766 [PMID:17512742]
ChEMBL Activity against Matrix metalloprotease-1 (MMP-1). B 8.82 pIC50 1.5 nM IC50 J. Med. Chem. (1998) 41: 1209-1217 [PMID:9548812]
ChEMBL Inhibition of human recombinant pro-MMP1 by spectrofluorimeter B 9.4 pIC50 0.4 nM IC50 Bioorg. Med. Chem. (2008) 16: 8745-8759 [PMID:18782669]
ChEMBL Inhibition of MMP1 B 9.7 pIC50 0.2 nM IC50 J. Med. Chem. (2011) 54: 4350-4364 [PMID:21548582]
MMP12/Matrix metalloproteinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900]
ChEMBL Inhibition of human recombinant MMP12 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 10 mins prior to substrate addition by spectrophotometry B 8.42 pKi 3.8 nM Ki MedChemComm (2013) 4: 432-442
ChEMBL Time dependent inhibition of human recombinant MMP12 by SPR assay B 9.28 pKi 0.52 nM Ki MedChemComm (2013) 4: 432-442
ChEMBL Inhibition of matrix metalloprotease-12 (MMP-12) B 7.89 pIC50 13 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibitory activity against MMP12 B 7.89 pIC50 13 nM IC50 J. Med. Chem. (2006) 49: 456-458 [PMID:16420030]
GtoPdb - - 7.89 pIC50 13 nM IC50 Bioorg Med Chem Lett (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibition of recombinant human MMP12 catalytic domain (Gly106 to Gly26 residues) expressed in Escherichia coli BL21 codon plus using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate by fluorescence assay B 8.28 pIC50 5.2 nM IC50 ACS Med Chem Lett (2018) 9: 137-142 [PMID:29456802]
ChEMBL Inhibition of MMP12 catalytic domain B 8.29 pIC50 5.1 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
ChEMBL Inhibition of MMP12 B 9 pIC50 1 nM IC50 J. Med. Chem. (2008) 51: 3449-3459 [PMID:18494455]
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL Inhibition of human recombinant MMP13 catalytic domain B 8.28 pIC50 5.2 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
ChEMBL Inhibition of human recombinant MMP13 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition measured every 15 secs for 15 mins by fluorometric analysis B 8.28 pIC50 5.2 nM IC50 Eur. J. Med. Chem. (2013) 62: 379-394 [PMID:23376997]
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL Inhibition of matrix metalloprotease-14 (MMP-14) B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibitory activity against MMP14 B 7.64 pIC50 23 nM IC50 J. Med. Chem. (2006) 49: 456-458 [PMID:16420030]
GtoPdb - - 7.64 pIC50 23 nM IC50 Bioorg Med Chem Lett (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibition of MMP14 B 7.87 pIC50 13.4 nM IC50 Bioorg. Med. Chem. (2007) 15: 4753-4766 [PMID:17512742]
ChEMBL Activity against deletion mutant of MT1-MMP lacking the transmembrane domain (deltaMT1) B 7.87 pIC50 13.4 nM IC50 J. Med. Chem. (1998) 41: 1209-1217 [PMID:9548812]
ChEMBL Inhibition of human recombinant MMP14 catalytic domain by spectrofluorimeter B 8.28 pIC50 5.2 nM IC50 Bioorg. Med. Chem. (2008) 16: 8745-8759 [PMID:18782669]
ChEMBL Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition measured every 15 secs for 15 mins by fluorometric analysis B 8.33 pIC50 4.7 nM IC50 Eur. J. Med. Chem. (2013) 62: 379-394 [PMID:23376997]
ChEMBL Inhibition of MMP14 catalytic domain B 8.33 pIC50 4.7 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
ChEMBL Inhibition of MMP14 B 9.39 pIC50 0.41 nM IC50 J. Med. Chem. (2011) 54: 4350-4364 [PMID:21548582]
MMP15/Matrix metalloproteinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511]
GtoPdb - - 8.1 pIC50 8 nM IC50 Bioorg Med Chem Lett (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibition of matrix metalloprotease-15 (MMP-15) B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibitory activity against MMP15 B 8.22 pIC50 6 nM IC50 J. Med. Chem. (2006) 49: 456-458 [PMID:16420030]
MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512]
ChEMBL Inhibition of matrix metalloprotease-16 (MMP-16) B 8.1 pIC50 8 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibitory activity against MMP16 B 8.1 pIC50 8 nM IC50 J. Med. Chem. (2006) 49: 456-458 [PMID:16420030]
GtoPdb - - 8.1 pIC50 8 nM IC50 Bioorg Med Chem Lett (2004) 14: 47-50 [PMID:14684295]
MMP17/Matrix metalloproteinase 17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2937] [GtoPdb: 1641] [UniProtKB: Q9ULZ9]
ChEMBL Inhibition of MMP17 catalytic domain B 8.47 pIC50 3.4 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
GtoPdb - - 8.47 pIC50 3.4 nM IC50 J Biol Chem (2007) 282: 27781-91 [PMID:17623656]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibition of Matrix metalloprotease-2 B 9.24 pKi 0.57 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 567-570 [PMID:11229773]
ChEMBL Binding affinity towards 72 kDa gelatinase (Matrix metalloprotease-2) B 9.41 pKi 0.39 nM Ki J. Med. Chem. (1998) 41: 199-223 [PMID:9457244]
ChEMBL Inhibition of MMP2 B 8 pIC50 10 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
ChEMBL Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition measured every 15 secs for 15 mins by fluorometric analysis B 8 pIC50 10 nM IC50 Eur. J. Med. Chem. (2013) 62: 379-394 [PMID:23376997]
GtoPdb - - 8.15 pIC50 7 nM IC50 Bioorg Med Chem Lett (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibition of matrix metalloprotease-2 (MMP-2) B 8.15 pIC50 7 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibitory activity against MMP2 B 8.15 pIC50 7 nM IC50 J. Med. Chem. (2006) 49: 456-458 [PMID:16420030]
ChEMBL Activity against Matrix metalloprotease-2 (MMP-2). B 8.96 pIC50 1.1 nM IC50 J. Med. Chem. (1998) 41: 1209-1217 [PMID:9548812]
ChEMBL Inhibition of MMP2 B 8.96 pIC50 1.1 nM IC50 Bioorg. Med. Chem. (2007) 15: 4753-4766 [PMID:17512742]
ChEMBL Inhibition of human recombinant MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 60 mins followed by substrate addition by fluorimetric analysis B 9.03 pIC50 0.94 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 2174-2178 [PMID:27038494]
ChEMBL Inhibition of human recombinant pro-MMP2 by spectrofluorimeter B 9.4 pIC50 0.4 nM IC50 Bioorg. Med. Chem. (2008) 16: 8745-8759 [PMID:18782669]
ChEMBL Inhibition of Matrix metalloprotease-2 B 9.4 pIC50 0.4 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 1783-1786 [PMID:12729664]
ChEMBL Inhibition of human matrix metalloprotease-2 B 9.98 pIC50 0.1 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2843-2846 [PMID:14611841]
MMP26/Matrix metalloproteinase 26 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4707] [GtoPdb: 1648] [UniProtKB: Q9NRE1]
ChEMBL Inhibition of matrix metalloprotease-26 (MMP-26) B 7.77 pIC50 17 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibitory activity against MMP26 B 7.77 pIC50 17 nM IC50 J. Med. Chem. (2006) 49: 456-458 [PMID:16420030]
GtoPdb - - 7.77 pIC50 17 nM IC50 Bioorg Med Chem Lett (2004) 14: 47-50 [PMID:14684295]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL Inhibition of human fibroblast stromelysin, matrix metalloprotease-3 B 7.34 pKi 46 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 349-352
ChEMBL Inhibition of Matrix metalloprotease-3 B 7.59 pKi 26 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 567-570 [PMID:11229773]
ChEMBL Inhibition of human recombinant matrix metalloprotease-3 (Stromelysin) at 100 uM B 7.55 pIC50 28 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 1637-1642
ChEMBL Inhibition of human recombinant MMP3 catalytic domain by spectrofluorimeter B 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. (2008) 16: 8745-8759 [PMID:18782669]
ChEMBL Inhibition of MMP3 B 8.12 pIC50 7.62 nM IC50 J. Med. Chem. (2011) 54: 4350-4364 [PMID:21548582]
ChEMBL Inhibition of MMP3 catalytic domain B 8.15 pIC50 7 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
ChEMBL Inhibition of MMP3 B 8.72 pIC50 1.9 nM IC50 Bioorg. Med. Chem. (2007) 15: 4753-4766 [PMID:17512742]
ChEMBL Activity against Matrix metalloprotease-3 (MMP-3). B 8.72 pIC50 1.9 nM IC50 J. Med. Chem. (1998) 41: 1209-1217 [PMID:9548812]
ChEMBL Inhibition of human matrix metalloprotease-3 B 9.72 pIC50 0.19 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2843-2846 [PMID:14611841]
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
ChEMBL Inhibition of MMP7 B 7.48 pIC50 33 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL Inhibition of human Matrix metalloprotease-8 B 9 pKi <1 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 349-352
ChEMBL The compound was tested for its binding affinity towards neutrophil collagenase (Matrix metalloprotease-8) B 9.74 pKi 0.18 nM Ki J. Med. Chem. (1998) 41: 199-223 [PMID:9457244]
ChEMBL Inhibition of MMP8 catalytic domain B 8.01 pIC50 9.7 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL Inhibition of human Matrix metalloprotease-9 B 9.16 pKi 0.69 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 349-352
ChEMBL The compound was tested for its binding affinity towards 92 kDa gelatinase (Matrix metalloprotease-9) B 9.24 pKi 0.57 nM Ki J. Med. Chem. (1998) 41: 199-223 [PMID:9457244]
GtoPdb - - 7.82 pIC50 15 nM IC50 Bioorg Med Chem Lett (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibition of matrix metalloprotease-9 (MMP-9) B 7.82 pIC50 15 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 47-50 [PMID:14684295]
ChEMBL Inhibitory activity against MMP9 B 7.82 pIC50 15 nM IC50 J. Med. Chem. (2006) 49: 456-458 [PMID:16420030]
ChEMBL Inhibition of MMP9 B 8.17 pIC50 6.7 nM IC50 J. Biol. Chem. (2007) 282: 27781-27791 [PMID:17623656]
ChEMBL Inhibition of human recombinant pro-MMP9 by spectrofluorimeter B 9.22 pIC50 0.6 nM IC50 Bioorg. Med. Chem. (2008) 16: 8745-8759 [PMID:18782669]
ChEMBL Inhibition of human recombinant MMP9 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 60 mins followed by substrate addition by fluorimetric analysis B 9.26 pIC50 0.55 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 2174-2178 [PMID:27038494]
ChEMBL Inhibition of MMP9 B 9.3 pIC50 0.5 nM IC50 Bioorg. Med. Chem. (2007) 15: 4753-4766 [PMID:17512742]
ChEMBL Activity against Matrix metalloprotease-9 (MMP-9). B 9.3 pIC50 0.5 nM IC50 J. Med. Chem. (1998) 41: 1209-1217 [PMID:9548812]
ChEMBL Inhibition of human recombinant 92 kDa gelatinase MMP-9 at 100 uM B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 1637-1642
ChEMBL Inhibition of MMP9 B 10.3 pIC50 0.05 nM IC50 J. Med. Chem. (2011) 54: 4350-4364 [PMID:21548582]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]