crofelemer [Ligand Id: 7453] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2108184 (Crofelemer, Fulyzaq, Mytesi, NP-303, Provir, SP-303, TRN-002, Virend)
  • CFTR in Human [GtoPdb: 707] [UniProtKB: P13569]
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  • CaCC in Human [GtoPdb: 708] [UniProtKB: Q5XXA6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CFTR in Human [GtoPdb: 707] [UniProtKB: P13569]
GtoPdb - - 5.15 pIC50 7000 nM IC50 Mol Pharmacol (2010) 77: 69-78 [PMID:19808995]
CaCC in Human [GtoPdb: 708] [UniProtKB: Q5XXA6]
GtoPdb - - 5.19 pIC50 6500 nM IC50 Mol Pharmacol (2010) 77: 69-78 [PMID:19808995]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]