crofelemer [Ligand Id: 7453] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2108184 (Crofelemer, Fulyzaq, Mytesi, NP-303, Provir, SP-303, TRN-002, Virend)
  • CFTR in Human [GtoPdb: 707] [UniProtKB: P13569]
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  • CaCC in Human [GtoPdb: 708] [UniProtKB: Q5XXA6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CFTR in Human [GtoPdb: 707] [UniProtKB: P13569]
GtoPdb - - 5.15 pIC50 7000 nM IC50 Mol Pharmacol (2010) 77: 69-78 [PMID:19808995]
CaCC in Human [GtoPdb: 708] [UniProtKB: Q5XXA6]
GtoPdb - - 5.19 pIC50 6500 nM IC50 Mol Pharmacol (2010) 77: 69-78 [PMID:19808995]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]