ChEMBL ligand: CHEMBL184412 (Dronedarone, SR33589, SR-33589)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] There should be some charts here, you may need to enable JavaScript!
Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	5.52	pIC50	3000	nM	IC50	Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL	Inhibition of human ERG	B	6.5	pIC50	316.23	nM	IC50	Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626]
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
ChEMBL	Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in guinea pig ventricular myocytes	F	6.4	pIC50	400	nM	IC50	IC50 data for the L-type calcium channel extracted from a set of literature articles
Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460]
GtoPdb	Whole cell patch clamp experiment using HEK293 cells expressing human Kv1.5.	-	5.63	pIC50	2370	nM	IC50	Eur J Med Chem (2014) 81: 89-94 [PMID:24824064]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]