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ChEMBL ligand: CHEMBL184412 (Dronedarone, SR33589, SR-33589) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibitory concentration against IKr potassium channel | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906] |
ChEMBL | Inhibition of human ERG | B | 6.5 | pIC50 | 316.23 | nM | IC50 | Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626] |
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] | ||||||||
ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in guinea pig ventricular myocytes | F | 6.4 | pIC50 | 400 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
GtoPdb | Whole cell patch clamp experiment using HEK293 cells expressing human Kv1.5. | - | 5.63 | pIC50 | 2370 | nM | IC50 | Eur J Med Chem (2014) 81: 89-94 [PMID:24824064] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]