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ChEMBL ligand: CHEMBL1363 (Arformoterol, Formoterol r,r-form) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
GtoPdb | - | - | 6.5 | pKi | 319 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 5302-7 [PMID:20655218] |
ChEMBL | Agonist activity at human beta1 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology | F | 6.96 | pEC50 | 109 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
GtoPdb | - | - | 8.59 | pKi | 2.6 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4705-10 [PMID:15324892] |
ChEMBL | Agonist activity at human beta2 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascreen technology | F | 8.58 | pEC50 | 2.63 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
ChEMBL | Agonist activity at beta2-adrenergic receptor (unknown origin) | F | 9.5 | pEC50 | 0.32 | nM | EC50 | Bioorg. Med. Chem. Lett. (2014) 24: 249-253 [PMID:24300734] |
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
ChEMBL | Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction | B | 9.89 | pEC50 | 0.13 | nM | EC50 | Bioorg. Med. Chem. Lett. (2014) 24: 249-253 [PMID:24300734] |
ChEMBL | Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction | B | 9.9 | pEC50 | 0.13 | nM | EC50 | Bioorg. Med. Chem. Lett. (2014) 24: 249-253 [PMID:24300734] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]