ChEMBL ligand: CHEMBL1215739
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993] There should be some charts here, you may need to enable JavaScript!
lysine acetyltransferase 8/Histone acetyltransferase KAT8 in Human [ChEMBL: CHEMBL1932912] [GtoPdb: 2668] [UniProtKB: Q9H7Z6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
ChEMBL	Competitive inhibition of human recombinant His-tagged Tip60 expressed in Escherichia coli BL21(DE3) cells by Michaelis-Menten equation in presence of Acetyl CoA	B	3.24	pKi	572	uM	Kii	Eur J Med Chem (2012) 47: 337-344 [PMID:22100137]
ChEMBL	Uncompetitive inhibition of human recombinant His-tagged Tip60 expressed in Escherichia coli BL21(DE3) cells by Michaelis-Menten equation in presence of peptide substrate H4	B	4.11	pKi	78	uM	Kii	Eur J Med Chem (2012) 47: 337-344 [PMID:22100137]
GtoPdb	-	-	4.13	pIC50	74000	nM	IC50	Eur J Med Chem (2012) 47: 337-44 [PMID:22100137]
ChEMBL	Inhibition of human recombinant His-tagged Tip60 expressed in Escherichia coli BL21(DE3) cells using [14C]Ac-AoA and histone H4 as substrate after 5 mins by scintillation counting	B	4.13	pIC50	74000	nM	IC50	Eur J Med Chem (2012) 47: 337-344 [PMID:22100137]
lysine acetyltransferase 8/Histone acetyltransferase KAT8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1932912] [GtoPdb: 2668] [UniProtKB: Q9H7Z6]
ChEMBL	Inhibition of human MOF expressed in Escherichia coli BL21(DE3) cells using [14C]AC-CoA and histone H4 as substrate after 5 mins by scintillation counting	B	4.33	pIC50	47000	nM	IC50	Eur J Med Chem (2012) 47: 337-344 [PMID:22100137]
GtoPdb	-	-	4.33	pIC50	47000	nM	IC50	Eur J Med Chem (2012) 47: 337-44 [PMID:22100137]
ChEMBL	Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of acetyl-CoA by alphascreen assay	B	4.57	pIC50	27000	nM	IC50	Eur J Med Chem (2018) 157: 867-876 [PMID:30145373]
ChEMBL	Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assay	B	4.82	pIC50	15000	nM	IC50	Eur J Med Chem (2018) 157: 867-876 [PMID:30145373]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]