ChEMBL ligand: CHEMBL356066 (Dacinostat, Laq-824, LAQ824, NVP-LAQ824)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 11/Histone deacetylase 11 in Human [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 5/Histone deacetylase 5 in Human [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 7/Histone deacetylase 7 in Human [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 9/Histone deacetylase 9 in Human [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG expressed in CHO cells by automated patch clamp electrophysiology assay	B	4.91	pIC50	12200	nM	IC50	J Med Chem (2010) 53: 2952-2963 [PMID:20205394]
ChEMBL	Inhibition of human ERG by automated patch clamp assay	B	4.99	pIC50	10300	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4909-4912 [PMID:21742496]
ChEMBL	Inhibition of human ERG by radioligand binding assay	B	4.99	pIC50	10300	nM	IC50	J Med Chem (2011) 54: 4752-4772 [PMID:21650221]
ChEMBL	Inhibition of human ERG by patch clamp assay	B	4.99	pIC50	10300	nM	IC50	J Med Chem (2011) 54: 4752-4772 [PMID:21650221]
ChEMBL	Inhibition of human ERG by manual patch clamp assay	B	4.99	pIC50	10300	nM	IC50	J Med Chem (2011) 54: 4752-4772 [PMID:21650221]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL	Inhibition of human HDAC1	B	9.22	pKi	0.6	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human HDAC1	B	9.26	pKi	0.55	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
GtoPdb	-	-	9.26	pKi	0.55	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of purified recombinant HDAC1	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4909-4912 [PMID:21742496]
ChEMBL	Inhibition of HDAC1	B	7.82	pIC50	15	nM	IC50	J Med Chem (2011) 54: 4752-4772 [PMID:21650221]
ChEMBL	Inhibition of FLAG-tagged HDAC1 expressed in HEK293 cells by fluorescent assay	B	8.05	pIC50	9	nM	IC50	J Med Chem (2010) 53: 2952-2963 [PMID:20205394]
ChEMBL	Inhibition of human recombinant HDAC1	B	8.1	pIC50	8	nM	IC50	J Med Chem (2007) 50: 5543-5546 [PMID:17941625]
ChEMBL	Inhibition of recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus after 10 mins by fluorimetric analysis	B	8.1	pIC50	8	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5684-5688 [PMID:19699639]
ChEMBL	Inhibition of C-terminal FLAG-tagged full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells after 3 hrs by FDL assay	B	8.3	pIC50	5	nM	IC50	Medchemcomm (2017) 8: 767-770 [PMID:30108795]
ChEMBL	Inhibition of human HDAC1 by fluorimetric assay	B	8.49	pIC50	3.23	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
ChEMBL	Inhibition of HDAC1 in HEK293 cells	B	8.59	pIC50	2.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
ChEMBL	Inhibition of human HDAC10 by fluorimetric assay	B	8.08	pIC50	8.41	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2]
ChEMBL	Inhibition of human HDAC11 by fluorimetric assay	B	8.25	pIC50	5.58	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
GtoPdb	-	-	8.85	pKi	1.4	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC2	B	8.85	pKi	1.4	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC2	B	8.85	pKi	1.4	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human HDAC2 by fluorimetric assay	B	7.8	pIC50	15.7	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
ChEMBL	Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysis	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5684-5688 [PMID:19699639]
ChEMBL	Inhibition of human recombinant HDAC2	B	8.15	pIC50	7	nM	IC50	J Med Chem (2007) 50: 5543-5546 [PMID:17941625]
ChEMBL	Inhibition of C-terminal FLAG-tagged full length recombinant human HDAC2 expressed in baculovirus infected Sf9 insect cells after 3 hrs by FDL assay	B	8.3	pIC50	5	nM	IC50	Medchemcomm (2017) 8: 767-770 [PMID:30108795]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL	Inhibition of human HDAC3	B	8.38	pKi	4.2	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC3	B	8.38	pKi	4.2	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	8.38	pKi	4.2	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC3 by fluorimetric assay	B	7.98	pIC50	10.5	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
ChEMBL	Inhibition of human recombinant HDAC3	B	8.05	pIC50	9	nM	IC50	J Med Chem (2007) 50: 5543-5546 [PMID:17941625]
ChEMBL	Inhibition of HDAC3 in HEK293 cells	B	8.44	pIC50	3.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of flag-tagged HDAC3	B	9.4	pIC50	0.4	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
ChEMBL	Inhibition of human HDAC4	B	5.65	pKi	2250	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC4	B	5.65	pKi	2250	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	5.65	pKi	2250	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human recombinant N-terminal FLAG-tagged HDAC4 (612-1034) expressed in baculovirus after 10 mins by fluorimetric analysis	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5684-5688 [PMID:19699639]
ChEMBL	Inhibition of wild type HDAC4 expressed in Escherichia coli	B	6.38	pIC50	420	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of human HDAC4 by fluorimetric assay	B	8.24	pIC50	5.82	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
ChEMBL	Inhibition of HDAC4 H976Y mutant expressed in Escherichia coli	B	8.36	pIC50	4.4	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of flag-tagged HDAC4 by pull-down assay	B	8.4	pIC50	4	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL	Inhibition of flag-tagged HDAC4 expressed in HEK293 cells by Biomol assay	B	8.52	pIC50	3	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL	Inhibition of HDAC4 catalytic domain expressed in HEK293 cells by Biomol assay	B	8.6	pIC50	2.5	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL	Inhibition of flag-tagged HDAC4	B	8.92	pIC50	1.2	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL	Inhibition of flag-tagged HDAC4 by Biomol assay	B	9	pIC50	1	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6]
ChEMBL	Inhibition of human HDAC5	B	6.38	pKi	420	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC5	B	6.38	pKi	420	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	6.38	pKi	420	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysis	B	6.72	pIC50	190	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5684-5688 [PMID:19699639]
ChEMBL	Inhibition of human HDAC5 by fluorimetric assay	B	8.25	pIC50	5.58	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
GtoPdb	-	-	8.02	pKi	9.5	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC6	B	8.02	pKi	9.5	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC6	B	8.02	pKi	9.5	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of HDAC6 in HEK293 cells	B	8.08	pIC50	8.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of human HDAC6 by fluorimetric assay	B	8.23	pIC50	5.93	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4]
GtoPdb	-	-	5.02	pKi	9500	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC7	B	5.02	pKi	9500	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC7	B	5.02	pKi	9500	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human recombinant N-terminal FLAG-tagged HDAC7 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysis	B	5.65	pIC50	2240	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5684-5688 [PMID:19699639]
ChEMBL	Inhibition of human HDAC7 by fluorimetric assay	B	8.21	pIC50	6.11	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL	Activity of human HDAC8	B	6.47	pKi	340	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC8	B	6.47	pKi	340	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	6.47	pKi	340	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human recombinant HDAC8	B	6.4	pIC50	400	nM	IC50	J Med Chem (2007) 50: 5543-5546 [PMID:17941625]
ChEMBL	Inhibition of human HDAC8 by fluorimetric assay	B	8.42	pIC50	3.84	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]
histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0]
ChEMBL	Inhibition of human HDAC9	B	5.05	pKi	9000	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC9	B	5.05	pKi	9000	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	5.05	pKi	9000	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC9 by fluorimetric assay	B	8.08	pIC50	8.24	nM	IC50	J Med Chem (2010) 53: 8387-8399 [PMID:21073160]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]