ChEMBL ligand: CHEMBL3086883
bromodomain adjacent to zinc finger domain 2B/Bromodomain adjacent to zinc finger domain protein 2B in Human [ChEMBL: CHEMBL1741220] [GtoPdb: 2722] [UniProtKB: Q9UIF8] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 3/Bromodomain-containing protein 3 in Human [ChEMBL: CHEMBL1795186] [GtoPdb: 2725] [UniProtKB: Q15059] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] bromodomain containing 4/Bromodomain-containing protein 4 in Mouse [ChEMBL: CHEMBL3085619] [GtoPdb: 1945] [UniProtKB: Q9ESU6] There should be some charts here, you may need to enable JavaScript!
bromodomain containing 7/Bromodomain-containing protein 7 in Human [ChEMBL: CHEMBL3085622] [GtoPdb: 2726] [UniProtKB: Q9NPI1] There should be some charts here, you may need to enable JavaScript!
CREB binding protein/CREB-binding protein in Human [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793] There should be some charts here, you may need to enable JavaScript!
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831] There should be some charts here, you may need to enable JavaScript!
bromodomain PHD finger transcription factor/Nucleosome-remodeling factor subunit BPTF in Human [ChEMBL: CHEMBL3085621] [GtoPdb: 2723] [UniProtKB: Q12830] There should be some charts here, you may need to enable JavaScript!
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4/Transcription activator BRG1 in Human [ChEMBL: CHEMBL3085620] [GtoPdb: 2740] [UniProtKB: P51532] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
bromodomain adjacent to zinc finger domain 2B/Bromodomain adjacent to zinc finger domain protein 2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741220] [GtoPdb: 2722] [UniProtKB: Q9UIF8]
ChEMBL	Displacement of fluorescein-labeled MS239 from recombinant human BAZ2b after 1 hr by fluorescence anisotropy assay	B	5.48	pKi	3290	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
bromodomain containing 3/Bromodomain-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795186] [GtoPdb: 2725] [UniProtKB: Q15059]
ChEMBL	Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD2 after 1 hr by fluorescence anisotropy assay	B	6.85	pKi	140	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
ChEMBL	Inhibition of human 6x-His-tagged BRD3 bromodomain 2 expressed in Escherichia coli	B	6.85	pKi	140	nM	Ki	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
ChEMBL	Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD1 after 1 hr by fluorescence anisotropy assay	B	7	pKi	100	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
ChEMBL	Inhibition of human 6x-His-tagged BRD3 bromodomain 1 expressed in Escherichia coli	B	7	pKi	100	nM	Ki	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
ChEMBL	Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD2 after 1 hr by fluorescence anisotropy assay	B	6.47	pKi	340	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
ChEMBL	Inhibition of human 6x-His-tagged BRD4 bromodomain 2 expressed in Escherichia coli	B	6.47	pKi	340	nM	Ki	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
ChEMBL	Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assay	B	7.07	pKi	85.11	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
ChEMBL	Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assay	B	7.07	pKi	<85	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
ChEMBL	Inhibition of human 6x-His-tagged BRD4 bromodomain 1 expressed in Escherichia coli	B	7.07	pKi	<85	nM	Ki	J Med Chem (2018) 61: 9316-9334 [PMID:30253095]
GtoPdb	Range of inhibition of binding across both Brd1 and Brd2 bromodomains of BRD4.	-	7.52	pKi	30	nM	Ki	J Med Chem (2013) 56: 9251-64 [PMID:24144283]
bromodomain containing 4/Bromodomain-containing protein 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3085619] [GtoPdb: 1945] [UniProtKB: Q9ESU6]
ChEMBL	Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated IL-6 expression preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by ELISA	B	5.31	pIC50	4900	nM	IC50	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
ChEMBL	Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated nitric oxide production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by spectrophotometric analysis	B	5.42	pIC50	3800	nM	IC50	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
bromodomain containing 7/Bromodomain-containing protein 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3085622] [GtoPdb: 2726] [UniProtKB: Q9NPI1]
ChEMBL	Displacement of fluorescein-labeled MS226 from recombinant human BRD7 after 1 hr by fluorescence anisotropy assay	B	5.57	pKi	2720	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
ChEMBL	Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assay	B	5.66	pKi	2180	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
ChEMBL	Displacement of fluorescein-labeled MS239 from recombinant human PCAF after 1 hr by fluorescence anisotropy assay	B	5.26	pKi	5520	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
bromodomain PHD finger transcription factor/Nucleosome-remodeling factor subunit BPTF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3085621] [GtoPdb: 2723] [UniProtKB: Q12830]
ChEMBL	Displacement of fluorescein-labeled MS239 from recombinant human BPTF after 1 hr by fluorescence anisotropy assay	B	5.22	pKi	6060	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4/Transcription activator BRG1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3085620] [GtoPdb: 2740] [UniProtKB: P51532]
ChEMBL	Displacement of fluorescein-labeled MS239 from recombinant human SMARCA4 bromodomain after 1 hr by fluorescence anisotropy assay	B	5.1	pKi	7970	nM	Ki	J Med Chem (2013) 56: 9251-9264 [PMID:24144283]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]