olodaterol [Ligand Id: 7543] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL605846 (BI 1744, Olodaterol, Striverdi respimat) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation | F | 6.91 | pEC50 | 123.03 | nM | EC50 | Eur J Med Chem (2021) 224: 113697-113697 [PMID:34273662] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| GtoPdb | - | - | 10 | pEC50 | 0.1 | nM | IC50 | J Pharmacol Exp Ther (2010) 334: 53-62 [PMID:20371707] |
| ChEMBL | Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation | F | 10.06 | pEC50 | 0.09 | nM | EC50 | Eur J Med Chem (2021) 224: 113697-113697 [PMID:34273662] |
| ChEMBL | Agonist activity at beta2 adrenoceptor (unknown origin) | F | 10.7 | pEC50 | 0.02 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
