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ChEMBL ligand: CHEMBL1472975 (Perospirone) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
GtoPdb | - | - | 4.74 | pKi | 18000 | nM | Ki | Proc Natl Acad Sci USA (1975) 72: 4376-80 [PMID:1060115] |
D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
GtoPdb | - | - | 9.22 | pKi | 0.6 | nM | Ki | Proc Natl Acad Sci USA (1975) 72: 4376-80 [PMID:1060115] |
D3 receptor in Human [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
GtoPdb | - | - | 9.55 | pKi | 0.28 | nM | Ki | Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163] |
D4 receptor in Human [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
GtoPdb | - | - | 10.05 | pKi | 0.09 | nM | Ki | Mol Psychiatry (1998) 3: 123-34 [PMID:9577836] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]