edoxaban [Ligand Id: 7575] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1269025 (DU-176, Edoxaban, Lixiana) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
| GtoPdb | - | - | 9.25 | pKi | 0.56 | nM | Ki |
J Med Chem (2010) 53: 6243-74 [PMID:20503967]; J Thromb Haemost (2008) 6: 1542-9 [PMID:18624979] |
| ChEMBL | Inhibition of factor Xa (unknown origin) assessed as inhibition constant | B | 9.25 | pKi | 0.56 | nM | Ki | Bioorg Med Chem Lett (2023) 80: 129127-129127 [PMID:36634753] |
| ChEMBL | Inhibition of factor 10a | B | 9.25 | pKi | 0.56 | nM | Ki | J Med Chem (2010) 53: 6243-6274 [PMID:20503967] |
| ChEMBL | Inhibition of human coagulation factor 10a using Z-D-Arg-Gly-Arg-pNA.2HCl as substrate preincubated for 15 mins followed by substrate addition by UV absorption assay | B | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 3813-3815 [PMID:30340898] |
| ChEMBL | Inhibition of human factor Xa using Z-D-Arg-Gly-Arg-pNA.2HCl as substrate preincubated for 15 mins followed by substrate addition by UV absorption analysis | B | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem (2019) 27: 1320-1326 [PMID:30792102] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
