ChEMBL ligand: CHEMBL33986 (Butorphanol, LEVO-BC-2627)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]Naltindole from human delta opioid receptor expressed in CHO cell membrane	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4474-4476 [PMID:18674902]
ChEMBL	Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
ChEMBL	Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cells after 3 hrs by scintillation counting	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells	B	9.66	pKi	0.22	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
GtoPdb	Displacement of [3H]U69593 from human κ opioid receptor expressed in CHO cells.	-	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4474-6 [PMID:18674902]
ChEMBL	Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cell membrane	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4474-4476 [PMID:18674902]
ChEMBL	Displacement of [3H]U69563 from human kappa-opioid receptor expressed in CHO cells after 60 mins by scintillation counting	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470]
ChEMBL	Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	8.54	pEC50	2.9	nM	EC50	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane	B	9.66	pKi	0.22	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4474-4476 [PMID:18674902]
ChEMBL	Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cells after 60 mins by scintillation counting	B	9.66	pKi	0.22	nM	Ki	Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470]
GtoPdb	Displacement of [3H]DAMGO from human μ opioid receptor expressed in CHO cells.	-	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4474-6 [PMID:18674902]
ChEMBL	Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells	B	9.92	pKi	0.12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]
ChEMBL	Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding	F	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]