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ChEMBL ligand: CHEMBL33986 (Butorphanol, LEVO-BC-2627) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
ChEMBL | Displacement of [3H]Naltindole from human delta opioid receptor expressed in CHO cell membrane | B | 7.92 | pKi | 12 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4474-4476 [PMID:18674902] |
ChEMBL | Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells | B | 7.92 | pKi | 12 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293] |
ChEMBL | Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cells after 3 hrs by scintillation counting | B | 7.92 | pKi | 12 | nM | Ki | Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells | B | 9.66 | pKi | 0.22 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293] |
GtoPdb | Displacement of [3H]U69593 from human κ opioid receptor expressed in CHO cells. | - | 9.92 | pKi | 0.12 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4474-6 [PMID:18674902] |
ChEMBL | Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cell membrane | B | 9.92 | pKi | 0.12 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4474-4476 [PMID:18674902] |
ChEMBL | Displacement of [3H]U69563 from human kappa-opioid receptor expressed in CHO cells after 60 mins by scintillation counting | B | 9.92 | pKi | 0.12 | nM | Ki | Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470] |
ChEMBL | Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay | F | 8.54 | pEC50 | 2.9 | nM | EC50 | Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane | B | 9.66 | pKi | 0.22 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4474-4476 [PMID:18674902] |
ChEMBL | Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cells after 60 mins by scintillation counting | B | 9.66 | pKi | 0.22 | nM | Ki | Bioorg Med Chem (2011) 19: 2808-2816 [PMID:21482470] |
GtoPdb | Displacement of [3H]DAMGO from human μ opioid receptor expressed in CHO cells. | - | 9.92 | pKi | 0.12 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4474-6 [PMID:18674902] |
ChEMBL | Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells | B | 9.92 | pKi | 0.12 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293] |
ChEMBL | Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding | F | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 203-208 [PMID:19027293] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]