ropivacaine [Ligand Id: 7602] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1077896 (Ropivacaine, TLC-590, TLC590, Tlc590)
  • K2P3.1/Potassium channel subfamily K member 3 in Human [ChEMBL: CHEMBL2321613] [GtoPdb: 515] [UniProtKB: O14649]
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  • Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
K2P3.1/Potassium channel subfamily K member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321613] [GtoPdb: 515] [UniProtKB: O14649]
ChEMBL Inhibition of human TASK1 expressed in Xenopus oocytes by whole cell voltage clamp assay B 4.28 pIC50 53000 nM IC50 J Med Chem (2019) 62: 10044-10058 [PMID:31260312]
Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524]
GtoPdb - - 3.49 pIC50 322200 nM IC50 Anesth Analg (2015) 120: 1226-34 [PMID:25692452]
GtoPdb - - 4.56 pIC50 27300 nM IC50 Anesth Analg (2015) 120: 1226-34 [PMID:25692452]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]