cromoglicic acid [Ligand Id: 7608] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL428880 (Cromo-comod, Cromoglicate, Cromoglicic acid, Cromoglycate, Cromolyn, R03BC01)
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  • TAS2R7 in Human [GtoPdb: 663] [UniProtKB: Q9NYW3]
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  • TAS2R20 in Human [GtoPdb: 671] [UniProtKB: P59543]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis B 5.63 pKi 2340 nM Ki J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay B 5.15 pEC50 7000 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
ChEMBL Agonist activity at human GPR35 by DMR assay B 6.28 pEC50 520 nM EC50 J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 by Ca+2 release assay B 6.68 pEC50 210 nM EC50 J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay B 7.28 pEC50 52 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
TAS2R7 in Human [GtoPdb: 663] [UniProtKB: Q9NYW3]
GtoPdb - - 2.35 pEC50 4500000 nM EC50 Chem Senses (2010) 35: 157-70 [PMID:20022913]
TAS2R20 in Human [GtoPdb: 671] [UniProtKB: P59543]
GtoPdb - - 4.35 pEC50 45000 nM EC50 Chem Senses (2010) 35: 157-70 [PMID:20022913]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]