cromoglicic acid [Ligand Id: 7608] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL428880 (Cromoglicic Acid, Cromolyn, R03BC01)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis B 5.63 pKi 2340 nM Ki J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay B 5.15 pEC50 7000 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
ChEMBL Agonist activity at human GPR35 by DMR assay B 6.28 pEC50 520 nM EC50 J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 by Ca+2 release assay B 6.68 pEC50 210 nM EC50 J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay B 7.28 pEC50 52 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]