BMS-599626 [Ligand Id: 7647] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1645462 (AC-480, Bms 599626, BMS-599626, AC480)
  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
  • This target only has 0 pki data point
1 CHEMBL1645462_lig_chart_1 Epidermal growth factor receptor erbB1 Human
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  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
2 CHEMBL1645462_lig_chart_2 HERG Human
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  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
  • This target only has 0 pki data point
3 CHEMBL1645462_lig_chart_3 Receptor protein-tyrosine kinase erbB-2 Human
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  • erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303]
  • This target only has 0 pki data point
4 CHEMBL1645462_lig_chart_4 Receptor protein-tyrosine kinase erbB-4 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb - - 7.49 pIC50 32 nM IC50 J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562]
ChEMBL Inhibition of human recombinant HER1 expressed in Sf9 cells by liquid scintillation counting B 7.49 pIC50 32 nM IC50 J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562]
ChEMBL Inhibition of EGFR B 7.49 pIC50 32 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 781-785 [PMID:21177105]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG expressed in HEK cells B 5.4 pIC50 4000 nM IC50 J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
GtoPdb - - 7.49 pIC50 22 nM IC50 J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562]
ChEMBL Inhibition of HER2 B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 781-785 [PMID:21177105]
ChEMBL Inhibition of human recombinant HER2 expressed in Sf9 cells by liquid scintillation counting B 7.66 pIC50 22 nM IC50 J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562]
erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303]
GtoPdb - - 6.72 pIC50 190 nM IC50 J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562]
ChEMBL Inhibition of human recombinant HER4 expressed in Sf9 cells by liquid scintillation counting B 6.72 pIC50 190 nM IC50 J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]