BMS-599626 [Ligand Id: 7647] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1645462 (AC-480, Bms 599626, BMS-599626, AC480)
  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
  • This target only has 0 pki data point
1 CHEMBL1645462_lig_chart_1 Epidermal growth factor receptor erbB1 Human
There should be some charts here, you may need to enable JavaScript!
  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
2 CHEMBL1645462_lig_chart_2 HERG Human
There should be some charts here, you may need to enable JavaScript!
  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
  • This target only has 0 pki data point
3 CHEMBL1645462_lig_chart_3 Receptor protein-tyrosine kinase erbB-2 Human
There should be some charts here, you may need to enable JavaScript!
  • erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303]
  • This target only has 0 pki data point
4 CHEMBL1645462_lig_chart_4 Receptor protein-tyrosine kinase erbB-4 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb - - 7.49 pIC50 32 nM IC50 J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562]
ChEMBL Inhibition of human recombinant HER1 expressed in Sf9 cells by liquid scintillation counting B 7.49 pIC50 32 nM IC50 J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562]
ChEMBL Inhibition of EGFR B 7.49 pIC50 32 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 781-785 [PMID:21177105]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG expressed in HEK cells B 5.4 pIC50 4000 nM IC50 J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
GtoPdb - - 7.49 pIC50 22 nM IC50 J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562]
ChEMBL Inhibition of HER2 B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 781-785 [PMID:21177105]
ChEMBL Inhibition of human recombinant HER2 expressed in Sf9 cells by liquid scintillation counting B 7.66 pIC50 22 nM IC50 J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562]
erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303]
GtoPdb - - 6.72 pIC50 190 nM IC50 J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562]
ChEMBL Inhibition of human recombinant HER4 expressed in Sf9 cells by liquid scintillation counting B 6.72 pIC50 190 nM IC50 J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]