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ChEMBL ligand: CHEMBL1645462 (AC-480, Bms 599626, BMS-599626, AC480) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
GtoPdb | - | - | 7.49 | pIC50 | 32 | nM | IC50 | J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562] |
ChEMBL | Inhibition of human recombinant HER1 expressed in Sf9 cells by liquid scintillation counting | B | 7.49 | pIC50 | 32 | nM | IC50 | J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562] |
ChEMBL | Inhibition of EGFR | B | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg. Med. Chem. Lett. (2011) 21: 781-785 [PMID:21177105] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG expressed in HEK cells | B | 5.4 | pIC50 | 4000 | nM | IC50 | J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
GtoPdb | - | - | 7.49 | pIC50 | 22 | nM | IC50 | J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562] |
ChEMBL | Inhibition of HER2 | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg. Med. Chem. Lett. (2011) 21: 781-785 [PMID:21177105] |
ChEMBL | Inhibition of human recombinant HER2 expressed in Sf9 cells by liquid scintillation counting | B | 7.66 | pIC50 | 22 | nM | IC50 | J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562] |
erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303] | ||||||||
GtoPdb | - | - | 6.72 | pIC50 | 190 | nM | IC50 | J. Med. Chem. (2009) 52: 6527-30 [PMID:19821562] |
ChEMBL | Inhibition of human recombinant HER4 expressed in Sf9 cells by liquid scintillation counting | B | 6.72 | pIC50 | 190 | nM | IC50 | J. Med. Chem. (2009) 52: 6527-6530 [PMID:19821562] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]