apatinib [Ligand Id: 7648] activity data from GtoPdb

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  • KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
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  • kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
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  • C-terminal Src kinase in Human [GtoPdb: 1994] [UniProtKB: P41240]
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  • ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
GtoPdb Assay used apatinib mesylate (YN968D1) - 6.37 pIC50 429 nM IC50 Cancer Sci. (2011) 102: 1374-80 [PMID:21443688]
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb Assay used apatinib mesylate (YN968D1) - 9 pIC50 1 nM IC50 Cancer Sci. (2011) 102: 1374-80 [PMID:21443688]
C-terminal Src kinase in Human [GtoPdb: 1994] [UniProtKB: P41240]
GtoPdb Assay used apatinib mesylate (YN968D1) - 6.28 pIC50 530 nM IC50 Cancer Sci. (2011) 102: 1374-80 [PMID:21443688]
ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949]
GtoPdb Assay used apatinib mesylate (YN968D1) - 7.89 pIC50 13 nM IC50 Cancer Sci. (2011) 102: 1374-80 [PMID:21443688]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.