rivoceranib [Ligand Id: 7648] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3186534 (Rivoceranib, Apatinib, YN968D1)
  • KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
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  • kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
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  • C-terminal Src kinase in Human [GtoPdb: 1994] [UniProtKB: P41240]
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  • ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
GtoPdb Assay used apatinib mesylate (YN968D1) - 6.37 pIC50 429 nM IC50 Cancer Sci. (2011) 102: 1374-80 [PMID:21443688]
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb Assay used apatinib mesylate (YN968D1) - 9 pIC50 1 nM IC50 Cancer Sci. (2011) 102: 1374-80 [PMID:21443688]
C-terminal Src kinase in Human [GtoPdb: 1994] [UniProtKB: P41240]
GtoPdb Assay used apatinib mesylate (YN968D1) - 6.28 pIC50 530 nM IC50 Cancer Sci. (2011) 102: 1374-80 [PMID:21443688]
ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949]
GtoPdb Assay used apatinib mesylate (YN968D1) - 7.89 pIC50 13 nM IC50 Cancer Sci. (2011) 102: 1374-80 [PMID:21443688]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]