blonanserin [Ligand Id: 7670] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL178803 (AD-5423, Blonanserin)
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb - - 9.85 pKi 0.14 nM Ki Bioorg Med Chem Lett (2005) 15: 1055-9 [PMID:15686911]
ChEMBL In vitro binding affinity against recombinant human dopamine receptor D2L in human liver microsomes B 9.85 pKi 0.14 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 1055-1059 [PMID:15686911]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 9.09 pKi 0.81 nM Ki Bioorg Med Chem Lett (2005) 15: 1055-9 [PMID:15686911]
ChEMBL In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes B 9.09 pKi 0.81 nM Ki Bioorg. Med. Chem. Lett. (2005) 15: 1055-1059 [PMID:15686911]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]