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ChEMBL ligand: CHEMBL1829433 (Azd 4877, Azd-4877, AZD-4877, AZD4877) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kinesin-1 heavy chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5864] [UniProtKB: P33176] | ||||||||
ChEMBL | Inhibition of human GST-conventional kinesin ATPase activity after 20 mins by malachite green assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2011) 54: 6734-6750 [PMID:21899292] |
kinesin-5/Kinesin-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4581] [GtoPdb: 2788] [UniProtKB: P52732] | ||||||||
ChEMBL | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | B | 6.37 | pIC50 | 429 | nM | IC50 | J Med Chem (2011) 54: 6734-6750 [PMID:21899292] |
ChEMBL | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2011) 54: 6734-6750 [PMID:21899292] |
GtoPdb | Measured as inhibition of ATPase activity of a 369 amino acid N-terminal fragment of hKIF11 | - | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2011) 54: 6734-50 [PMID:21899292] |
Kinesin-like protein KIF23 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5899] [UniProtKB: Q02241] | ||||||||
ChEMBL | Inhibition of human recombinant GST-MKLP1 after 20 mins by malachite green assay | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2011) 54: 6734-6750 [PMID:21899292] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]