SM-337 [Ligand Id: 7732] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL504559 (SM-337)
  • baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
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  • baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489]
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  • baculoviral IAP repeat containing 8/Baculoviral IAP repeat-containing protein 8 in Human [ChEMBL: CHEMBL5851] [GtoPdb: 2797] [UniProtKB: Q96P09]
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  • X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
GtoPdb Fluorescence polarization assay using hcIAP-1 BIR3 domain (residues 253-363) - 8.82 pKi 1.5 nM Ki J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL Displacement of fluorescently tagged SM5F from human cIAP-1 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay B 8.82 pKi 1.5 nM Ki J. Med. Chem. (2008) 51: 8158-8162 [PMID:19049347]
ChEMBL Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay B 8.89 pKi 1.3 nM Ki J. Med. Chem. (2010) 53: 6361-6367 [PMID:20684551]
ChEMBL Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay B 8.05 pIC50 9 nM IC50 J. Med. Chem. (2010) 53: 6361-6367 [PMID:20684551]
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489]
ChEMBL Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay B 8.2 pKi 6.3 nM Ki J. Med. Chem. (2010) 53: 6361-6367 [PMID:20684551]
GtoPdb Fluorescence polarization assay using hcIAP2 BIR3 domain (residues 238-349) - 8.38 pKi 4.2 nM Ki J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay B 7.58 pIC50 26.3 nM IC50 J. Med. Chem. (2010) 53: 6361-6367 [PMID:20684551]
baculoviral IAP repeat containing 8/Baculoviral IAP repeat-containing protein 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5851] [GtoPdb: 2797] [UniProtKB: Q96P09]
ChEMBL Displacement of fluorescently tagged SM5F from human cIAP-2 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay B 8.38 pKi 4.2 nM Ki J. Med. Chem. (2008) 51: 8158-8162 [PMID:19049347]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay B 6.96 pKi 110.9 nM Ki J. Med. Chem. (2010) 53: 6361-6367 [PMID:20684551]
GtoPdb Fluorescence polarization assay using hXIAP BIR3 domain (residues 241-356) - 7.59 pKi 26 nM Ki J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay B 6.43 pIC50 369.7 nM IC50 J. Med. Chem. (2010) 53: 6361-6367 [PMID:20684551]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]