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ChEMBL ligand: CHEMBL504559 (SM-337) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] | ||||||||
GtoPdb | Fluorescence polarization assay using hcIAP-1 BIR3 domain (residues 253-363) | - | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2008) 51: 8158-62 [PMID:19049347] |
ChEMBL | Displacement of fluorescently tagged SM5F from human cIAP-1 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2008) 51: 8158-8162 [PMID:19049347] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 8.89 | pKi | 1.3 | nM | Ki | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] | ||||||||
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
GtoPdb | Fluorescence polarization assay using hcIAP2 BIR3 domain (residues 238-349) | - | 8.38 | pKi | 4.2 | nM | Ki | J Med Chem (2008) 51: 8158-62 [PMID:19049347] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 7.58 | pIC50 | 26.3 | nM | IC50 | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
baculoviral IAP repeat containing 8/Baculoviral IAP repeat-containing protein 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5851] [GtoPdb: 2797] [UniProtKB: Q96P09] | ||||||||
ChEMBL | Displacement of fluorescently tagged SM5F from human cIAP-2 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay | B | 8.38 | pKi | 4.2 | nM | Ki | J Med Chem (2008) 51: 8158-8162 [PMID:19049347] |
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] | ||||||||
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 6.96 | pKi | 110.9 | nM | Ki | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
GtoPdb | Fluorescence polarization assay using hXIAP BIR3 domain (residues 241-356) | - | 7.59 | pKi | 26 | nM | Ki | J Med Chem (2008) 51: 8158-62 [PMID:19049347] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 6.43 | pIC50 | 369.7 | nM | IC50 | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]