MEN1611 [Ligand Id: 7743] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1684984 (CH5132799, CH-5132799, PA799, Pa-799, PA-799)
  • phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
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  • phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide in Human [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
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  • phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha in Human [ChEMBL: CHEMBL1075102] [GtoPdb: 2150] [UniProtKB: O00443]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
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  • mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
ChEMBL Inhibition of Vps34 B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1767-1772 [PMID:21316229]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
ChEMBL Inhibition of PI3KC2beta B 5.28 pIC50 5300 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1767-1772 [PMID:21316229]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075102] [GtoPdb: 2150] [UniProtKB: O00443]
ChEMBL Inhibition of PI3KC2alpha B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1767-1772 [PMID:21316229]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
GtoPdb - - 7.85 pIC50 14 nM IC50 Bioorg Med Chem Lett (2011) 21: 1767-72 [PMID:21316229]
ChEMBL Inhibition of PI3Kalpha B 7.85 pIC50 14 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1767-1772 [PMID:21316229]
ChEMBL Inhibition of PI3Kalpha (unknown origin) B 7.85 pIC50 14 nM IC50 MedChemComm (2012) 3: 1337-1355
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb - - 6.92 pIC50 120 nM IC50 Bioorg Med Chem Lett (2011) 21: 1767-72 [PMID:21316229]
ChEMBL Inhibition of PI3Kbeta B 6.92 pIC50 120 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1767-1772 [PMID:21316229]
ChEMBL Inhibition of PI3Kbeta (unknown origin) B 6.92 pIC50 120 nM IC50 MedChemComm (2012) 3: 1337-1355
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
GtoPdb - - 6.3 pIC50 500 nM IC50 Bioorg Med Chem Lett (2011) 21: 1767-72 [PMID:21316229]
ChEMBL Inhibition of PI3Kdelta B 6.3 pIC50 500 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1767-1772 [PMID:21316229]
ChEMBL Inhibition of PI3Kdelta (unknown origin) B 6.3 pIC50 500 nM IC50 MedChemComm (2012) 3: 1337-1355
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
GtoPdb - - 7.44 pIC50 36 nM IC50 Bioorg Med Chem Lett (2011) 21: 1767-72 [PMID:21316229]
ChEMBL Inhibition of PI3Kgamma B 7.44 pIC50 36 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1767-1772 [PMID:21316229]
ChEMBL Inhibition of PI3Kgamma (unknown origin) B 7.44 pIC50 36 nM IC50 MedChemComm (2012) 3: 1337-1355
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
ChEMBL Inhibition of mTOR B 5.8 pIC50 1600 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 1767-1772 [PMID:21316229]
GtoPdb - - 5.8 pIC50 1600 nM IC50 Bioorg Med Chem Lett (2011) 21: 1767-72 [PMID:21316229]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]