compound (R)-10h [PMID: 22490048] [Ligand Id: 7754] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2059513 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705] | ||||||||
| ChEMBL | Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-stimulated arachidonic acid release after 45 mins by liquid scintillation counting | F | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2012) 55: 4336-4351 [PMID:22490048] |
| GtoPdb | - | - | 8.8 | pIC50 | 1.58 | nM | IC50 | J Med Chem (2012) 55: 4336-51 [PMID:22490048] |
| ChEMBL | Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (2012) 55: 4336-4351 [PMID:22490048] |
| MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639] | ||||||||
| ChEMBL | Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting | B | 8.62 | pIC50 | 2.4 | nM | IC50 | J Med Chem (2012) 55: 4336-4351 [PMID:22490048] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
