fostamatinib [Ligand Id: 7796] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2103830 (Fostamatinib, R788 FREE ACID, R-935788, R-935788 FREE ACID, R-788 FREE ACID, R-788, R935788 FREE ACID)
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG channel B 6 pIC50 >1000 nM IC50 J. Med. Chem. (2013) 56: 1677-1692 [PMID:23350847]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Inhibition of SYK in human whole blood B 4.92 pIC50 12000 nM IC50 J. Med. Chem. (2013) 56: 1677-1692 [PMID:23350847]
ChEMBL Inhibition of SYK in human Ramos cells B 6.57 pIC50 267 nM IC50 J. Med. Chem. (2013) 56: 1677-1692 [PMID:23350847]
ChEMBL Inhibition of human recombinant truncated SYK (360 to 365 amino acid residues) using N-terminally biotinylated EPEGDYEEVLE peptide as substrate assessed as inhibition of [33P]-ATP incorporation incubated for 10 mins prior to substrate addition measured after 15 mins by scintillation counting B 7.77 pIC50 17 nM IC50 J. Med. Chem. (2013) 56: 1677-1692 [PMID:23350847]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]