compound 1 [PMID: 25408830] [Ligand Id: 7809] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1487662
  • bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
There should be some charts here, you may need to enable JavaScript!
  • bromodomain and PHD finger containing 1/Peregrin in Human [ChEMBL: CHEMBL3132741] [GtoPdb: 2730] [UniProtKB: P55201]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
GtoPdb - - 4.1 pIC50 79430 nM IC50 ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830]
ChEMBL Binding affinity to 6His-tagged-BRD4 BD1 Y390A mutant (1 to 477 aa) (unknown origin) by TR-FRET competitive assay B 4.1 pIC50 79432.82 nM IC50 ACS Med. Chem. Lett. (2014) 5: 1190-1195 [PMID:25408830]
bromodomain and PHD finger containing 1/Peregrin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3132741] [GtoPdb: 2730] [UniProtKB: P55201]
GtoPdb - - 5 pIC50 10000 nM IC50 ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830]
ChEMBL Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assay B 5 pIC50 10000 nM IC50 ACS Med. Chem. Lett. (2014) 5: 1190-1195 [PMID:25408830]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]