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ChEMBL ligand: CHEMBL1522313 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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bromodomain and PHD finger containing 3/Bromodomain and PHD finger-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3108644] [GtoPdb: 2731] [UniProtKB: Q9ULD4] | ||||||||
ChEMBL | Binding affinity to 6H-Flag-tagged Tev-BRPF3 (579-706 aa) (unknown origin) by TR-FRET competitive assay | B | 4 | pIC50 | >100000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
bromodomain containing 1/Bromodomain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176774] [GtoPdb: 2724] [UniProtKB: O95696] | ||||||||
ChEMBL | Binding affinity to 6H-Flag-tagged Tev-BRPF2 (551-673 aa) (unknown origin) by TR-FRET competitive assay | B | 5.1 | pIC50 | 7943.28 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
ChEMBL | Binding affinity to 6His-tagged-BRD4 BD1 Y390A mutant (1 to 477 aa) (unknown origin) by TR-FRET competitive assay | B | 4.3 | pIC50 | >50118.72 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL | Binding affinity to 6-His-tagged-BRD4 (1 to 477 aa) Y97A mutant (unknown origin) by TR-FRET competitive assay | B | 5.5 | pIC50 | 3162.28 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
GtoPdb | - | - | 7.1 | pIC50 | 79.4 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
bromodomain and PHD finger containing 1/Peregrin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3132741] [GtoPdb: 2730] [UniProtKB: P55201] | ||||||||
GtoPdb | - | - | 4.3 | pIC50 | >50118 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL | Binding affinity to NanoLuc-tagged BRPF1 isoform 1 bromodomain (625-735 aa) (unknown origin) expressed in HEK293 cells co-transfected with histone H3.3-HaloTag after 18 hrs by NanoBRET assay | B | 6 | pIC50 | 1000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL | Binding affinity to NanoLuc-tagged BRPF1 isoform 1 bromodomain (625-735 aa) (unknown origin) expressed in HEK293 cells co-transfected with histone H3.3-HaloTag after 18 hrs by NanoBRET assay | B | 6.01 | pIC50 | 980 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL | Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assay | B | 7.1 | pIC50 | 79.43 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]