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ChEMBL ligand: CHEMBL1522313 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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bromodomain and PHD finger containing 3/Bromodomain and PHD finger-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3108644] [GtoPdb: 2731] [UniProtKB: Q9ULD4] | ||||||||
ChEMBL | Binding affinity to 6H-Flag-tagged Tev-BRPF3 (579-706 aa) (unknown origin) by TR-FRET competitive assay | B | 4 | pIC50 | >100000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
bromodomain containing 1/Bromodomain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176774] [GtoPdb: 2724] [UniProtKB: O95696] | ||||||||
ChEMBL | Binding affinity to 6H-Flag-tagged Tev-BRPF2 (551-673 aa) (unknown origin) by TR-FRET competitive assay | B | 5.1 | pIC50 | 7943.28 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
ChEMBL | Binding affinity to 6His-tagged-BRD4 BD1 Y390A mutant (1 to 477 aa) (unknown origin) by TR-FRET competitive assay | B | 4.3 | pIC50 | >50118.72 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL | Binding affinity to 6-His-tagged-BRD4 (1 to 477 aa) Y97A mutant (unknown origin) by TR-FRET competitive assay | B | 5.5 | pIC50 | 3162.28 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
GtoPdb | - | - | 7.1 | pIC50 | 79.4 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
bromodomain and PHD finger containing 1/Peregrin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3132741] [GtoPdb: 2730] [UniProtKB: P55201] | ||||||||
GtoPdb | - | - | 4.3 | pIC50 | >50118 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL | Binding affinity to NanoLuc-tagged BRPF1 isoform 1 bromodomain (625-735 aa) (unknown origin) expressed in HEK293 cells co-transfected with histone H3.3-HaloTag after 18 hrs by NanoBRET assay | B | 6 | pIC50 | 1000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL | Binding affinity to NanoLuc-tagged BRPF1 isoform 1 bromodomain (625-735 aa) (unknown origin) expressed in HEK293 cells co-transfected with histone H3.3-HaloTag after 18 hrs by NanoBRET assay | B | 6.01 | pIC50 | 980 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL | Binding affinity to 6H-Flag-tagged Tev-BRPF1 (622-738 aa) (unknown origin) by TR-FRET competitive assay | B | 7.1 | pIC50 | 79.43 | nM | IC50 | ACS Med Chem Lett (2014) 5: 1190-1195 [PMID:25408830] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]