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ChEMBL ligand: CHEMBL437501 (L-873724) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
ChEMBL | Inhibition of Cathepsin B | B | 5.28 | pIC50 | 5239 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
ChEMBL | Inhibition of human cathepsin B | B | 5.28 | pIC50 | 5239 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
ChEMBL | Inhibition of cathepsin B | B | 5.28 | pIC50 | 5239 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
ChEMBL | Potency against Cathepsin B in HepG2 cells by whole cell enzyme occupancy assay | B | 5.32 | pIC50 | 4807 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
ChEMBL | Inhibition of cathepsin B in human HepG2 cells | B | 5.32 | pIC50 | 4807 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
cathepsin B/Cathepsin B in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5187] [GtoPdb: 2343] [UniProtKB: P10605] | ||||||||
ChEMBL | Inhibition of mouse recombinant cathepsin B | B | 6.27 | pIC50 | 540 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
cathepsin B/Cathepsin B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2602] [GtoPdb: 2343] [UniProtKB: P00787] | ||||||||
ChEMBL | Inhibition of rat liver lysosomal cathepsin B | B | 6.03 | pIC50 | 925 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
ChEMBL | Inhibition of humanized rabbit Cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4328-4332 [PMID:17544269] |
ChEMBL | Inhibition of human cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
ChEMBL | Inhibition of human cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
ChEMBL | Inhibition of cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2008) 51: 4359-4369 [PMID:18570365] |
ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 920-923 [PMID:21232956] |
GtoPdb | - | - | 9.7 | pIC50 | 0.2 | nM | IC50 | Biol Chem (2009) 390: 941-8 [PMID:19453281] |
Cathepsin K in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3349] [UniProtKB: P43236] | ||||||||
ChEMBL | Potency against Cathepsin K in rabbit osteoclasts by bone resorption assay | F | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
ChEMBL | Inhibition of rabbit cathepsin K | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
cathepsin K/Cathepsin K in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075277] [GtoPdb: 2350] [UniProtKB: P55097] | ||||||||
ChEMBL | Inhibition of mouse recombinant cathepsin K | B | 7.37 | pIC50 | 43 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
ChEMBL | Potency against Cathepsin L in HepG2 cells by whole cell enzyme occupancy assay | B | 5.91 | pIC50 | 1221 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
ChEMBL | Inhibition of cathepsin L in human HepG2 cells | B | 5.91 | pIC50 | 1221 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
ChEMBL | Inhibition of Cathepsin L | B | 6.58 | pIC50 | 264 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
ChEMBL | Inhibition of human cathepsin L | B | 6.58 | pIC50 | 264 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
ChEMBL | Inhibition of cathepsin L | B | 6.58 | pIC50 | 264 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
cathepsin V/Cathepsin L in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2305] [GtoPdb: 2352] [UniProtKB: P07154] | ||||||||
ChEMBL | Inhibition of rat liver lysosomal cathepsin L | B | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
cathepsin L/Cathepsin L1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5291] [GtoPdb: 2351] [UniProtKB: P06797] | ||||||||
ChEMBL | Inhibition of mouse recombinant cathepsin L | B | 6.6 | pIC50 | 254 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
ChEMBL | Inhibition of Cathepsin S | B | 6.75 | pIC50 | 178 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
ChEMBL | Inhibition of human cathepsin S | B | 6.75 | pIC50 | 178 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
ChEMBL | Inhibition of cathepsin S | B | 6.75 | pIC50 | 178 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
ChEMBL | Potency against Cathepsin S in Ramos cells by whole cell enzyme occupancy assay | B | 7.02 | pIC50 | 95 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
ChEMBL | Inhibition of cathepsin S in human ramos cells | B | 7.02 | pIC50 | 95 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
cathepsin S/Cathepsin S in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4098] [GtoPdb: 2353] [UniProtKB: O70370] | ||||||||
ChEMBL | Inhibition of mouse recombinant cathepsin S | B | 6.6 | pIC50 | 254 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
cathepsin S/Cathepsin S in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075217] [GtoPdb: 2353] [UniProtKB: Q02765] | ||||||||
ChEMBL | Inhibition of rat spleen cathepsin S | B | 5.61 | pIC50 | 2441 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]