L873724 [Ligand Id: 7860] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL437501 (L-873724) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of Cathepsin B | B | 5.28 | pIC50 | 5239 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
| ChEMBL | Inhibition of human cathepsin B | B | 5.28 | pIC50 | 5239 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of cathepsin B | B | 5.28 | pIC50 | 5239 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Potency against Cathepsin B in HepG2 cells by whole cell enzyme occupancy assay | B | 5.32 | pIC50 | 4807 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
| ChEMBL | Inhibition of cathepsin B in human HepG2 cells | B | 5.32 | pIC50 | 4807 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin B/Cathepsin B in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5187] [GtoPdb: 2343] [UniProtKB: P10605] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin B | B | 6.27 | pIC50 | 540 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin B/Cathepsin B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2602] [GtoPdb: 2343] [UniProtKB: P00787] | ||||||||
| ChEMBL | Inhibition of rat liver lysosomal cathepsin B | B | 6.03 | pIC50 | 925 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
| ChEMBL | Inhibition of humanized rabbit Cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
| ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4328-4332 [PMID:17544269] |
| ChEMBL | Inhibition of human cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Inhibition of human cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Inhibition of cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2008) 51: 4359-4369 [PMID:18570365] |
| ChEMBL | Inhibition of humanized rabbit cathepsin K | B | 9.7 | pIC50 | 0.2 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 920-923 [PMID:21232956] |
| GtoPdb | - | - | 9.7 | pIC50 | 0.2 | nM | IC50 | Biol Chem (2009) 390: 941-8 [PMID:19453281] |
| Cathepsin K in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3349] [UniProtKB: P43236] | ||||||||
| ChEMBL | Potency against Cathepsin K in rabbit osteoclasts by bone resorption assay | F | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
| ChEMBL | Inhibition of rabbit cathepsin K | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin K/Cathepsin K in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075277] [GtoPdb: 2350] [UniProtKB: P55097] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin K | B | 7.37 | pIC50 | 43 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
| ChEMBL | Potency against Cathepsin L in HepG2 cells by whole cell enzyme occupancy assay | B | 5.91 | pIC50 | 1221 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
| ChEMBL | Inhibition of cathepsin L in human HepG2 cells | B | 5.91 | pIC50 | 1221 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Inhibition of Cathepsin L | B | 6.58 | pIC50 | 264 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
| ChEMBL | Inhibition of human cathepsin L | B | 6.58 | pIC50 | 264 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of cathepsin L | B | 6.58 | pIC50 | 264 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin V/Cathepsin L in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2305] [GtoPdb: 2352] [UniProtKB: P07154] | ||||||||
| ChEMBL | Inhibition of rat liver lysosomal cathepsin L | B | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin L/Cathepsin L1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5291] [GtoPdb: 2351] [UniProtKB: P06797] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin L | B | 6.6 | pIC50 | 254 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
| ChEMBL | Inhibition of Cathepsin S | B | 6.75 | pIC50 | 178 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
| ChEMBL | Inhibition of human cathepsin S | B | 6.75 | pIC50 | 178 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of cathepsin S | B | 6.75 | pIC50 | 178 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| ChEMBL | Potency against Cathepsin S in Ramos cells by whole cell enzyme occupancy assay | B | 7.02 | pIC50 | 95 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1985-1989 [PMID:16413777] |
| ChEMBL | Inhibition of cathepsin S in human ramos cells | B | 7.02 | pIC50 | 95 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 923-928 [PMID:18226527] |
| cathepsin S/Cathepsin S in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4098] [GtoPdb: 2353] [UniProtKB: O70370] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin S | B | 6.6 | pIC50 | 254 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin S/Cathepsin S in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075217] [GtoPdb: 2353] [UniProtKB: Q02765] | ||||||||
| ChEMBL | Inhibition of rat spleen cathepsin S | B | 5.61 | pIC50 | 2441 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
